Effect of Probiotic “L.Reuteri” Association on the Reduction of Serum Bilirubin in Neonatal Jaundice

Makhoul, G.; Mardini, Joelle; Ojaimi, Mode Al; AbiFares, G.; Hanna, Paul; Alameddine, Abdallah K.; Feghali, H.; Makhoul, Peter; Saaybi, J.; Georges, Nicolas; Sakka, J.; Khalife, Marie-Claude Fadous

doi:10.19044/esj.2018.v14n12p384

Cited by 6 publications

(9 citation statements)

References 12 publications

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“…12 Though phototherapy is in practice for more than 50 years, its complications predominantly hypocalcemia put a limit to its prolonged use 12,13 . Therefore measures which can reduce the length of phototherapy are hot focus of research [4][5][6][7] . Recent studies claimed that probiotics supplementation of jaundiced neonates significantly reduced the mean duration of phototherapy and advocated its preferred use in future practice 6,7 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore measures which can reduce the length of phototherapy are hot focus of research [4][5][6][7] . Recent studies claimed that probiotics supplementation of jaundiced neonates significantly reduced the mean duration of phototherapy and advocated its preferred use in future practice 6,7 . However, there was controversy in the existing literature [8][9][10] while there was no such local published material which necessitated the present study.…”

Section: Discussionmentioning

confidence: 99%

“…During the past decade, probiotics has gained much popularity 3 and their clinical use has seen a significant rise where there are reports of their benefit in patients with acute and chronic diarrhea 4 and pneumonia. 5 There has been studies investigating their role in the clinical management of neonates with hyperbilirubinemia 6,7 but with controversial results. [8][9][10] Torkaman et al 8 (2017) reported that mean duration of phototherapy was significantly shorter in neonates receiving probiotics in addition to phototherapy as compared to neonates receiving phototherapy alone (3.13±0.70 vs. 3.55±0.74 days; p-value<0.001) in Iran.…”

Section: Introductionmentioning

confidence: 99%

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Role of Probiotics in Neonates with Hyperbilirubinemia Receiving Phototherapy

Tariq¹,

Shahman²,

Mateen³

et al. 2021

PJMHS

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Study Objectives: To compare the mean duration of phototherapy in neonates with hyperbilirubinemia receiving phototherapy with vs. without probiotics. Study Design and Settings: It was a randomized controlled trial carried at Department of Pediatrics, DHQ Hospital Kasur from Jan 2021 to June 2021. Patients and Methods: The present research involved 94 neonates of both genders aged between 2 to 28 days of life diagnosed of neonatal hyperbilirubinemia (serum bilirubin level ≥15mg/dL and direct bilirubin level ≤1.5 mg/dL). These neonates were allocated into two groups randomly. Neonates in Group-I were given probiotics along with conventional treatment of phototherapy whereas neonates in Group-II received conventional phototherapy alone. Study outcome was described in terms of mean duration of phototherapy (phototherapy was stopped when serum bilirubin level was less than 10 mg/dl during the ﬁrst week and less than 11 mg/dl after the first week) which was recorded and compared between the groups. An informed written consent was taken from parents of every neonate. Results of the Study: The mean age of the neonates was 6.54±4.96 days while the mean gestational age was 37.31±2.04 weeks. There were 55 (58.5%) baby boys and 39 (41.5%) baby girls with a boys to girls ratio of 1.4:1. The mean weight of the neonates was 2.89±0.49 Kg while the mean serum bilirubin level upon admission was 16.73±1.19 mg/dl. The mean duration of phototherapy was significantly shorter in neonates receiving probiotics along with phototherapy as compared to phototherapy alone (3.13±0.92 vs. 3.81±1.12 days; p=0.002). Similar significant difference was observed across various subgroups based on age, gender, gestational age, weight and serum bilirubin level upon admission. Conclusion: Addition of probiotics to conventional practice of phototherapy alone in jaundiced neonates was found to hasten the recovery evident from significant reduction in the mean duration of phototherapy advocating its routine use in future practice. Keywords: Neonatal Hyperbilirubinemia, Phototherapy, Probiotics

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Probiotics in Neonates with Hyperbilirubinemia Receiving Phototherapy

