Effect of preoperative administration of erythromycin or flunixin meglumine on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of left displacement of the abomasum

Abstract

Results suggested that preoperative administration of a single dose of erythromycin increased abomasal emptying rate, rumen contraction rate, and milk production in the immediate postoperative period in cows undergoing surgical correction of LDA.

Effects of erythromycin on milk yield, rumen contraction rate and blood beta-hydroxybutyrate concentration in dairy cows after laparoscopic reposition of the left displaced abomasum

“…From the literature it is known that cows with LAD have a reduced abomasal emptying rate which further decreases immediately after surgical correction (Wittek et al 2005). In a study by Wittek et al (2008a), abomasal emptying rate (D-xylose absorption test, pharmokokinetic T max model; group Emy vs control group: T max = 164 ± 64 min vs T max = 276 ± 72 min, P < 0.001), relative milk yield (baseline level at Day 0: group Emy vs control group: 7.5 ± 3.2 kg vs 8.9 ± 4.5 kg, P > 0.05; Day 1: 175 vs 125% of Day 0, P < 0.001; Day 2: 170 vs 125% of Day 0, P < 0.001) and RCR (group Emy vs control group, Day 1: 3.1 vs 1.9 contractions per 3 min) were increased significantly after reposition of LAD using laparotomy and omentopexy by a preoperative erythromycin administration using the same dosage as in our study. Therefore, in the present field trial we investigated whether positive effects on clinically easily measurable parameters (milk yield, BHB, RCR) after laparoscopic abomasopexy can be achieved with an erythromycin treatment.…”

“…Cows with signs of systemic illness (e.g. rectal temperature > 39.5 °C, clinical mastitis, watery diarrhoea or evidence of peritonitis during surgery) were excluded from the study as proposed by Wittek et al (2008a).…”

“…Erythromycin, a motilin receptor agonist (Ungemach 2010), is considered as the most effective prokinetic drug at the abomasum in both calves (Afshari et al 2009) and adult cattle (Wittek et al 2008a;Wittek et al 2008b;Wittek 2010;Constable et al 2012;Sanger et al 2013). Its suitability for the treatment of postoperative abomasal hypomotility after surgical correction of LAD or abomasal volvolus was shown by Wittek et al (2008a;Wittek et al 2008b). A single dose of erythromycin administered preoperatively had positive effects on abomasal emptying rate, rumen contraction rate (RCR) and milk yield after reposition of LAD by laparotomy and omentopexy in the immediate postoperative period (Wittek et al 2008a).…”

“…Its suitability for the treatment of postoperative abomasal hypomotility after surgical correction of LAD or abomasal volvolus was shown by Wittek et al (2008a;Wittek et al 2008b). A single dose of erythromycin administered preoperatively had positive effects on abomasal emptying rate, rumen contraction rate (RCR) and milk yield after reposition of LAD by laparotomy and omentopexy in the immediate postoperative period (Wittek et al 2008a). Erythromycin is a member of the macrolide antibiotic family (Kroker 2010).…”

Metabolic indicators and risk factors of left displaced abomasum in dairy cattle

“…Inhibition of abomasal motility may be major reason of DA. The prerequisite for DA is abomasal atony due to the accumulation of gas and fluid in the abomasum Michel et al 2003, Wittek et al 2008, Buehler et al 2008, Doll et al 2009. Displaced abomasa usually contain more methane (up to 70%) which is comparable to the rumen (Sarashina et al 1990, Doll et al 2009.…”