Effect of premedication and other factors on the occurrence of acute transfusion reactions in dogs

Bruce, Joshua A.; Kriese-Anderson, L. A.; Bruce, Ashley M.; Pittman, Jennifer R.

doi:10.1111/vec.12327

Cited by 47 publications

(99 citation statements)

References 43 publications

(249 reference statements)

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“…A study in dogs reported a transfusion reaction rate of 15%, with reactions being more common with pRBC transfusions compared to other blood products (Bruce et al . ). In people, transfusion reactions are well defined and rates of between 0.2 and 3.8% have been reported, with variation between studies and blood products administered (Kato et al .…”

Section: Discussionmentioning

confidence: 97%

Prospective evaluation of the utility of cross‐matching prior to first transfusion in cats: 101 cases

Humm

Chan

2020

J of Small Animal Practice

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Objectives: To: (1) assess the frequency of crossmatch incompatibility in naïve feline blood transfusion recipients using two crossmatching methods, (2) measure the effect of crossmatch incompatibility on change in packed cell volume following transfusion, (3) assess the frequency of acute transfusion reactions and errors in blood transfusions in cats and (4) assess the impact of crossmatch incompatibility on the likelihood of transfusion reactions. Materials and MethOds:Cats being administered a first AB-matched transfusion in a veterinary teaching hospital were prospectively recruited for this observational study. A slide agglutination method and a commercial test were both used for major and minor crossmatching. We measured increase in packed cell volume at 12 hours after transfusion relative to the mass of red blood cells given per recipient bodyweight and recorded transfusion reactions.results: A total of 101 cats was included. Crossmatch incompatibility was common using the slide agglutination method (27% and 10% major and minor incompatibility, respectively), but less common with the commercial test (major and minor incompatibility both 4%). Crossmatch incompatibility with any method was not associated with less effective transfusion in terms of change in packed cell volume. Transfusion reactions occurred in 20 cats, most commonly febrile non-haemolytic transfusion reactions (n = 9) and haemolytic transfusion reactions (n = 7). The commercial test appeared to be most specific for predicting haemolytic transfusion reactions.clinical significance: Transfusion reactions were fairly common but not associated with increased mortality. Use of crossmatch-compatible blood did not lead to a greater increase in PCV at 12 hours.The commercial test may predict a haemolytic transfusion reaction.

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Section: Discussionmentioning

confidence: 97%

Prospective evaluation of the utility of cross‐matching prior to first transfusion in cats: 101 cases

Humm

Chan

2020

J of Small Animal Practice

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“…None of the 7 dogs with acute reactions in that study 20 had a prior transfusion, so crossmatching was not performed before administration of RBCs. In another study, 21 all dogs that had a hemolytic transfusion reaction (4/558 [0.7%]) were transfusion-naïve dogs that did not have a crossmatch evaluation before the transfusion was administered. Because our study was retrospective and some medical records were incomplete, the incidence of transfusion reactions in the present study could not be properly evaluated.…”

Section: Discussionmentioning

confidence: 99%

Incidence of incompatible crossmatch results in dogs admitted to a veterinary teaching hospital with no history of prior red blood cell transfusion

Odunayo¹,

Garraway²,

Rohrbach³

et al. 2017

javma

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OBJECTIVE To determine the incidence of incompatible crossmatch results in dogs without a history of prior RBC transfusion and to evaluate changes in Hct following RBC administration for transfusion-naïve dogs that did and did not have crossmatching performed. DESIGN Retrospective study. ANIMALS 169 client-owned dogs. PROCEDURES Information obtained from the medical records included signalment, pretransfusion Hct or PCV, and crossmatching results where applicable. Dogs that underwent major crossmatching (n = 149) as part of pretransfusion screening were each crossmatched with 3 potential donors. Donor blood was obtained from a commercial source and tested negative for dog erythrocyte antigens (DEAs) 1.1, 1.2, and 7 but positive for DEA 4. Mean change in Hct after transfusion was compared between crossmatch-tested dogs (57/91 that subsequently underwent RBC transfusion) and 20 other dogs that underwent RBC transfusion without prior crossmatching by statistical methods. RESULTS 25 of 149 (17%) dogs evaluated by crossmatching were incompatible with 1 or 2 of the 3 potential donors. All 149 dogs were compatible with ≥ 1 potential donor. Mean ± SD change in Hct after transfusion was significantly higher in dogs that had crossmatching performed (12.5 ± 8.6%) than in dogs that did not undergo crossmatching (9.0 ± 4.3%). CONCLUSIONS AND CLINICAL RELEVANCE Results indicated immunologic incompatibility can exist between first-time transfusion recipients and potential blood donor dogs. The clinical importance of these findings could not be evaluated, but considering the potential for immediate or delayed hemolytic transfusion reactions or shortened RBC life span, the authors suggest veterinarians consider crossmatching all dogs prior to transfusion when possible.

