Effect of Probiotics on Oral Candidiasis: A Systematic Review and Meta-Analysis

Mundula, Tiziana; Ricci, Francesca; Barbetta, Beatrice; Baccini, Michela; Amedei, Amedeo

doi:10.3390/nu11102449

Cited by 47 publications

(41 citation statements)

References 75 publications

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“…Bacteria commensally living in the environment of the human organism developed the property of modulating the host’s immune response. They can influence the production of cytokines and antibodies and increase the pool of regulatory T lymphocytes [ 23 ]. Lactobacillus strains have the ability to induce cytokine synthesis by the inflammatory cells.…”

Section: The Mechanism Of Action Of Probiotics In the Oral Cavitymentioning

confidence: 99%

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The immunomodulating role of probiotics in the prevention and treatment of oral diseases

Kaźmierczyk-Winciorek

Nędzi-Góra

Słotwińska

2021

cejoi

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Probiotics are defined as non-pathogenic live microorganisms which, when administered in appropriate amounts, are beneficial to the health of the host. Currently, the group of probiotic microorganisms includes bacteria that produce lactic acid of the genera Lactobacillus and Bifidobacterium, belonging to the so-called LAB (lactic acid bacteria) groups, and the yeast Saccharomyces boulardii. Probiotics have a protective role in Candida spp. oral infection and especially colonization. Lactobacillus limits the progression of chronic periodontitis by inhibiting the secretory activity of Th17 lymphocytes, which in the pathogenesis of this disease are responsible for an excessive cytokine response causing adverse changes in periodontal tissues. A meta-analysis of the results of studies on the clinical evaluation of the effectiveness of probiotics in the treatment of gingivitis showed that the use of probiotics improved the condition of the gums in the course of the therapeutic process. Regular use of probiotics during orthodontic treatment significantly reduces the number of bacteria from the Streptococcus mutans group in the patient's saliva and significantly inhibits the expression of inflammatory mediators and an excessive immune response. The main mechanisms of the action of probiotics, such as elimination and inhibition of the growth of pathogenic microorganisms through competition for receptor sites and the secretion of metabolites with antibacterial activity, as well as the stimulation of specific and non-specific immune responses by activating T lymphocytes, and stimulating the production of cytokines, make it possible to also effectively use pro-health bacteria in oral diseases.

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Section: The Mechanism Of Action Of Probiotics In the Oral Cavitymentioning

confidence: 99%

“…This study systematically reviewed the effects of the intake of probiotics on oral candidiasis and concluded that this treatment had a beneficial effect on reducing oral Candida spp. counts [ 23 ].…”

Section: Probiotics and Oral Candidiasismentioning

confidence: 99%

The immunomodulating role of probiotics in the prevention and treatment of oral diseases

Kaźmierczyk-Winciorek

Nędzi-Góra

Słotwińska

2021

cejoi

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“…Postbiotic supplementation derived from Lactobacillus paracasei was able to protect G. mellonella infected with C. auris and immunomodulate indicating a dual role in modulating host immune response [ 129 ]. Even meta-analysis is among the first study of such kind which establishes the effect of probiotics on oral candidiasis [ 130 ].…”

Section: Targeted Microbial Therapymentioning

confidence: 99%

Understanding Human Microbiota Offers Novel and Promising Therapeutic Options against Candida Infections

et al. 2021

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Human fungal pathogens particularly of Candida species are one of the major causes of hospital acquired infections in immunocompromised patients. The limited arsenal of antifungal drugs to treat Candida infections with concomitant evolution of multidrug resistant strains further complicates the management of these infections. Therefore, deployment of novel strategies to surmount the Candida infections requires immediate attention. The human body is a dynamic ecosystem having microbiota usually involving symbionts that benefit from the host, but in turn may act as commensal organisms or affect positively (mutualism) or negatively (pathogenic) the physiology and nourishment of the host. The composition of human microbiota has garnered a lot of recent attention, and despite the common occurrence of Candida spp. within the microbiota, there is still an incomplete picture of relationships between Candida spp. and other microorganism, as well as how such associations are governed. These relationships could be important to have a more holistic understanding of the human microbiota and its connection to Candida infections. Understanding the mechanisms behind commensalism and pathogenesis is vital for the development of efficient therapeutic strategies for these Candida infections. The concept of host-microbiota crosstalk plays critical roles in human health and microbiota dysbiosis and is responsible for various pathologies. Through this review, we attempted to analyze the types of human microbiota and provide an update on the current understanding in the context of health and Candida infections. The information in this article will help as a resource for development of targeted microbial therapies such as pre-/pro-biotics and microbiota transplant that has gained advantage in recent times over antibiotics and established as novel therapeutic strategy.

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“…S.mutans is the most common organism that leads to the development of caries (nikawa et al, 2004;Beighton, 2005). S.mutans is an acidogenic bacteria and it rapidly metabolizes carbohydrates resulting in lowering of ph in the oral cavity that leads to disturbance in hemostasis in the oral microbial community (hedberg et al, 2008).…”

Section: Role Of Probiotics In Oral Healthmentioning

confidence: 99%

“…(Seminario-Amez et al, 2017). hu et al and Mundula et al, studied that the probiotics had a favourable effect in treating oral candidiasis(hu et al, 2019) (Mundula et al, 2019).…”

Section: Name Of the Commercial Productmentioning

confidence: 99%

Probiotics in Prevention of Dental Caries - A Literature Review

S.K¹

2020

Biosci. Biotech. Res. Comm

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Dental caries is a microbial disease induced by oral biofilm containing Streptococcus mutans, leading to destruction of tooth structure. With better understanding of the Ecology and microbiology of the oral cavity and with the advent of Minimal Invasive Dentistry, there has been a shift in the treatment modalities of caries. Recently probiotics have been used extensively to promote a healthy oral flora. This review article aims to promote a better understanding of the probiotic strains, their mechanism of action and the various modes of delivery available. An electronic search was also performed using databases such as Google scholar, PubMed, Science direct and Scopus. Comparisons of different searches were carried out to delete the repeated studies. The articles published in any language other than English were excluded. Several studies proved that Probiotics can influence the caries balance locally through a direct contact with oral tissues and systemically through the gastrointestinal tract. Most of the probiotic strains currently available have been proved safe and promote both general and oral health. There are limited clinical trials with widely different study designs and target population. Also there is lack of evidence, regarding sustainability of the effect of Probiotics.

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Effect of Probiotics on Oral Candidiasis: A Systematic Review and Meta-Analysis

Cited by 47 publications

References 75 publications

The immunomodulating role of probiotics in the prevention and treatment of oral diseases

The immunomodulating role of probiotics in the prevention and treatment of oral diseases

Understanding Human Microbiota Offers Novel and Promising Therapeutic Options against Candida Infections

Probiotics in Prevention of Dental Caries - A Literature Review

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