Effect of Pravastatin on Experimental Diabetic Wound Healing

Tight glycaemic control is a key factor in wound healing enhancement strategies in an experimental diabetes mellitus model

“…TGFb has been shown to, in part, regulate angiogenesis, chemotaxis, proliferation, synthesis and degradation of extracellular matrix necessary for tissue repair. The TGFb results in this study are similar to the findings previously published [7,9,10] Fig. 12 Transforming growth factor b1 demonstrate clearly the significant impact the diabetic state has on acute wound healing in the non-glycaemic controlled animal.…”

“…The diabetic state was successfully induced using an intraperitoneal injection of streptozotocin [8][9][10] in 16 male Sprague-Dawley rats. 6 animals served as controls and were injected with normal saline.…”

“…The aim of this study was to establish a glucosecontrolled diabetic wound healing model and to investigate the impact of tight glycaemic control. The wound healing model, used in this study, of a central incisional wound with the placement of subcutaneous poly vinyl alcohol sponges, is a well-established model in the literature [9,10]. A normoglycaemic diabetes mellitus model using streptocozin Sprague-Dawley rats has been described in the literature with regard to bowel anastomosis and femur fracture healing [16,17].…”

“…At day -11 the Sprague-Dawley rats were rendered diabetic by a single intra-peritoneal injection of streptozotocin (70 mg/kg diluted in 0.2 Ml of saline) [8][9][10]. Nondiabetic animals (control group C) received an identical amount of saline only by the same route.…”

Azelnidipine, a New Calcium Channel Blocker, Promotes Skin Wound Healing in Diabetic Rats

“…There are growing data which suggest that restoring NO bioavailability may ameliorate delayed diabetic wound healing [27]. In previous studies, it was shown that different therapeutic regimens and interventions such as L-arginine supplementation, propranolol or pravastatin administration, and gene therapy of eNOS could enhance wound healing rate by increasing NO bioavailability in wound tissue [27][28][29][30]. We have also shown in this study that wound healing enhancement by AZL administration was paralleled by restoring NO-deficient state in diabetic rats.…”