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“…11 Additionally, a recent study in dogs that included 412 FFP transfu-sions reported an ATR rate of 8%, which was lower than packed RBCs (pRBCs) (17%) and whole blood (15%). 18 Red cell rates of ATR in cats are reported to be between 2.2% and 8.7% and, more recently, up to 17% and 29%, 13,[19][20][21][22] whereas the rate of FFP ATR remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that coagulopathy would be the most common indication for FFP transfusion, and the rate of ATR would be comparable to studies in dogs. 11,12,18 It was also hypothesized that FFP administration would result in improvements in blood pressure, total plasma protein, and prothrombin time (PT)/aPTT. Finally, we hypothesized that the transfusion dose administered (in mL/kg) would be lower in cats as compared to people and dogs.…”

Section: Introductionmentioning

confidence: 99%

Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016

Lane

Sinnott‐Stutzman

2020

J Vet Emergen Crit Care

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Objectives To document indications for fresh frozen plasma (FFP) use in cats, doses administered, and frequency of adverse transfusion reactions (ATR). Design Retrospective observational study from January 2009 to November 2016. Setting Large urban referral and emergency facility. Animals One hundred twenty‐one client‐owned cats that received FFP. Interventions None. Measurements and Main Results Signalment, indication(s), dose, pre‐ and posttransfusion total plasma protein, prothrombin time, activated partial thromboplastin time, as well as possible ATR, primary disease process, and outcome were recorded. Doppler blood pressure was increased posttransfusion (mean pre 99.5 ± 30.8 mm Hg; post 108.5 ± 32.5 mm Hg, P = .027). Cats were significantly less likely to be coagulopathic posttransfusion (P < 0.001). Most common indications were suspected coagulopathy (n = 105, 83%), hemorrhage (n = 45, 35%), and hypotension (n = 32, 25%). Median dose was 6 mL/kg (interquartile range = 3 mL/kg) and was negatively correlated with body weight (r = –.598, P < 0.001). Possible ATR occurred in 17 of 108 (16%, 95% confidence interval [CI], 10–24%) of transfusions. Increased body temperature was most common in 11 of 108 (10%, 95% CI, 5–18%), followed by tachypnea/dyspnea in 8 of 108 (7%, 95% CI, 3–13%). Common primary disease processes included liver disease (n = 41, 34%), neoplasia (n = 19, 16%), and sepsis (n = 15, 12%). Overall mortality was 54%. Improvement of clotting times was associated with increased odds of survival (odds ratio = 2.4; 95% CI, 1.1–5.3; P = 0.023). Conclusions Clinician justifications for FFP transfusions are comparable to that reported in dogs; however, the mL/kg dose is lower. Coagulopathy and blood pressure significantly improve posttransfusion. Possible ATR were as frequent as that reported with feline packed RBCs transfusions and classified as mild.

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Effect of premedication and other factors on the occurrence of acute transfusion reactions in dogs

Cited by 47 publications

References 43 publications

Prospective evaluation of the utility of cross‐matching prior to first transfusion in cats: 101 cases

Prospective evaluation of the utility of cross‐matching prior to first transfusion in cats: 101 cases

Incidence of incompatible crossmatch results in dogs admitted to a veterinary teaching hospital with no history of prior red blood cell transfusion

Retrospective evaluation of fresh frozen plasma use in 121 cats: 2009–2016

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