Effect of preemptive analgesia with intravenous oxycodone in the patients undergoing laparoscopic resection of ovarian tumor

Wang, Na; Wang, Yuantao; Pang, Lei

doi:10.12669/pjms.312.6686

Cited by 11 publications

(13 citation statements)

References 12 publications

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“…24 A clinical study suggested that preemptive administration of oxycodone 0.1 mg/kg could effectively depress the stress response and was conducive to maintain intraoperative hemodynamic stability. 11 Moreover, Park et al 25 also revealed that the hemodynamics changes could be attenuated by pretreatment of 0.1 mg/kg intravenous oxycodone during the induction period. Therefore, we selected the dosage of oxycodone 0.1 mg/kg for preemptive analgesia, which is also the usual dosage of preemptive administration in our center.…”

Section: Discussionmentioning

confidence: 99%

“…For patients undergoing noncardiac surgery, the equivalent dose of sufentanil and oxycodone is 1:750 to 1000 . A clinical study suggested that preemptive administration of oxycodone 0.1 mg/kg could effectively depress the stress response and was conducive to maintain intraoperative hemodynamic stability . Moreover, Park et al also revealed that the hemodynamics changes could be attenuated by pretreatment of 0.1 mg/kg intravenous oxycodone during the induction period.…”

Section: Discussionmentioning

confidence: 99%

“…The electrocardiogram, heart rate (HR), pulse oximeter, bispectral index (BIS), and nasopharyngeal temperature were routinely monitored. Thirty minutes before anesthesia, patients in group Oxy received oxycodone 0.1 mg/kg, patients in group NS received an equivalent volume of normal saline, and group Suf were given sufentanil 0.1 μg/kg (clinical dosage). After local anesthesia, the arterial line and central line placement were implemented for continuously monitoring of arterial blood pressure and central venous pressure during the procedure.…”

Section: Methodsmentioning

confidence: 99%

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Preemptive Anti–Stress Response Effects of Oxycodone Versus Sufentanil for Patients Undergoing Cardiac Valve Replacement—A Randomized Controlled Trial

Zhang

Gan

et al. 2019

Clinical Pharm in Drug Dev

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Patients undergoing cardiac valve replacement may experience cardiovascular adverse events during the preoperative period before anesthesia. The study was to compare the preemptive anti–stress response effects of oxycodone versus sufentanil for patients undergoing cardiac valve replacement. Ninety‐four patients were enrolled and assigned to group Oxy, group Suf and group NS. Patients in group Oxy were administrated with oxycodone 0.1 mg/kg, group Suf received sufentanil 0.1 μg/kg and group NS were given equivalent volume of normal saline. The primary outcomes included serum levels of cortisol, norepinephrine, and adrenaline. The secondary outcomes involved bispectral index value and the observer's assessment of awareness/sedation grade, levels of mean arterial pressure, heart rate, and the adverse reactions. Compared to group NS, the serum levels of cortisol at T1 to T5 (P < .05), and levels of norepinephrine and adrenaline at T3 to T5 (P < .05) in group Oxy and Suf were lower. The bispectral index value and observer's assessment of awareness/sedation grade T1 to T2 (P < .05) in group Suf were lower than those in group Oxy and NS. Compared with group NS, the levels of mean arterial pressure and heart rate in group Oxy and Suf at T3 to T5 (P < .05) were lower. The incidence of coughing was significantly higher in group Suf (23.3%), but not in group NS (6.7%), than that in group Oxy (3.3%). The preemptive analgesia of oxycodone may be used to inhibit the stress response, without leading to excessive sedation and respiratory depression, which may also help to stabilize hemodynamics during preoperative period.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Preemptive Anti–Stress Response Effects of Oxycodone Versus Sufentanil for Patients Undergoing Cardiac Valve Replacement—A Randomized Controlled Trial

Zhang

Gan

et al. 2019

Clinical Pharm in Drug Dev

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“… 1 - 5 Compared with morphine, hydromorphone may be the ideal intravenous opioid for preemptive analgesia because it is approximately 7 times more potent and has a faster onset, due to its increased lipophilia. 6 , 7 According to previous studies, 2 , 4 , 5 preemptive opioid decrease hemodynamic changes, pain intensity and morphine consumption without increased side effects. To the best of our knowledge, no comprehensive data have been found with regard to efficacy of preoperative hydromorphone, so we design this prospective, double-blinded, randomized and parallel clinical research to evaluate it.…”

