Effect of pretreatment with ketorolac on propofol injection pain

Huang, Yu-guang; Buerkle, Hartmut; Lee, T. H.; Lu, Chien Lin; Lin, Cheng; Lin, Shaoyan; Chou, An‐Kuo; Muhammad, Rohaizak; Liu, Yang

doi:10.1034/j.1399-6576.2002.460816.x

Cited by 48 publications

(40 citation statements)

References 21 publications

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“…Não houve diferença significativa entre os grupos L e LF na redução da dor causada pela injeção de propofol (68% sem dor versus 70%; p > 0,05) (Figura 1). 14 , mas Scott e col. 17 sugeriram que seja conseqüência da ação de cascata enzimática, possivelmente a cascata da calicreína-cinina. Essa sugestão foi apoiada por Iwama e col. 17 , que demonstraram que o tratamento prévio com um inibidor da calicreína inibia a dor causada pela injeção de propofol.…”

Section: Resultsunclassified

Efeitos do tratamento prévio com lidocaína, paracetamol e lidocaína-fentanil por via venosa na dor causada pela injeção de propofol: estudo comparativo

El-Radaideh

2007

Rev. Bras. Anestesiol.

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RESUMOEl-Radaideh KM -Efeitos do Tratamento Prévio com Lidocaína, Paracetamol e Lidocaína-Fentanil por Via Venosa na Dor Causada pela Injeção de Propofol. Estudo Comparativo. JUSTIFICATIVA E OBJETIVOS:Foi realizado estudo duplamente encoberto, aleatório, para avaliar a eficácia do tratamento prévio, por via venosa, com lidocaína, paracetamol (Perfalgan) ou lidocaína associada ao fentanil na redução da dor causada pela injeção de propofol. MÉTODOS:Imediatamente após a oclusão venosa com torniquete de borracha foi feita a administração venosa de 4 mL de lidocaína a 1% (Grupo L, n = 50), 4 mL de paracetamol (Perfalgan) (40 mg) (Grupo R, n = 50), lidocaína a 2% associada a 100 µg de fentanil (Grupo LF, n = 50) ou 4 mL de solução fisiológica a 0,9% (Grupo P, n = 50; grupo-controle com placebo) a 200 adultos. A liberação da obstrução venosa foi feita após 60 segundos, sendo seguida da administração venosa de propofol, 2,5 mg.kg -1 a uma velocidade de 0,5 mg.s -1 através de cateter 20G inserido na veia do dorso da mão. A avaliação da dor foi feita durante a injeção de propofol. Ela incluiu movimentos da mão, expressão verbal espontânea de dor, caretas e gemidos durante a injeção de propofol. RESULTADOS:Lidocaína-fentanil (70% sem dor) e lidocaína (68% sem dor) foram mais eficazes na redução da dor causada pela injeção de propofol do que o paracetamol (54% sem dor) e o placebo (36% sem dor) (p < 0,05). A diferença na redução da incidência de dor causada pela injeção de propofol entre a lidocaína e lidocaí-na-fentanil não foi significativa. O paracetamol foi muito superior ao placebo (p < 0,05). CONCLUSÕES:O propofol é um anestésico amplamente utilizado. Lidocaína e lidocaína-fentanil administrados como tratamento prévio, na forma de retenção venosa durante 60 segundos, antes da administração do propofol reduziram de forma acentuada a dor causada pela injeção de propofol, enquanto o paracetamol (Perfalgan) reduziu discretamente essa mesma dor.Unitermos: ANESTÉSICOS, Venoso: propofol; COMPLICAÇÕES, dor à injeção.

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Section: Resultsunclassified

Efeitos do tratamento prévio com lidocaína, paracetamol e lidocaína-fentanil por via venosa na dor causada pela injeção de propofol: estudo comparativo

El-Radaideh

2007

Rev. Bras. Anestesiol.

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“…Niazi et al [18] informed that the pain shall be reduced or delayed only when total infused injection rate is 10-20 sec. Huang et al [19] in their study, indicated that infusing IV liquid through cannulation effects the pain, and also fast moving liquid reduces contact to the vein periphery by diluting propofol and causes less pain. In our study, injection rate is adjusted in a way to administer 40 mg propofol in every 10 minutes, pain incidence inquiry has been performed nearly up to 30 seconds after injection (after 1/4, 2/4 and 3/4 of total propofol dose have been infused) and as this is in accordance with the injection rate specified in literature.…”

Section: Discussionmentioning

confidence: 99%

Comparison of hemodynamic response for intubation and propofol pain caused by lidocaine administration with infusion and tourniquet

