Effect of Preeclampsia on Blood Pressure in Newborn Very Low Birth Weight Infants

Swarup, Jyothi; Balkundi, Dhruv R; Brozanski, Beverly; Roberts, James M.; Yanowitz, Toby

doi:10.1080/10641950500281209

Cited by 12 publications

(7 citation statements)

References 30 publications

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“…However we excluded infants born to mothers with preeclampsia a priori because our own data confirm that they have higher BP than infants born to mothers without preeclampsia. 7 When the analysis was repeated with these infants included (data not presented), the results were unchanged, with the sole exception that the association of FVI with lower BP in the oldest GA stratum was even stronger than reported.…”

Section: Significancementioning

confidence: 85%

“…In addition, infants born to mothers with pre-eclampsia were excluded because we have shown that these infants may have elevated BP in the first week of life. 7 BP in the immediate newborn period is tightly correlated with gestational age (GA). 8 Thus, infants were placed into one of three GA stratum: 23 to 26, 27 to 29, and Z30 weeks based on the best estimate of GA. Obstetrical dating was used if an ultrasound was obtained prior to 18 weeks gestation or if the date of the last menstrual period was known.…”

Section: Materials and Methods Study Designmentioning

confidence: 99%

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Low Blood Pressure among Very-low-birth-weight Infants with Fetal Vessel Inflammation

et al. 2004

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Section: Significancementioning

confidence: 85%

Section: Materials and Methods Study Designmentioning

confidence: 99%

Low Blood Pressure among Very-low-birth-weight Infants with Fetal Vessel Inflammation

et al. 2004

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“…The majority of studies (Palti and Rothschild, 1989; Seidman et al, 1991; Tenhola et al, 2003, 2006; Vatten et al, 2003; Swarup et al, 2005; Hiller et al, 2007; Oglaend et al, 2009; Kvehaugen et al, 2010; Lazdam et al, 2010; Palmsten et al, 2010; Lawlor et al, 2012), but not all (Ounsted et al, 1983; Jayet et al, 2010; Belfort et al, 2012; Lawlor et al, 2012) report that children and adolescents who were exposed to preeclampsia or hypertension in pregnancy exhibit higher systolic and diastolic blood pressure compared with non-exposed children or adolescents. These studies were reviewed in a recent meta-analysis (Davis et al, 2012a), which included individuals aged 4–30 years, born at term from preeclamptic pregnancies.…”

Section: Developmental Origins Of Adult Disease After Preeclampsiamentioning

confidence: 99%

Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming

et al. 2014

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Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is also characterized by impaired blood flow through the utero-placental circulation and relative placental ischemia, which in turn, may generate feto-placental endothelial dysfunction. Endothelial dysfunction in offspring born from preeclamptic pregnancies has been associated with an increased risk of cardiovascular disease, including hypertension, later in life. Interestingly, diminished endothelial function, manifested by low angiogenic capacity, leads to hypertension in animal studies. Recently, we have shown that the adenosine receptor A2A/nitric oxide/vascular endothelial growth factor axis is reduced in human umbilical vein endothelial cells derived from preeclamptic pregnancies, an effect correlated with gestational age at onset of preeclampsia. We and others suggested that impaired vascular function might be associated with high cardiovascular risk in offspring exposed to pregnancy diseases. However, we are not aware of any studies that examine impaired adenosine-mediated angiogenesis as a possible link to hypertension in offspring born from preeclamptic pregnancies. In this review, we present evidence supporting the hypothesis that reduced adenosine-mediated angiogenesis during preeclamptic pregnancies might be associated with development of hypertension in the offspring.

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“…Maternal morbidity, smoking and medication with indomethacin, MgSo 4 , antihypertensive drugs, e.g. methyldopa, dihydralazine, labetolol and nifedipine were registered, as was administration of antenatal betamethasone for fetal lung maturation [26][27][28][29][30] . Blood pressure was always monitored by an indwelling arterial catheter (umbilical, radial, ulnar or tibial artery) connected to a continuous monitoring system.…”

Section: Methodsmentioning

confidence: 99%

Inverse Relationship between Birth Weight and Blood Pressure in Growth-Retarded but Not in Appropriate for Gestational Age Infants during the First Week of Life

et al. 2009

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Background: Various studies have shown an association between low birth weight and the prevalence of elevated blood pressure later in life. However, a relationship between birth weight and blood pressure in the neonatal period has not been investigated yet. Objective: To study the relationship between birth weight and blood pressure during the first week of life. Methods: Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MBP) were measured every 8 h during days 1, 2, 3, 4 and 7 in 44 small for gestational age (SGA) infants and compared with those of infants born with a birth weight appropriate for gestational age (AGA). The infants were matched for gestational age and gender. Results: Meanbirth weight (range) in the SGA group was 778 (460–1,400) g versus 1,524 (960–2,730) g in the AGA group, and mean (range) gestational age of both groups was 30.5 (27.3–35.5) weeks. In the first week of life, SGA and AGA infants had similar SBP, DBP and MBP. Also, after adjustment for confounders (maternal medication, smoking), SBP, DBP and MBP rose equally in SGA and AGA infants during the first week of life. AGA infants showed a positive correlation between birth weight and blood pressure, but SGA infants showed an inverse correlation. Conclusions: Although differences in blood pressure were found between SGA and AGA infants in the first week of life, the inverse relationship between birth weight and blood pressure in SGA infants warrants follow-up studies to investigate a possible link with late cardiovascular disease.

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Effect of Preeclampsia on Blood Pressure in Newborn Very Low Birth Weight Infants

Abstract: Preeclampsia is associated with higher blood pressure in very low birth weight neonates who are >or= 29 weeks gestation. The long-term significance of this finding is not known.

Cited by 12 publications

References 30 publications

Low Blood Pressure among Very-low-birth-weight Infants with Fetal Vessel Inflammation

Low Blood Pressure among Very-low-birth-weight Infants with Fetal Vessel Inflammation

Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming

Inverse Relationship between Birth Weight and Blood Pressure in Growth-Retarded but Not in Appropriate for Gestational Age Infants during the First Week of Life

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