Effect of Prolonged Treatment with Human Chorionic Gonadotropin on the Endogenous Steroid Hormone Metabolism of Physically and Mentally Retarded Boys

Reiß, M.; Hillman, Janet; Rm, Davis

doi:10.1210/jcem-23-1-11

Cited by 6 publications

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“…Urinary 17-ketosteroids were extracted from one of the pooled urine specimens of each patient after hot acid hydrolysis and gradient elution chromatography carried out according to Kellie & Wade (1957) with such modifications as used by us before (Reiss, Hillman & Davis, 1963). Urinary total 17-hydroxycorticosteroids (17-OHCS) were determined by Norymberski's technique (Appleby, Gibson, Norymberski & Stubbs, 1955).…”

Section: Methodsmentioning

confidence: 99%

Interrelation Between Human Chorionic Gonadotrophin Inhibitory Activity in Plasma and Urine and the Rate of Urinary Gonadotrophin Excretion

Yamashita¹,

Hillman²,

Reiß³

1965

Journal of Endocrinology

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The interrelation of urinary and plasma human chorionic gonadotrophin (HCG) inhibitors and the urinary excretion rate of gonadotrophin was studied in ten physically and mentally retarded young males.It was found that the HCG-inhibitory principles had no effect when assayed against the boys' own urinary gonadotrophins.The excretion rate of urinary gonadotrophin was found to be independent of the presence of urinary or plasma HCG-inhibitors, which in turn were not related to the boys' physical development.Certain similarities between the properties of the plasma and urinary HCG-inhibitor and deproteinized pineal extracts are discussed.

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Section: Methodsmentioning

confidence: 99%

Interrelation Between Human Chorionic Gonadotrophin Inhibitory Activity in Plasma and Urine and the Rate of Urinary Gonadotrophin Excretion

Yamashita¹,

Hillman²,

Reiß³

1965

Journal of Endocrinology

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“…Investigations of the endocrinology of physically and mentally retarded male patients have been carried out in this laboratory for several years (Reiss, Berman, Pearse, Albert-Gasorek & Hillman, 1961;Reiss, Hillman & Davis, 1963;Pearse & Reiss, 1963;Reiss, 1963). Serum, cerebro-spinal fluid and urine have been, and are being, tested for their increased or decreased levels of various hormones and for any ability to augment or inhibit the action of the trophic hormones of the adeno¬ hypophysis.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the Biological Action of Gonadotrophin, Thyrotrophin and Corticotrophin by Small Amounts of Serum and Cerebro-Spinal Fluid

Reiß¹,

Pearse²,

Rm³

et al. 1964

Journal of Endocrinology

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The action of human chorionic gonadotrophin on mice was inhibited by small amounts of serum (1\m=.\8c.c.) and cerebro-spinal fluid (0\m=.\6ml.) from thirty-one out of forty-two mentally and physically retarded male patients aged 8\p=n-\16 yr. Serum from some of these patients also inhibited the action of thyrotrophic hormone in mice and of corticotrophin in rats. Small (1\m=.\8ml.) amounts of serum of three out of fifteen mentally normal subjects of the same age range inhibited the action of human chorionic gonadotrophin (HCG).The serum of four healthy adult men had no inhibitory activity. However, the serum of the parents of two morons, whose serum was inhibitory, also inhibited the action of HCG.The inhibition of gonadotrophic activity by the serum and cerebro-spinal fluid was similar to the action of protein-free pineal extracts.

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Labhart¹

1974

Clinical Endocrinology

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Effect of Prolonged Treatment with Human Chorionic Gonadotropin on the Endogenous Steroid Hormone Metabolism of Physically and Mentally Retarded Boys

Cited by 6 publications

References 0 publications

Interrelation Between Human Chorionic Gonadotrophin Inhibitory Activity in Plasma and Urine and the Rate of Urinary Gonadotrophin Excretion

Interrelation Between Human Chorionic Gonadotrophin Inhibitory Activity in Plasma and Urine and the Rate of Urinary Gonadotrophin Excretion

Inhibition of the Biological Action of Gonadotrophin, Thyrotrophin and Corticotrophin by Small Amounts of Serum and Cerebro-Spinal Fluid

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