Effect of Probiotics and Breastfeeding on the Bifidobacterium and Lactobacillus/Enterococcus Microbiota and Humoral Immune Responses

Rinne, Minna; Kalliomäki, Marko; Arvilommi, Heikki; Salminen, Seppo; Isolauri, Erika

doi:10.1016/j.jpeds.2005.03.053

Cited by 134 publications

(106 citation statements)

References 33 publications

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“…; however, effects of feeding on Lactobacillus abundance are inconsistent across other studies. Increased proportions of Lactobacillus, 25,26,48,54 as well as greater abundances of L. gasseri 28,47 in BF compared to FF infants have been reported, whereas other studies found opposite results 16,52,53 or reported intergroup variability and instability over time. 27,43 A greater prevalence 15 and higher proportion 24 and total counts 16,46 of C. difficile in FF compared to BF infants, as well as, significantly more Peptostreptococcaceae, 31 Akkermansia, 15 Veillonella, and Enterococcus 28 have been described.…”

Section: (Finland)mentioning

confidence: 95%

“…Bifidobacteria have been shown to account for 70% of the sequences of exclusively breastfed (EBF) infants 40 and appear earlier in the feces of EBF than in FF infants 38 In addition, infants who were exclusively breastfed in early life maintained greater colonization with bifidobacteria later in infancy. 54 Although this evidence is substantial, other findings suggest that Bifidobacterium exists in similar proportions 18,34 and numbers 44,46 in BF and FF infants and dominate the microbiota across both groups. 34,50,51 Conversely, Palmer and colleagues 2 reported very low levels of bifidobacteria in all infants with varied dietary patterns; however, these findings are likely due to the 8F universal primer that was used in the study having a three base pair mismatch against B. longum, and that Bifidobacterium genus in general does not have 100% sequence identity to the 8F primer sequence.…”

Section: (Finland)mentioning

confidence: 96%

“…Additional studies investigating the long-term impacts of early feeding regimes on GI profiles beyond infancy are also necessary, as existing evidence has demonstrated that infants who were fed with HM for at least 50% of feedings during the first 3 mos of life maintained a different fecal microbial composition between 12 and 24 mos than those who had received less than 50% of feedings from HM. 54 In future studies, it will be important to carefully document the relative proportions of HM and formula the MF infant is consuming in addition to when the formula was introduced to the infant. For example, the microbiota of an infant who was mixed-fed from birth would likely differ from an infant who was exclusively breastfed from birth until 3 mos of age at which time formula was introduced.…”

Section: (Finland)mentioning

confidence: 99%

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The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

2017

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The development of the human infant intestinal microbiota is a sequential process that begins in utero and continues during the first 2 to 3 years of life. Microbial composition and diversity are shaped by host genetics and multiple environmental factors, of which diet is a principal contributor. An understanding of this process is of clinical importance as the microbiota acquired in early life influence gastrointestinal, immune and neural development, and reduced microbial diversity or dysbiosis during infancy is associated with disorders in infancy and later childhood. The goal of this article was to review the published literature that used culture-independent methods to describe the development of the gastrointestinal microbiota in breast-and formula-fed human infants as well as the impact of prebiotic and probiotic addition to infant formula, and the addition of solid foods.

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Section: (Finland)mentioning

confidence: 95%

Section: (Finland)mentioning

confidence: 96%

Section: (Finland)mentioning

confidence: 99%

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The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

2017

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“…Similar increases in faecal IgA, following probiotic treatment, has been observed in human infants (Fukushima et al, 1998;Rinne et al, 2005). These studies have been aimed at using probiotics to ameliorate the symptoms of food allergy.…”

Section: Probiotic Actions On Host Physiologymentioning

confidence: 68%

Probiotics – do they have a role in the pig industry?

