Effect of PSCA gene polymorphisms on gastric cancer risk and survival prediction: A meta-analysis

Abstract

Abstract. Previous studies have shown that two single-nucleotide polymorphisms (SNPs) in PSCA (rs2976392 and rs2294008) are associated with gastric cancer (GC), but the results are conflicting. Additionally, the prognostic value of PSCA gene polymorphisms for GC patients is unknown. We performed a meta-analysis using 9 eligible case-control studies to investigate the association between PSCA polymorphisms and GC risk, and additionally investigated the prognostic value of PSCA polymorphisms for GC patients with two eligible studies. The association was measured using random-effect or fixed-effect odds ratios (ORs) combined with 95% confidence intervals (CIs) according to the heterogeneity of the studies. We found that rs2294008 (dominant model: OR, 1.44; 95% CI, 1.16-1.79) and rs2976392 (dominant model: OR, 1.41; 95% CI, 0.98-2.04) polymorphisms were associated with increased risk of GC, although the association of rs2976392 was not statistically significant. For rs2294008, the associations were all consistently significant among the different subgroups stratified by ethnicity and tumor location, but not significant in intestinal or diffuse subtypes. For rs2976392, the associations were consistently significant for the intestinal, diffuse and non-cardia subtypes, but not significant for the cardia subtype. Furthermore, two eligible studies reported inverse results of PCSA in predicting the survival of GC patients (HR, 0.75; 95% CI, and HR, 2.12; 95% CI, respectively). In conclusion, PSCA gene polymorphisms are associated with increased risk of GC and are correlated with the prognosis of GC patients. Future studies are required to evaluate the molecular mechanisms of PSCA polymorphisms in GC and validate the prognostic value in a larger number of patients.

Genetic Variation in PSCA and Risk of Gastric Advanced Preneoplastic Lesions and Cancer in Relation to Helicobacter pylori Infection

“…Consistently with studies in Europeans and meta-analyses of studies in Asians [5], [11], [29], [30], we observe an association of this SNP with all histological types of GC, without any statistically significant evidence for difference in risk between GC subtypes according to histology or location. It should be noticed however that the sample size of the subgroups in this study is rather small.…”

“…Several case-control studies confirmed the association of this SNP with GC in Asian and Caucasian populations. Meta-analyses [10], [11], [29], [30] showed ORs ranging between 1.41–1.66 for the dominant model and between 1.14–1.33 for the recessive model. The two other PSCA SNPs of our study were previously found to be associated with GC risk in Europeans [6].…”

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

“…Qiao et al [44] included eight studies from seven publications with a total of 9738 gastric cancer cases and 7054 controls, and concluded that rs2294008 T allele and rs2976392 A allele were significantly associated with increased gastric cancer risk. These findings were confirmed by other meta-analysis [45-48]. The most recent meta-analysis by Gu et al [49] involved 16 studies.…”

Associations of Genetic Variants in the PSCA, MUC1 and PLCE1 Genes with Stomach Cancer Susceptibility in a Chinese Population

“…Qiao et al [ 42 ] included eight case-control studies from seven articles and found that rs2294008 T allele and rs2976392 A allele were significantly associated with increased gastric cancer risk. These findings were also confirmed by other meta-analysis [ 43 – 46 ]. More recently, to access the contributions of these two widely investigated PSCA SNPs to gastric cancer susceptibility, Gu et al [ 47 ] performed a meta-analysis of 16 studies with a total of 18,820 cases and 35,756 controls.…”