Effect of pretreatment dexamethasone on postendodontic pain

Pochapski, Márcia Thaís; Santos, Fábio André dos; Andrade, Eduardo Dias de; Sydney, Gilson Blitzkow

doi:10.1016/j.tripleo.2009.05.014

Cited by 77 publications

(107 citation statements)

References 24 publications

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“…Glucocorticoids are another class of drugs that prevent the production or release of inflammatory mediators. Previous studies have shown that dexamethasone can help reduce or prevent postoperative endodontic pain, regardless of the route of administration (single oral dose, periapical infiltration, or intraligamentary injection) 10,17,22) . Dexamethasone is well absorbed after oral administration and has a bioavailability of 61 to 86%.…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge, the optimal moment for oral administration of corticosteroids and their impact on increasing the success rate of IANB remain to be evaluated in clinical trials. According to the literature, a single oral dose of 4 mg dexamethasone is recommended to reduce post endodontic pain 17) . Therefore, in the present study, 4 mg dexamethasone was administered and no side effects subsequently observed.…”

mentioning

confidence: 99%

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Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

Bidar

Mortazavi

Forghani

et al. 2017

Bull. Tokyo Dent. Coll.

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The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine the effect of preoperative oral administration of ibuprofen or dexamethasone on the success rate of inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis. Seventy-eight patients with irreversible pulpitis were randomly divided into 3 groups (26 per group) and given one of the following at 1 hr prior to performing local anesthesia: a placebo; 400 mg ibuprofen; or 4 mg dexamethasone. Each patient recorded their pain level on a visual analog scale before taking the medication or placebo, at 15 min after completion of IANB, and during treatment if pain occurred. The success of the anesthesia was defined as no or mild pain at any stage during the endodontic procedure. The success rate of the IANB was 38.5, 73.1, and 80.8% with the placebo, ibuprofen, and dexamethasone, respectively. Both ibuprofen and dexamethasone were significantly more effective than the placebo. No significant difference was observed, however, between the two experimental medications in terms of effectiveness. The results of the present study suggest that premedication with ibuprofen or dexamethasone increases the success rate of an IANB in patients with symptomatic irreversible pulpitis in the mandibular molars.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

Bidar

Mortazavi

Forghani

et al. 2017

Bull. Tokyo Dent. Coll.

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“…Age, gender, and length of treatment are factors associated with increase risk of pain experienced during endodontic treatment procedures. 1,9, 10 Pathological inflammation or infection of the pulp and perapical can lower the pH of the tissue around the teeth. The degree of decrease in pH tissues surrounding area is varied and decrease pH will reduce the effects of anesthesia that go into a neural network since more RNH+ ion is formed than RN.…”

Section: Diagnosis: Process Of Identifying a Disease Ormentioning

confidence: 99%

Management pain and anxiety in endodontic treatment

Sumidarti

Dwiandhany

2017

J Dentomaxillofac Sci

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Objective : Dental pain is a common symptom that most often causes patient to seek dentist. A survey conducted by the American Association of Endodontics revealed that more than half patients who come to dentist have experienced pain, which originate from the teeth or of the surrounding tissue, can causes difficulties in handling, also the anxiety of the patient. Understanding the pain experienced by patient will help dentist to determine when to make an action. Most patient being fear with pain, so they delay to get treatment from dentist, and lead to the development of further infection and inflammation. The aim of this paper is to improve the understanding of pharmacology and procedures for pain and anxiety management in endodontic treatment. So, it is important to determine accurate diagnosis, management and drug administration.

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“…A recent systematic review showed that between 3% and 58% of patients were reported to have experienced endodontic postoperative pain (5). The management of postoperative pain has been the subject of many research studies, including preoperative explanations and instructions (6), long-acting anesthesia (7), the glide path (8), occlusal reduction (9, 10), medication using salicylic acid (11), non-steroid anti-inflammatory drugs (NSAIDs) (12), combination of ibuprofen and acetaminophen (13), narcotic analgesics (14), a combination of narcotic analgesics with aspirin (15) or acetaminophen (16), and steroidal anti-inflammatory drugs (17,18).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Preoperative Administration of Antihistamine, Analgesic and Placebo on Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Controlled Trial

Arslan¹,

Gundogdu²

2017

Eur Endod J

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Objective:To compare the effect of preoperative administration of an antihistamine, an analgesic, or a placebo on postoperative pain in maxillary molar teeth with symptomatic apical periodontitis. Design: A randomized, controlled trial. Methods: Population: A total of 51 patients with moderate-to-severe maxillary molar tooth pain who have undergone a root canal treatment. Intervention: Preoperative administration of either an antihistamine or an analgesic. Control: Versus placebo Outcomes: Reduction in postoperative pain? The data were analyzed with chi-square, one-way analysis of variance (ANOVA) and least significant difference (LSD) post-hoc tests. Results: At days 1 and 3, preoperative administration of the antihistamine and analgesic resulted in lower pain levels than the placebo. At days 5 and 7, however, while preoperative administration of the antihistamine still resulted in less pain than the placebo, there was no significant difference between the analgesic and placebo (P>0.05). Conclusion: Within the limitations of the present study, the preoperative administration of an antihistamine can be beneficial in reducing the postoperative pain of endodontic treatments.

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Effect of pretreatment dexamethasone on postendodontic pain

Cited by 77 publications

References 24 publications

Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study

Management pain and anxiety in endodontic treatment

The Effect of Preoperative Administration of Antihistamine, Analgesic and Placebo on Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Controlled Trial

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