Effect of prophylactic nonsteroidal antiinflammatory drugs on cystoid macular edema assessed using optical coherence tomography quantification of total macular volume after cataract surgery

Abstract

Used prophylactically after cataract surgery, ketorolac 0.5% was efficacious in decreasing postoperative macular edema.

Ketorolac therapy for the prevention of acute pseudophakic cystoid macular edema: a systematic review

“…The Almeida, Donnenfeld, and Wittpenn studies were determined to have a statistical power of 2.5%, 45.1%, and 53.1%, respectively. 9,10,12 The power of the Chatiziralli study 11 was inestimable because of the fact that there were no incidents of CME in either group.…”

“…Two RCTs used ketorolac tromethamine 0.4% whereas the other two employed ketorolac tromethamine 0.5% Two RCTs utilized placebo drops as their control group compared with the other two RCTs using only a steroid and antibiotic Variation in sample size Differences in time when ketorolac was administered (pre-, peri-, and/or postoperatively) Only one RCT analyzed contrast sensitivity 9 Two RCTs assessed CME via OCT 9,12 All but Almeida et al 12 evaluated best-corrected visual acuity.…”

“…8 More specifically, several randomized controlled clinical trials (RCTs) have revealed the potential benefit of one of these topical NSAIDs, ketorolac tromethamine (Acular LS, Allergan Inc., Irvine, CA, USA), in the management of acute pseudophakic CME. [9][10][11][12] The purpose of this systematic review is to assess the effectiveness of ketorolac vs control in the treatment of acute pseudophakic CME (necessitating therapeutic intervention within 4 months of CME onset). [13][14][15] …”

Impact of nepafenac 0.1% on macular thickness and postoperative visual acuity after cataract surgery in patients at low risk for cystoid macular oedema

“…Prospective studies evaluated the effect of a postoperative NSAID on the development of macular oedema after phacoemulsification. 7,[17][18][19] At 5 weeks after phacoemulsification, Miyake's study documented 5.7 vs 54.7% angiographic CME in the eyes that received only diclofenac 0.1% vs the eyes that received only flurometholone 0.1%, respectively. 7 Two recent studies confirmed these findings when an NSAID was used preoperatively and postoperatively.…”

New Look at Ocular Inflammation Control – Powerful and Fast-acting Twice-daily Bromfenac for a Novel Standard in the Treatment of Inflammation

“…58 However, it was not until much later that ketorolac 0.5% and diclofenac 0.1% proved effective in treating this condition. Ketorolac 0.5% was efficacious in decreasing post-operative macular oedema when used prophylactically after cataract surgery, 59 while diclofenac 0.1% was more effective than betamethasone in preventing angiographic CME and blood-aqueous barrier disruption after small-incision cataract surgery. 60 While no randomised trials have yet been conducted to test the ability of the two new-generation topical NSAIDs -nepafenac and bromfenac -in treating CME, numerous reports suggest that these agents also have activity against this condition.…”