Tariq¹,

Shahman²,

Mateen³

et al. 2021

PJMHS

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“…Jaundice is one of the most commonly encountered symptoms during the neonatal period and one of the leading causes of admissions in newborn nurseries throughout the world 2) . Jaundice in newborns occurs due to high levels of unconjugated bilirubin in the blood that causes by ABO/Rhesus incompatibility, G6PD deficiency, infections, prematurity, and metabolic disorders 3) . The etiology of neonatal hyperbilirubinemia is multifactorial, such as physiological factors, isoimmunization, and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Roles of Probiotics in Reduction of Neonatal Jaundice in Term Newborns

Santosa

Shoji

Itoh

et al. 2022

Juntendo Medical Journal

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Objective: the primary objective was to examine the effect of Bifidobacterium on decreasing the bilirubin level in term neonates delivered by Caesarean Section (CS). Materials and Methods:A total of 153 healthy term neonates delivered by CS were included in this study and were divided into the non-probiotic group (n=99) and probiotic group (n=54) based on the history of probiotics administration. There were no infants who underwent phototherapy. A total of 20 doses of probiotics were given orally from the first day of life. The transcutaneous bilirubin (TcB) levels were measured every day for the first 5 days of life. Data of each infant and mother were gathered from medical records. Results:The bilirubin level per day (day-1 to day-5) in the non-probiotic group was no different from the probiotic group.Differences in bilirubin level between day-5 and day-1, and also between day-5 and day-2 were not different between the two groups. There was a significant (p = 0.03) body weight gain in the probiotic groups with a mean of 36.09 ± 8.23 gram/day. No obvious adverse reactions were seen in both the non-probiotic group and probiotic group. Conclusions:Our findings suggest no significant effects of probiotics on lowering bilirubin levels in the first five days of life. Also, probiotics have a positive effect on body weight gain in healthy term infants, and it is safe to be given to newborns.

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“…7 However, it can also cause some undesirable effects in newborns such as hyperthermia, erythematous rashes, burns, and diarrhea if the treatment is prolonged. 8 Extreme levels of bilirubin in the body can cause kernicterus or even death. If bilirubin levels are not reduced with phototherapy, exchange transfusion is the treatment for severe hyperbilirubinemia in order to prevent kernicterus.…”

Section: Introductionmentioning

confidence: 99%

Effect of Addition of Probiotics to Standard Treatment on Neonatal Jaundice

Afzal

Butt

Munir

et al. 2021

Ann Pak Inst Med Sci

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Objective: To compare the mean change in the bilirubin levels with addition of probiotics to standard treatment for the management of neonatal jaundice. Methodology: The randomized controlled trial was undertaken at the Neonatal Intensive Care Unit of the Paediatrics Department, Federal Government Polyclinic (Post Graduate Medical Institute), Islamabad from 1st April to 30th September 2019. Neonates with hyperbilirubinemia requiring phototherapy were randomly divided into two groups, each having 30 patients. Group A received probiotics along with phototherapy while group B received phototherapy alone. Primary outcome was serum total bilirubin, which was calculated on 0, 1 and 3 days of treatment. Duration of phototherapy and patient's outcome was also recorded. Data was analyzed statistically using SPSS v. 23. Results: The mean serum bilirubin level after 24 hours was 14.27 ± 4.35 mg/dl in combination group while 16.43 ± 4.36 mg/dl in phototherapy group (p > 0.05). After 48 hours, the mean serum bilirubin level was 12.37 ± 3.33 mg/dl in combination group while 14.09 ± 3.60 mg/dl in phototherapy group (p > 0.05). After 72 hours, the mean serum bilirubin level was 11.09 ± 2.87 mg/dl in combination group while 11.72 ± 2.96 mg/dl in phototherapy group (p > 0.05). The mean time required of blue light phototherapy was 43.47 ± 20.71 hours in combination group while 61.53 ±28.27 hours in phototherapy group (p < 0.05). All neonates were discharged. Conclusion: Addition of probiotics to standard treatment decreased the time required for the phototherapy in neonatal jaundice. However no statistically significant difference was seen in the bilirubin levels between the two groups.

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Effect of Probiotic “L.Reuteri” Association on the Reduction of Serum Bilirubin in Neonatal Jaundice

Cited by 6 publications

References 12 publications

Role of Probiotics in Neonates with Hyperbilirubinemia Receiving Phototherapy

Role of Probiotics in Neonates with Hyperbilirubinemia Receiving Phototherapy

Roles of Probiotics in Reduction of Neonatal Jaundice in Term Newborns

Effect of Addition of Probiotics to Standard Treatment on Neonatal Jaundice

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