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confidence: 94%

Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy

Wang

Zhou

et al. 2018

SMJ

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Objectives:To determine the efficacy of preemptive hydromorphone for laparoscopic radical gastrectomy.Methods:The present prospective and double-blinded study was performed in the The First Hospital, Jilin University, Changchun, China, between July 2017 and April 2018. Fifty patients scheduled for laparoscopic radical, gastrectomy were equally randomized into 2 groups, which were administrated different drugs 10 minutes before surgery. Group P (the preemptive hydromorphone group) was administrated 2 mg hydromorphone (2 mL), and Group C (the control group) was administrated 2 mL normal saline intravenously. A standardized general anesthesia were conducted. Blood pressure and heart rate, postoperative morphine consumption, pain intensity, sedation status, and side effects were recorded.Results:Group C had larger intraoperative hemodynamic changes, higher postoperative visual analogue scale score, more morphine consumption and lower overall satisfaction degree than Group P. No difference was found between the 2 groups in sedation status and adverse effects.Conclusion:Preoperative 2 mg hydromorphone could reduce intraoperative changes of blood pressure and heart rate, postoperative pain intensity, and morphine consumption without an increase of adverse effects.

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“…However, it also increases the incidence of postoperative nausea and vomiting. [10] Oxycodone is a semi-synthetic opioid analgesic, which can effectively relieve visceral pain by stimulating µ and κ receptors, especially κ receptors, and it has fewer adverse reactions than other opioid drugs. [11,12] Studies have shown that both µ and κ receptors exist in the gastrointestinal tract, and their functions include controlling visceral pain.…”

Section: Introductionmentioning

confidence: 99%

The effect of oxycodone on postoperative pain and inflammatory cytokine release in elderly patients undergoing laparoscopic gastrectomy

Lao

Song

Jiang

et al. 2020

Preprint

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Background To evaluate the effect of oxycodone on postoperative pain and inflammation in elderly patients undergoing laparoscopic gastrectomy. Methods Sixty patients who were of both sexes, American Society of Anesthesiologists Physical Status (ASA-PS) Class I or II, over 65 years of age and undergoing an elective laparoscopic radical gastrectomy were randomly divided into two groups: an oxycodone group (Group O) and a sufentanil group (Group S). The postoperative analgesia regimen was as follows: 40 mg of parecoxib sodium and 0.1 mg/kg of oxycodone was intravenously injected into Group O before the abdomen closure, while 40 mg of parecoxib sodium and 0.1 μg/kg of sufentanil was injected intravenously into Group S. Both groups were infiltrated with 20 ml of 1% ropivacaine at the end of the operation. The concentrations of IL-6 and IL-10 were measured immediately after the operation and one hour, six hours and twenty-four hours after the operation (T1-4). The numerical rating scale (NRS), the Ramsay sedation score, analgesic-related adverse events, postoperative pulmonary inflammation events and the postoperative stay were recorded. Results Compared with Group S, the serum IL-6 concentrations of Group O decreased at T3 and T4, while the serum IL-10 concentrations increased (P < 0.05). In Group O, the serum IL-6 concentrations at T3 and T4 were lower than those at T1 (P < 0.05). The incidence of postoperative nausea and vomiting（PONV）and pulmonary inflammation in Group O was lower than that in Group S (P < 0.05). At each time point, the NRS of visceral pain in Group O was lower than that in Group S. At six and twenty-four hours after extubation, the NRS of incision pain in Group O was lower than that in Group S (P < 0.05). Conclusion Oxycodone can regulate the level of inflammatory cytokines and reduce postoperative inflammatory response.

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Effect of preemptive analgesia with intravenous oxycodone in the patients undergoing laparoscopic resection of ovarian tumor

Cited by 11 publications

References 12 publications

Preemptive Anti–Stress Response Effects of Oxycodone Versus Sufentanil for Patients Undergoing Cardiac Valve Replacement—A Randomized Controlled Trial

Preemptive Anti–Stress Response Effects of Oxycodone Versus Sufentanil for Patients Undergoing Cardiac Valve Replacement—A Randomized Controlled Trial

Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy

The effect of oxycodone on postoperative pain and inflammatory cytokine release in elderly patients undergoing laparoscopic gastrectomy

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