Effect of Prunus Dulcis Extract against Total Cholesterol Level in Mice that Given Monosodium Glutamate

Abstract

Abstract. Monosodium glutamate (MSG) is chemical compound that when it is used excessively it can cause various side effects such as hypercholesterolemia. Hypercholesterolemia will result in coronary heart disease (CHD), which is a disease causing death. The aim of study was assessing the effect of almond nut/ Prunus dulcis extract against total cholesterol level in mice that given MSG. This study was randomized post test controlled group design. The sample consisted of 30 mice (Mus musculus L. Strain DDW) that were divided into three groups: control group, treatment group 1 and treatment group 2. The plasma total cholesterol of mice was measured by the method of CHOD with spectrophotometer whose wave length 500nm. Data obtained was analysed by SPSS program version 16. The mean total cholesterol level in mice that treated with Prunus dulcis extraction after 4 weeks experiment was 130.37mg/dl. It were highest compared to the other groups. One way anova showed the significance value was p=0.44), means, there was no difference of total cholesterol level between control and treatment groups 1 and 2. There was no effect of Prunus dulcis extract against total cholesterol level in mice that given monosodium glutamate.

Effect of monosodium glutamate on striato-hippocampal acetylcholinesterase level in the brain of male Wistar albino rats and its implications on learning and memory during aging

“…Neonatal administration of MSG produces hypothalamus induced obesity (Braga et al, 2001). Another study showed that 4 g MSG treated group has an increase in the body weight, but mild doses did not show any increase in the body weight (Sari et al, 2018).…”

“…Neonatal administration leads to immature blood brain barrier (Boonnate et al, 2015), degenerative changes in hypothalamic arcuate nucleus (Holzwarth-Mcbride et al, 1976), reduced serotonin and cognitive functioning (Moneim et al, 2018), pyknotic Purkinje and granule cells with infl amed cells in the cerebellum (Hashem et al, 2012). Another study showed that 4 g MSG treated group had an increase in the body weight, but mild doses did not show any increase in the body weight (Sari et al, 2018).…”

Histopathological Liver Tissues of Alloxan-Induced Wistar Rats That Given Lawsonia Inermis (Linn.) Leaves’ Ethanolic Extract

“…The treatment by utilizing natural resources such as herb plants has become a tradition of people around the world. Traditional medicine comes from the herb plant that has safe side effect compared to the chemical medicine [13,14]. There have been many studies conducted in conjunction with the treatment of DM, one of them with the utilization of herb plants.…”