Kenny

Smidt

Mengheri

et al. 2011

Animal

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The delivery of certain living microorganisms in food has long been suggested as having positive health effects in humans. This practice has extended into food animal production, with a variety of microorganisms being used; lactic acid bacteria, variousBacillusspecies and the yeastSaccharomyces cerevisiaehave been particularly used in the pig industry. The increased interest in probiotics is essentially due to the problem of microbial resistance to antibiotics and following the ban of the use of antibiotics in animal production, probiotics being considered an alternative means to reduce pathogen infection and improve animal health especially around the time of weaning. However, there is still a need to clarify the probiotic effectiveness in pigs, and the underlying mechanisms. When assessing the efficacy of probiotics one must consider the particular strain of organism being used and the production stage of the pigs being treated. The reproducible delivery of probiotics in industrial pig production is problematic as maintenance of viability is key to their beneficial activity, but difficult to achieve with commonly used feed processing technologies. One specific context where probiotics organisms may be reliably delivered is in systems utilising fermented liquid feeds. Liquid feed may be fermented by the activity of wild lactic acid bacteria or may be stimulated using specific isolates as ‘starters’; the latter system has advantages in terms of reproducibility and speed of fermentation. The farm context in which the organism is used is likely to be critical; the use of probiotics is more likely to result in measurable economic gains in animals living in sub-optimal conditions rather than in those reared in the highest welfare and husbandry conditions. The establishment of a beneficial lactic acid bacteria population at birth may lead to healthier animals, this may be most effectively achieved by treating sows, which provide an amplification step and flood the neonatal pigs’ environment with desirable bacterial strains. In contrast, it may be sufficient to provide a supportive, protective microbiota around the time of weaning as this is a time of major crisis with instability and loss of certain bacterial populations.

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“…Previous demonstrations suggest that the gut microbiota composition is linked to the immunological and metabolic development of the child (Guarner and Malagelada, 2003;Rinne et al, 2005). The current intervention study targeted at dietary elements is associated with these developmental components, specifically at the dietary low-fibre and high saturated fat composition, together with aberrant gut microbiota development by probiotics.…”

Section: Introductionmentioning

confidence: 99%

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

et al. 2010

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Objectives: To evaluate the impact of maternal diet and intensive dietary counselling during pregnancy and breastfeeding on the infant's metabolic status. Subjects/Methods: At the first trimester of pregnancy, 256 women were randomized into a control/placebo group and two dietary counselling groups (diet/probiotics and diet/placebo). The counselling, with double-blind randomization to probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis) or placebo, targeted excessive saturated fat and low fibre consumption. Maternal diet was evaluated repeatedly during pregnancy and postpartum by means of 3 days' food diaries. Metabolic markers, serum 32-33 split and intact proinsulin, leptin/adiponectin ratio, skinfold thickness and waist circumference were measured of 194 healthy infants at the age of 6 months, and the high levels were taken to mirror adverse metabolic status. Results: The proportion of infants with a high 32-33 split proinsulin was significantly lower in dietary counselling with probiotics (n ¼ 6/62, 9.7%) or placebo (n ¼ 7/69, 10.1%) compared with the control/placebo group (n ¼ 17/63, 27.0%). The high split proinsulin was associated with larger skinfold thickness, waist circumference and higher leptin/adiponectin ratio in the infants (Po0.05). With respect to maternal diet during pregnancy, the highest and lowest tertiles of fat intake increased the infant's risk of high split proinsulin, whereas those of butter associated correspondingly with the infant's waist circumference. Further, breastfed infants showed a reduced risk of high split proinsulin and leptin/adiponectin ratio compared with formula-fed infants. Conclusions: Modification of maternal diet during pregnancy and breastfeeding may benefit infant metabolic health. High split proinsulin reflects adverse metabolic status in infancy, which can be improved by early dietary counselling.

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Effect of Probiotics and Breastfeeding on the Bifidobacterium and Lactobacillus/Enterococcus Microbiota and Humoral Immune Responses

Cited by 134 publications

References 33 publications

The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

Probiotics – do they have a role in the pig industry?

Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study

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