Effect of Propolis on Virulence Factors of<i>Candida albicans</i>

D’Auria, Felicia Diodata; Tecca, M.; Scazzocchio, F; Renzini, V.; Strippoli, V.

doi:10.1179/joc.2003.15.5.454

Cited by 38 publications

(24 citation statements)

References 20 publications

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“…Furthermore, CAPE can inhibit replication of viruses (including HIV) and bacteria [86]. Data on the antifungal activity of CAPE are limited, but propolis extracts were shown to inhibit C. albicans hyphal formation [87] and treat oral candidiasis [88]. The low toxicity and broad antifungal activity may make CAPE an important addition to the antifungal armamentarium.…”

Section: Caffeic Acid Phenethyl Ester (Cape)mentioning

confidence: 99%

Antifungal Drug Discovery through the Study of Invertebrate Model Hosts

Pukkila-Worley¹,

Holson²,

Wagner³

et al. 2009

CMC

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There is an urgent need for new antifungal agents that are both effective and non-toxic in the therapy of systemic mycoses. The model nematode Caenorhabditis elegans has been used both to elucidate evolutionarily conserved components of host-pathogen interactions and to screen large chemical libraries for novel antimicrobial compounds. Here we review the use of C. elegans models in drug discovery and discuss caffeic acid phenethyl ester, a novel antifungal agent identified using an in vivo screening system. C. elegans bioassays allow high-throughput screens of chemical libraries in vivo. This whole-animal system may enable the identification of compounds that modulate immune responses or affect fungal virulence factors that are only expressed during infection. In addition, compounds can be simultaneously screened for antifungal efficacy and toxicity, which may overcome one of the main obstacles in current antimicrobial discovery. A pilot screen for antifungal compounds using this novel C. elegans system identified 15 compounds that prolonged survival of nematodes infected with the medically important human pathogen Candida albicans. One of these compounds, caffeic acid phenethyl ester (CAPE), was an effective antifungal agent in a murine model of systemic candidiasis and had in vitro activity against several fungal species. Interestingly, CAPE is a potent immunomodulator in mammals with several distinct mechanisms of action. The identification of CAPE in a C. elegans screen supports the hypothesis that this model can identify compounds with both antifungal and host immunomodulatory activity.

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Section: Caffeic Acid Phenethyl Ester (Cape)mentioning

confidence: 99%

Antifungal Drug Discovery through the Study of Invertebrate Model Hosts

Pukkila-Worley¹,

Holson²,

Wagner³

et al. 2009

CMC

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“…An aqueous ethanol extract from green propolis collected in Minas Gerais, a state in Southeastern Brazil, was found to inhibit oral candidiasis in denture-wearing patients with both stomatitis and candidiasis (Santos et al, 2005). This product can cause dose-and time-dependent inhibition of phospho-lipase activity and damage to the plasmatic membrane structure of this fungus (D'Auria et al, 2003).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Use of phytotherapy in dentistry

Groppo

Bergamaschi

Cogo

et al. 2008

Phytotherapy Research

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Over the past decade, interest in drugs derived from medicinal plants has markedly increased. This study was aimed at a literature review focusing on studies investigating herbal drugs and other natural products, as well as their therapeutic application, side effects and possible drug interactions. Few studies were found to support their rational use in dentistry. Since there is an increasing use of phytotherapeutic agents in dentistry, further studies are needed to evaluate their safety and effectiveness for clinical use.

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“…Flavonoids, aromatic acids, diterpenic acids, and phenolic compounds appear to be the principal components responsible for the biologic activities of propolis samples. In recent years, several studies on the antibacterial activity of propolis have been done and the results have shown considerable similarity 10–17 . Although propolis samples of different origins have different compositions, they have similar antimicrobial effects 10 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay

Koc

Silici²,

Ayangil

et al. 2005

Mycoses

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The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis.

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Effect of Propolis on Virulence Factors ofCandida albicans

Cited by 38 publications

References 20 publications

Antifungal Drug Discovery through the Study of Invertebrate Model Hosts

Antifungal Drug Discovery through the Study of Invertebrate Model Hosts

Use of phytotherapy in dentistry

Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay

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