Effect of Prunella vulgaris polysaccharides on cultured orbit fibroblasts in vitro from patients with thyroid-associated ophthalmopathy

Li, Bei; Guo, Jianbin; Wang, Fang; Cheng, Shuanghua; Zeng, Liuzhi

doi:10.1016/j.exer.2020.108276

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…Ursolic acid and rutin have been demonstrated to promote apoptosis and regulate immune systems in cell and animal models ( Manzoni et al, 2019 ; Satari et al, 2019 ; Zhang et al, 2020a ; Lin et al, 2020 ). Moreover, our research demonstrated that P. vulgaris polysaccharides, a main component of P. vulgaris , exert their therapeutic effect on the OFs from GO patients by inhibiting the proliferation and promoting the apoptosis of OFs ( Li et al, 2020a ).…”

Section: Tcm and Other Treatmentsmentioning

confidence: 89%

Current and promising therapies based on the pathogenesis of Graves’ ophthalmopathy

Zhang,

Zhao,

2023

Front. Pharmacol.

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Graves’ ophthalmopathy (GO) is a hyperthyroidism-related and immune-mediated disease that poses a significant threat to human health. The pathogenesis of GO primarily involves T cells, B cells, and fibroblasts, suggesting a pivotal role for the thyrotropin-antibody-immunocyte-fibroblast axis. Traditional treatment approaches for Graves’ disease (GD) or GO encompass antithyroid drugs (ATDs), radioactive iodine, and beta-blockers. However, despite decades of treatment, there has been limited improvement in the global incidence of GO. In recent years, promising therapies, including immunotherapy, have emerged as leading contenders, demonstrating substantial benefits in clinical trials by inhibiting the activation of immune cells like Th1 and B cells. Furthermore, the impact of diet, gut microbiota, and metabolites on GO regulation has been recognized, suggesting the potential of non-pharmaceutical interventions. Moreover, as traditional Chinese medicine (TCM) components have been extensively explored and have shown effective results in treating autoimmune diseases, remarkable progress has been achieved in managing GO with TCM. In this review, we elucidate the pathogenesis of GO, summarize current and prospective therapies for GO, and delve into the mechanisms and prospects of TCM in its treatment.

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Section: Tcm and Other Treatmentsmentioning

confidence: 89%

Current and promising therapies based on the pathogenesis of Graves’ ophthalmopathy

Zhang,

Zhao,

2023

Front. Pharmacol.

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“…This suggests that leptin regulates T-cell activity by interacting with DCs. However, this research used high levels of leptin stimulation on DC cells, and the function of DC cells was determined by the mice strains used [ 80 , 81 ]. Studies where leptin directly influences T-cells have reported thatLepR deficiency in CD4 + T cells impair their capacity to develop towards the Th17 phenotype through stimulation of the JAK/STAT-3 signaling pathway and its downstream targets [ 82 ].…”

Section: Leptin Receptor (Full-length Isoform Ob-rb)mentioning

confidence: 99%

Roles of four targets in the pathogenesis of graves' orbitopathy

Ren,

Zhang,

et al. 2023

Heliyon

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“…Prunella vulgaris polysaccharides in combination with dexamethasone in all concentrations can significantly promote apoptosis of orbital fibroblasts when co-cultured with IFN-γ ( p < 0.05). Our study results suggest that PV has a therapeutic effect by inhibiting the orbital fibroblast proliferation and promoting apoptosis of orbital fibroblasts among the TAO patients [ 79 ].…”

Section: Biological Activities Of Pv Extractsmentioning

confidence: 99%

Prunella vulgaris L.: An Updated Overview of Botany, Chemical Composition, Extraction Methods, and Biological Activities

et al. 2023

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Prunella vulgaris L. (PV) is a well-known renewable drug resource full of different groups of biologically active substances with a wide range of pharmacological actions and applications in medicine. In this review, we present an updated comprehensive overview of the botany, extracting methods, chemical composition, and pharmacological activity of different parts of PV extracts. As a result of this review, it was found that chemical composition of PV depends on various factors ranging from the part of the plant to the method of extraction. We also highlight extraction methods that have not been previously used for obtaining PV extracts and may have high scientific interest. With this review, we hope to guide present and future professionals and provide possible previously unexplored areas to find new solutions associated with PV plant.

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Effect of Prunella vulgaris polysaccharides on cultured orbit fibroblasts in vitro from patients with thyroid-associated ophthalmopathy

Cited by 8 publications

References 14 publications

Current and promising therapies based on the pathogenesis of Graves’ ophthalmopathy

Current and promising therapies based on the pathogenesis of Graves’ ophthalmopathy

Roles of four targets in the pathogenesis of graves' orbitopathy

Prunella vulgaris L.: An Updated Overview of Botany, Chemical Composition, Extraction Methods, and Biological Activities

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