Effect of Protein Deficiency during Gestation and Lactation on Body Weight and Composition of Offspring

Venkatachalam, P. S.; Ramanathan, Krishnan

doi:10.1093/jn/84.1.38

Cited by 44 publications

(24 citation statements)

References 4 publications

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“…A 7% wheat protein diet fed during pregnancy and lactation severely affected the quantity of milk produced, but not the concentration of protein n the milk (22). Pups of mothers on 7% wheat protein diet showed 100% mortality (22). Recently, Rosso et al (23) found that 50% restriction of the normal food intake of rats during pregnancy resulted in a marked reduction in the weight of their mammary glands, with significant reductions in the DNA, RNA, and protein contents of the glands.…”

Section: Resultsmentioning

confidence: 99%

“…Protein deficiency during pregnancy and lactation may reduce the output of milk, resulting in starvation during suckling and also, the pups may not have sufficient vigor at birth to obtain adequate nourishment by suckling (18). A 7% wheat protein diet fed during pregnancy and lactation severely affected the quantity of milk produced, but not the concentration of protein n the milk (22). Pups of mothers on 7% wheat protein diet showed 100% mortality (22).…”

Section: Resultsmentioning

confidence: 99%

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Effect of protein nutrition throughout gestation and lactation on growth, morbidity and life span of rat progeny.

Sasaki¹,

Nakagawa²,

Kajimoto³

1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThirteen Fischer strain rats were divided randomly into 3 groups soon after became pregnant and fed a 10%, 18%, or 36% casein diet throughout pregnancy and lactation. At weaning, female pups from the dams were divided into 3 further groups which were fed throughout life 10%, 18%, or 36% casein diet. The animals were weighed regularly and given a full autopsy after death. DNA was determined in the cerebrum and cerebellum of progeny at 7, 15 and 50 weeks of age respectively. The level of protein intake of the dams did not affect the litter-size, but did affect the body weight of pups at weaning. When fed a high protein diet after weaning, pups from dams fed a low protein diet weighed less throughout life than those from dams fed a high protein diet. A similar effect of protein intake was observed on the tail length. Pups of dams fed a low protein diet ate a larger amount of diet per unit body weight after weaning than those of dams fed at a high level of protein. Pups at 7, 15, and 50 weeks of age respectively from dams fed 10% casein diet had a lighter cerebrum and cerebellum than pups of the same ages from dams fed respectively 18% and 36% casein diet. They also had less total DNA in the cerebrum and cerebellum than the latter. At the ages of 1 and 2 years respectively, the survival rates of rats fed the same diet as their mothers tended to be greater than those of rats fed diet different from that of their mothers. They also tended to live longer than the latter: 4 of 60 rats lived for over 1,000 days, and 3 of these were fed the same diet as that of their mothers. Lesions observed at death did not differ in different groups. However, the incidence of lesions of the kidney and the number of tumors seemed to be greater in groups fed a high protein diet.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effect of protein nutrition throughout gestation and lactation on growth, morbidity and life span of rat progeny.

Sasaki¹,

Nakagawa²,

Kajimoto³

1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…In an experiment in which the timing of the duration of the protein-free diet was varied, Nelson and Evans (1 953) found consistent reproductive failure (90-1 00%) if the proteinfree diet was started on the day of mating, but if this dietary treatment was started 7 days after mating, 90% of the litters were delivered. In a complementary study, Venkatachalam and Ramanathan (1964) found the following: Infant mortality reached 100% in the offspring of rats fed a 7% protein diet both during gestation and lactation. The mortality was 78% in the offspring of rats that were fed this diet during lactation only and in these the weaning weight was 290 ALTMAN, DAS AND SUDARSHAN lowered.…”

Section: Dietary Deprivation Before or During Gestationmentioning

confidence: 96%

The influence of nutrition on neural and behavioral development. I. Critical review of some data on the growth of the body and the brain following dietary deprivation during gestation and lactation

Altman

Das

Sudarshan

1970

Developmental Psychobiology

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Data on the Growth of the Body and the Brain FollowingDietary Deprivation during Gestation andLactation. DEVELOPMENTAL PSYCHOBIOLOGY, 3(4): 28 1-301. The scanty data available on the effects of undernutrition during gestation and lactation upon neural development in man are reviewed briefly. This review is followed by a description of the various techniques that have been employed for the experimental undernutrition of laboratory animals. Then a detailed review is given of the effects of dietary deprivation during gestation, lactation, after weaning, and in adulthood upon the development of the nervous system and its different parts in a variety of mammalian species, with special emphasis on the rat. Finally, in a programmatic statement, the developmental phases during which undernutrition can be produced experimentally are related to critical stages or vulnerable periods of brain development. undernutrition brain growth

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“…Pups born on the same day in the stock colony were pooled and assigned in litters of eight to mothers fed either the stock diet (18% protein, control) or a 6% casein diet (5% protein, undernourished). The feeding of a low-protein diet to the mothers is not found t o affect the quality of the milk but the quantity of the same is found to be markedly reduced thereby causing severe undernutrition in the pups (Muller and Cox, 1946;Venkatachalam and Ramanathan, 1964). Some of the pups from control and undernourished groups were killed at 21 days of age.…”

Section: Methodsmentioning

confidence: 99%

Effects of Nutritional Rehabilitation on the Content and Lipid Composition of Brain Gray and White Matter of Neonatally Undernourished Rats

Rajalakshmi

1982

Journal of Neurochemistry

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Effect of Protein Deficiency during Gestation and Lactation on Body Weight and Composition of Offspring

Cited by 44 publications

References 4 publications

Effect of protein nutrition throughout gestation and lactation on growth, morbidity and life span of rat progeny.

Effect of protein nutrition throughout gestation and lactation on growth, morbidity and life span of rat progeny.

The influence of nutrition on neural and behavioral development. I. Critical review of some data on the growth of the body and the brain following dietary deprivation during gestation and lactation

Effects of Nutritional Rehabilitation on the Content and Lipid Composition of Brain Gray and White Matter of Neonatally Undernourished Rats

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