Deniz¹,

Alparslan²,

Ak³

et al. 2017

Med-Science

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Propofol is one of the most widely used i.v. anesthetic agent. Nevertheless, pain following i.v. administration of propofol is an important problem in anesthesia induction. A wide range of studies have been performed related to lidocaine effects on propofol injection pain and hemodynamic response to intubation. However, effect of both situations are seldomly studied in the literature. In our study we compare lidocaine effects on propofol injection pain and hemodynamic response to intubation which is given by infusion or under tourniquet as i.v. bolus. 70 patients attended to the study are separated randomly into two groups of 35 patients. Prior to induction, lidocaine has been infused with infusion pump as to be completed in 2 minutes with concentration of 2%, total dosed 1mg/kg in infusion group (Group I, n=35). In this group, after half of the total lidocaine dose is infused (1st minute), anesthesia induction has been started by giving 40 mg propofol of 1% in 10 seconds with infusion pump. In tourniquet group (Group T, n=35) prior to induction 1mg/kg lidocaine has been given as bolus by applying tourniquet with 70 mm/Hg pressure to the arm that is established vascular access and tourniquet has been remained for 60 seconds. After opening the tourniquet, induction has been started by giving 40 mg propofol of 1% in 10 seconds with infusion pump. During induction, patient"s consciousness was evaluated by questioning his/her name and age after administering 1/4 (VRS0), 1/2 (VRS1), and 3/4 (VRS2) of total propofol dose. Confused patients were eliminated and the sense of pain caused by propofol was evaluated in study patients. The results were recorded according to four-point categorical verbal rating scale (VRS). For groups, the pulse rates and mean arterial pressures before lidocaine administration (T0), after lidocaine (T1), immediately after intubation (T2) and 10th minute after intubation (T3) were recorded. No differences detected among the groups with regards to demographic data and side effects. (p>0.05). No significant differences statically detected when comparing the heart rate (HR), mean arterial pressure (MAP) and pain scores of groups for all times (p>0.05). It is concluded that administering lidocaine by infusion technic may be an alternative method for tourniquet method on suppressing hemodynamic response related to tracheal intubation and on preventing injection pain related to propofol.

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“…[2,4,[14][15][16][17] Hovewer, even in patients who received most popular lidocaine treatment, the incidence of pain has been reported as frequent as 32%-48%. [15] Propofol is an excellent anesthetic that belongs to the group of phenols, which can irritate the skin, mucous membrane and venous intima.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.

E¹,

Titiz²,

Akpek³

et al. 2013

Agri

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SummaryObjectives: Propofol causes considerable pain upon injection, although different methods and propofol formulations have been used to decrease this pain. We aimed to investigate the effect of i.v. esmolol pretreatment on propofol injection pain.Methods: Ninety ASA I-II patients undergoing elective surgery under general anesthesia were randomly assigned into three groups of thirty each. A 20 G cannula was inserted into the dorsum of the nondependent hand. After venous occlusion for one minute, groups E, L and S were pretreated with 5 mg/ml (total 2 ml) esmolol, 40 mg lidocaine and 2 ml saline i.v. respectively. After release of venous occlusion, one fourth of the total propofol dose was administered at a rate of 0.5 ml/sec. During the injection of both pretreatment solution and propofol, patient pain was assessed by using 4 point scale. Heart rate and noninvasive arterial blood pressure values were recorded before induction, just after entubation and five minutes after entubation. Results:Demographic values were similar among groups. Incidence of pain on injection of propofol in the control, esmolol and lidocaine groups was 90%, 33.3%, 50% respectively (p<0.05). Heart rate, systolic arterial pressure, and diastolic arterial pressure values were not different between the groups.Conclusion: Pretreatment with low dose esmolol i.v. seems to be effective in attenuating pain during propofol injection.

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Effect of pretreatment with ketorolac on propofol injection pain

Abstract: Our results suggested that pretreatment with i.v. 15 and 30 mg ketorolac reduces pain following propofol injection. Moreover, pretreatment with i.v. ketorolac 10 mg with venous occlusion for 120 s achieves the same pain relief effect.

Cited by 48 publications

References 21 publications

Efeitos do tratamento prévio com lidocaína, paracetamol e lidocaína-fentanil por via venosa na dor causada pela injeção de propofol: estudo comparativo

Efeitos do tratamento prévio com lidocaína, paracetamol e lidocaína-fentanil por via venosa na dor causada pela injeção de propofol: estudo comparativo

Comparison of hemodynamic response for intubation and propofol pain caused by lidocaine administration with infusion and tourniquet

Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.

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