Effect of probiotics on length of hospitalization in mild acute pancreatitis: A randomized, double-blind, placebo-controlled trial

Wan, Yong; Bian, Zhong-Zheng; Sun, Tongwen

doi:10.3748/wjg.v27.i2.224

Cited by 17 publications

(10 citation statements)

References 24 publications

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“…Through basic research and clinical trials, progress has been made in characterizing acute pancreatitis, which provides a basis for clinical treatment, but there are still many mechanisms of this disease that have not been fully elucidated. Many treatment options require clinical verification, and many potential therapeutic targets need to be tested in clinical trials [ 18 – 20 ]. At present, there are few studies on the genes and molecules related to the pathogenesis and progression of noncalculous biliary acute pancreatitis, either domestically or abroad, which limits the ability of healthcare providers to accurately diagnose and treat such cases of pancreatitis in the clinic.…”

Section: Discussionmentioning

confidence: 99%

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis

Sun

Wang

Hao

et al. 2021

Gastroenterology Research and Practice

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Background. To provide a basis for the diagnosis and treatment of acalculous biliary pancreatitis, this study investigated the impact of serum metabolites on the pancreatic transcriptome in acute acalculous cholecystitis (AAC). Methods. Fourteen rabbits were randomly divided into two groups (a normal control group of 7 rabbits and an AAC group of 7 rabbits), blood was collected from the 14 rabbits, and metabolomic analysis was performed through 1H NMR. Two pancreatic tissue chips of the AAC group and the normal control group were prepared and sequenced. We utilized the limma package of R software, the DAVID database, the STRING database, Cytoscape software, and the CFinder analysis tool to perform differential expression gene analysis, gene function enrichment analysis, protein interaction network (PPI) construction, and network module mining, and we performed gene enrichment analysis in each module. Results. Serum metabolism analysis showed that in AAC, the metabolism of sugar, lipids, and protein, that is, the three major nutrients, was affected to varying degrees, and levels of serum trimethylamine N-oxide (TMAO) increased. Bioinformatic methods were utilized to identify a total of 183 differentially expressed genes and 3 key genes. Enrichment analysis showed that differentially expressed genes were significantly enriched in cation transport, the inflammatory response, the NF-κB pathway, and the cancer signaling pathway. Conclusion. Metabolomic analysis and functional analysis of 3 key genes demonstrated that abnormal serum metabolites affected the pancreatic transcriptome and induced a sensitive state of inflammation in the pancreas. These metabolites may represent important targets for future research on the pathogenesis, clinical diagnosis, and treatment of noncalculous biliary pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis

Sun

Wang

Hao

et al. 2021

Gastroenterology Research and Practice

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“…The consumption of a mixed probiotic preparation containing Bacillus subtilis and Enterococcus faecium reduced the percentage of pancreatic sepsis, multiple organ dysfunction syndrome, and mortality (180). Furthermore, the intake of the same probiotic mix reduced the length of hospital stay of patients with MAP, although no statistical difference was seen in recurrent abdominal pain between the probiotic and placebo group (181).…”

Section: Pancreatitis and Probioticsmentioning

confidence: 99%

Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target

et al. 2022

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Pancreatic-related disorders such as pancreatitis, pancreatic cancer, and type 1 diabetes mellitus (T1DM) impose a substantial challenge to human health and wellbeing. Even though our understanding of the initiation and progression of pancreatic diseases has broadened over time, no effective therapeutics is yet available for these disorders. Mounting evidence suggests that gut dysbiosis is closely related to human health and disease, and pancreatic diseases are no exception. Now much effort is under way to explore the correlation and eventually potential causation between the gut microbiome and the course of pancreatic diseases, as well as to develop novel preventive and/or therapeutic strategies of targeted microbiome modulation by probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT) for these multifactorial disorders. Attempts to dissect the intestinal microbial landscape and its metabolic profile might enable deep insight into a holistic picture of these complex conditions. This article aims to review the subtle yet intimate nexus loop between the gut microbiome and pancreatic diseases, with a particular focus on current evidence supporting the feasibility of preventing and controlling pancreatic diseases via microbiome-based therapeutics and therapies.

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“…Additionally, Lactobacillus royale , Saccharomyces boulardii , and Bifidobacterium have been reported to inhibit BT and decrease the incidence of PALI ( 46 , 147 – 150 ). A double-blind clinical trial demonstrated that the time of hospitalization and abdominal pain is shortened in SAP patients following Bacillus subtilis and Enterococcus faecalis supplement ( 151 ). Similar to probiotics, prebiotics such as galactooligosaccharides, lactosucrose, and inulin-type fructan can substantially repair the functions of the intestinal barrier in SAP rats and have shown therapeutic potential in PALI ( 152 – 155 ).…”

Section: Interventions By Regulating the Intestinal Microbiotamentioning

confidence: 99%

Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury

Wang

Liu

et al. 2022

Front. Immunol.

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Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general surgery, is characterized by acute and rapid onset as well as high mortality, which often leads to multiple organ failure (MOF). Acute lung injury (ALI), the earliest accompanied organ dysfunction, is the most common cause of death in patients following the SAP onset. The exact pathogenesis of ALI during SAP, however, remains unclear. In recent years, advances in the microbiota-gut-lung axis have led to a better understanding of SAP-associated lung injury (PALI). In addition, the bidirectional communications between intestinal microbes and the lung are becoming more apparent. This paper aims to review the mechanisms of an imbalanced intestinal microbiota contributing to the development of PALI, which is mediated by the disruption of physical, chemical, and immune barriers in the intestine, promotes bacterial translocation, and results in the activation of abnormal immune responses in severe pancreatitis. The pathogen-associated molecular patterns (PAMPs) mediated immunol mechanisms in the occurrence of PALI via binding with pattern recognition receptors (PRRs) through the microbiota-gut-lung axis are focused in this study. Moreover, the potential therapeutic strategies for alleviating PALI by regulating the composition or the function of the intestinal microbiota are discussed in this review. The aim of this study is to provide new ideas and therapeutic tools for PALI patients.

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Effect of probiotics on length of hospitalization in mild acute pancreatitis: A randomized, double-blind, placebo-controlled trial

Cited by 17 publications

References 24 publications

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis

Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target

Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury

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