Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis

Premchandran, Divya; Madhyastha, Sampath; Saralaya, Vasudha; Joy, Teresa; Sahu, Sudhanshu Sekhar; Rachana, Kuruvanthe S.

doi:10.9790/3013-0311035-40

Cited by 2 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inappropriately, retinoids are extremely teratogenic in humans, equal in the therapeutic dosage Even though the mechanism of action of Isotretinoin leading to the droplet in fur of the treated group is static unclear but it is identified that like other retinoids, isotretinoin works by DNA transcription shifting. [9], this effect declines the dimension and production of sebaceous off into the sebaceous glands, creates the cells that are sloughed off into the sebaceous glands fewer sticky, and hence less capable to form comedones. A loss in the weight of the maternal after gestation related to the weight before gestation and control group could be an indicator of drop in the appetite and ill health which essential have been produced by the release of free radicals [10], also related Science, 2017, Vol.…”

Section: Discussionmentioning

confidence: 99%

Histological study of the Isotretinoin drug effect on the intrauterine prenatal development in the pregnant mice

2017

ijs

View full text Add to dashboard Cite

The isotretinoin drug is 13-cis-retinoic acid, is the treatment of severe acne and some skin cancers and used for dermatological conditions, this study was designed to detect the toxic role of the isotretinoin on the intrauterine development after implantation in albino mice during pregnancy. There are very little studies which indicating the side-effect of this drug on intra-uterine growth, so in the present research we tried to study the toxic effect of isotretinoin on the endometrial changes of uterus during the 2 nd. and 3 rd. trimester of gestation in pregnant mice after treatment with single chronic dose of the Isotretinoin drug (20 mg/B.wt) from first day of gestation until 21 days the last day of gestation. The present study examination of the uterus during the particular gestational days were perceived some fault in the endometrium tissue of the uterus since the hyperplasia of the lining epithelium of the uterus and thickening of the endometrium because of propagation of the endometrial glands and stroma and widening of the endometrial cavity in both control and treated groups of pregnant mice after the 7 day of gestation, we found some morphological changes appear in the pregnant mothers like, more thickness skin and change color of the body fur from white to yellow-whitish color, and less physical active and drop in appetite. The morphological changes in the pregnant mice after treated with (20mg / kg B.wt), isotretinoin dose, appear a significant decrease (p≤0.05) in the body weight. The histological results show a decreased in the numbers of the papillary projects of the endometrial tissue and change with few in numbers of the endometrial glands and loss stroma with thickness of the lining epithelium and this may because the resorption of the embryos inside the uterus compared to the control group. The present study clearly determine that the effect of isotretinoin on the histopathology of the uterus through pregnancy cause toxic on the embryos and result in resorption and damage the implanted embryos at altered particular gestational days in mice, as a result isotretinoin should be taking with attention and avoided at first post-implantation phase of gestation.

show abstract

Section: Discussionmentioning

confidence: 99%

Histological study of the Isotretinoin drug effect on the intrauterine prenatal development in the pregnant mice

2017

ijs

View full text Add to dashboard Cite

show abstract

“…Taking isotretinoin 30 d before and during pregnancy has been reported to cause fetal or neonatal problems (above 16 w of gestation), such as fetal death in the uterus, congenital birth defects, and neural tube defects. Congenital anomalies include abnormalities of the skin, abdominal wall, cardiovascular, digestive, nervous, musculoskeletal, respiratory, and urogenital system, as well as multiple chromosomal anomalies/ syndromes and other congenital malformations [41,42].…”

Section: Side Effects and Monitoringmentioning

confidence: 99%

Isotretinoin for Treating Acne Vulgaris

Sitohang

2021

Int J App Pharm

View full text Add to dashboard Cite

Acne vulgaris (AV) occurs in more than 80% of dermatological cases in adolescents and young adults and affects the quality of life. Oral isotretinoin, a metabolite product of vitamin A, is well-known to be the most effective treatment for severe nodulocystic AV and moderate AV that does not respond to other therapeutic modalities. Thus, this literature review was conducted to explain the mechanism of action, effectiveness, contraindications, side effects, and safety of oral isotretinoin in AV, which provided essential information for dermatologists. Furthermore, isotretinoin is the only treatment modality that has implications for the entire pathogenesis of acne. It contributes to decreasing corneocytes’ adhesion, supporting cellular proliferation and follicular renewal, induction of cell apoptosis, and immune regulation. The effectiveness of AV therapy with isotretinoin has expanded as it is also indicated for moderate to severe AV that does not respond well to topical combination therapy or systemic antibiotics. However, isotretinoin is included in Category X drugs and may induce many side effects from mucocutaneous effects to teratogenicity. From this extensive literature review, it can be concluded that isotretinoin is one of the treatment modalities for acne with good effectivity due to its mechanism of actions that affect the entire acne pathogenesis. Considering the various side effects of isotretinoin, its use requires adequate clinical assessment and monitoring by a dermatologist.

show abstract

Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis

Abstract: Isotretinoin is a known teratogen affecting the neuronal differentiation in developing brain

Cited by 2 publications

References 6 publications

Histological study of the Isotretinoin drug effect on the intrauterine prenatal development in the pregnant mice

Histological study of the Isotretinoin drug effect on the intrauterine prenatal development in the pregnant mice

Isotretinoin for Treating Acne Vulgaris

Contact Info

Product

Resources

About