Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy

Abstract

Objectives:To determine the efficacy of preemptive hydromorphone for laparoscopic radical gastrectomy.Methods:The present prospective and double-blinded study was performed in the The First Hospital, Jilin University, Changchun, China, between July 2017 and April 2018. Fifty patients scheduled for laparoscopic radical, gastrectomy were equally randomized into 2 groups, which were administrated different drugs 10 minutes before surgery. Group P (the preemptive hydromorphone group) was administrated 2 mg hydromorphone (2 mL), and Group C (the control group) was administrated 2 mL normal saline intravenously. A standardized general anesthesia were conducted. Blood pressure and heart rate, postoperative morphine consumption, pain intensity, sedation status, and side effects were recorded.Results:Group C had larger intraoperative hemodynamic changes, higher postoperative visual analogue scale score, more morphine consumption and lower overall satisfaction degree than Group P. No difference was found between the 2 groups in sedation status and adverse effects.Conclusion:Preoperative 2 mg hydromorphone could reduce intraoperative changes of blood pressure and heart rate, postoperative pain intensity, and morphine consumption without an increase of adverse effects.

Hydromorphone Protects against CO2 Pneumoperitoneum‐Induced Lung Injury via Heme Oxygenase‐1‐Regulated Mitochondrial Dynamics

“…Additionally, when used in postoperative pain management, hydromorphone had better anti-inflammatory effects than other sufentanil in patients who received thoracic surgery, as shown by lower levels of C-reactive protein (CRP) in the plasma and fewer pulmonary complications [ 42 ]. To investigate the role of hydromorphone in clinical patients receiving gynecological laparoscopic surgery, we used a dosage of hydromorphone equianalgesic to the dosage of morphine used in other studies [ 43 ]. CC-16 is regarded as a lung secretory protein that protects against oxidative stress and inflammation.…”