Nimonic C263 is a super alloy and it is difficult to cut. As this alloy possess high proportion of chromium, cobalt, and molybdenum, which fortify the material by solution hardening, which inhibits the dislocation movement, resulting in higher plastic deformation. In this research, an attempt has been made to model, analysis and investigate the machining characteristics such as thrust force, temperature at drill cutting edge, flank wear and surface finish during drilling of this alloy using silver nano fluid mixed Minimum Quantity Lubrication (MQL) environment. Residual stress at various combinations of process parameters was also observed and discussed. RSM based empirical models of the process parameters and optimization of multi response was developed. Thrust force, Temperature at drill cutting edge, surface roughness and tool wear affected by feed rate (percentage of contribution-60%), spindle speed (percentage of contribution-88.63%), spindle speed (percentage of contribution-71.42%) and feed rate (percentage of contribution-67.76%) respectively followed by other parameters.