Effect of prolonged hospitalization for threatened preterm labor on maternal and fetal vitamin D levels

Yonetani, Naoto; Kaji, Tatsuru; Hichijo, Atsuko; Nakayama, Sosogu; Maeda, Keisuke; Irahara, Minoru

doi:10.1111/jog.13620

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…The assessment criteria for vitamin D deficiency/insufficiency proposed by the expert panel was as follows: 25(OH)D equal to or above 30 ng/mL was considered to be vitamin D sufficient; 25(OH)D less than 30 ng/mL but not less than 20 ng/mL was considered to be vitamin D insufficient; 25(OH)D less than 20 ng/mL was considered to be vitamin D deficient. Low maternal 25(OH)D has been reported among Japanese pregnant women [17][18][19][20][21][22][23], even though the assessment criteria for vitamin D deficiency/insufficiency among pregnant women has not been defined yet. The proposed assessment criteria have mentioned that different criteria may be needed for pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Takaoka¹,

Nishida²,

Sairenchi³

et al. 2020

PLoS ONE

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Objectives There have been no longitudinal surveys on the changes in 25-hydroxyvitamin D [25(OH)D] while considering hemodilution factors among pregnant Japanese women. Therefore, we examined 25(OH)D levels as well as red blood cell count (RBC), hemoglobin (Hb), and Hematocrit (Hct) at the three trimesters among pregnant Japanese women to determine the distribution of serum 25(OH)D levels and the influence of hemodilution.

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Section: Introductionmentioning

confidence: 99%

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Takaoka¹,

Nishida²,

Sairenchi³

et al. 2020

PLoS ONE

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“…This study confirmed the results of two studies conducted in Japan which suggested that the prevalence of vitamin D deficiency was high. [10][11][12][13][14][15][16][17] To the best of our knowledge, this study is the first large sample size study which investigated vitamin D levels during pregnancy throughout 1 year in Japan, specifically looking into the effectiveness of the antenatal health guidance intervention for vitamin D insufficiency level to the pregnant women.…”

Section: Discussionmentioning

confidence: 99%

“…Maternal vitamin D deficiency has been linked with multiple adverse maternal and neonatal outcomes, such as hypertensive disorder of pregnancy, 3,4 gestational diabetes, 5,6 preterm birth, 7 and small gestational age of the infants 8,9 . Vitamin D deficiency in pregnant women is a global problem, and a Japanese survey also reported that the proportion of vitamin D deficiency is high in Japanese pregnant females 10–17 . Some countries recommend the use of vitamin D supplements, 18,19 but it is not recommended in Japan, and no guidelines for the screening and supplementation of vitamin D during pregnancy are there.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 Vitamin D deficiency in pregnant women is a global problem, and a Japanese survey also reported that the proportion of vitamin D deficiency is high in Japanese pregnant females. [10][11][12][13][14][15][16][17] Some countries recommend the use of vitamin D supplements, 18,19 but it is not recommended in Japan, and no guidelines for the screening and supplementation of vitamin D during pregnancy are there. Moreover, sufficient evidences indicating the benefits and harms of using vitamin D supplementation during pregnancy for improving maternal and infant health outcomes are limited.…”

Section: Introductionmentioning

confidence: 99%

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Ineffectiveness of antenatal guidance intervention for vitamin D insufficiency and deficiency in pregnant women in Kyoto, Japan

Yamade¹,

Inoue²,

Hamada³

et al. 2021

J of Obstet and Gynaecol

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Aim: The aim of this study was to investigate the vitamin D status among healthy pregnant women in Japan, and to evaluate the effectiveness of the antenatal health guidance intervention for the pregnant women who were informed about their low vitamin D levels. Methods: We measured the level of 25-hydroxyvitamin D (25[OH]D) using chemiluminescent immunoassay among the singleton pregnant women who received at antenatal routine check-up (8-24 weeks of gestation) with written consent during September 2017-September 2018. The measurement values were informed by the concerned physician and health guidance intervention was given to the pregnant women with inadequate Vitamin D status (25[OH]D < 30 ng/mL). At around 36 weeks of gestation, the measurement of 25(OH)D and a questionnaire regarding behavioral changes after the guidance was conducted. Results: The average value of 25(OH)D of 1192 pregnant women before the guidance was 14.89 AE 4.85 ng/mL, and the prevalence of sufficient vitamin D status (25(OH)D ≥ 30 ng/mL) was 0.67% (8/1192). Nine hundred eighty-two pregnant women who had inadequate vitamin D status were followed, thereafter-guidance prevalence of sufficiency was 1.02% (10/982); insufficiency, 14.66% (144/982); and deficiency, 84.32% (828/982), respectively. Although the prevalence of deficiency was decreased after guidance intervention significantly, the prevalence was still high and the effect on behavioral changes was a little. Conclusion:The prevalence of vitamin D sufficient status among pregnant women in Japan was extremely low, which is a serious condition. It was also revealed the effectiveness of the antenatal health guidance intervention for pregnant women was not enough.

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“…Vitamin D is a fat-soluble vitamin essential for the absorption of calcium from the intestine, thus playing an important role in the musculoskeletal function (10). Vitamin D deficiency during pregnancy is associated with an increased risk of developing maternal gestational diabetes, preeclampsia, recurrent abortions, as well as low birth weight (LBW), and intrauterine growth restriction (IUGR) of the fetus (1,6), which can lead to preterm delivery (11). Vitamin D deficiency is common in premature neonates (12).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Serum Vitamin D in the Umbilical Cord of Survived with Not Survived Premature Infants

et al. 2019

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Background: Vitamin D deficiency is associated with prematurity, respiratory problems and infections. These are important causes of death in premature neonates. Objectives: The aim of this study was to compare the vitamin D level in the blood of preterm live neonates discharged with those neonates who did not survive. Methods: In a cross-sectional study, 335 premature infants (less than 34 weeks of gestation) were discharged and 48 infants died. We examined their umbilical cord blood for vitamin D. Results: Eighty-eight percent of our premature neonates had vitamin D deficiency. The mean of vitamin D in the survived neonates was 14.87 ± 10.94 and in those who succumbed their prematurity it was 9.4 ± 6.52 ng/mL (P < 0.01). There was a significant difference between the two groups in terms of the type of delivery, Apgar score of first and fifth minutes, duration of oxygen therapy and gestational age (P < 0.05). Conclusions: The results of this study showed that most premature neonates have a severe vitamin D deficiency, and this deficiency was more pronounced in the dead neonates than in those that survived, despite eliminated the role of gestational age. Measurement of cord blood vitamin D level may help predict the prognosis for premature neonates.

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Effect of prolonged hospitalization for threatened preterm labor on maternal and fetal vitamin D levels

Abstract: Prolonged hospitalization for TPL reduced the maternal vitamin D status but did not influence the neonatal status at delivery.

Cited by 8 publications

References 29 publications

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Ineffectiveness of antenatal guidance intervention for vitamin D insufficiency and deficiency in pregnant women in Kyoto, Japan

Comparison of Serum Vitamin D in the Umbilical Cord of Survived with Not Survived Premature Infants

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