Effect of Pulsed Radio Frequency Stimulation on Wound Healing: A Double-Blind Pilot Clinical Study

Meta-Analysis of Clinical Efficacy of Pulsed Radio Frequency Energy Treatment

“…A total of 5 randomized, controlled studies reported WH outcomes with a total of 147 patients actively treated with PRFE and 156 patients in the control group. [26][27][28][29][30] Of the 5 randomized studies, 4 were blinded studies and all were included in the P-value combination analysis. Table 4 outlines the reported information by article for the study design, number of patients enrolled, clinical area, duration of symptoms, minutes of therapy, vote, and study finding with the associated P value that was used in the combination analysis.…”

Radiofrequency-based treatment in therapy-related clinical practice – a narrative review. Part II: chronic conditions

“…Out of the 16 studies identified in this category, 14 studies (88%) investigated the effects of RF on chronic wounds or chronic ulcers, [110][111][112][113][114][115][116][117][118][119][120][121][122][123] and two on bone healing. 40,124 As identified, all studies employed devices delivering RF energy in pulsed mode at the base shortwave frequency of 27.12 MHz (PSWT).…”

“…Nine of these studies were case studies, [115][116][117][118][119][120][121][122][123] one was a cohort study 110 and a further four were clinical trials. [111][112][113][114] The case studies reported the effectiveness of PSWT treatment of diabetic foot ulcers, 115,119,123 chronic pressure ulcers, 116,122 chronic lower extremity wounds, 117,120 and venous/microvascular stasis ulcers. 118,121 In a cohort of 22 patients with pressure ulcers, Itoh and colleagues 110 In contrast, Salzberg and colleagues 112 and Kloth and colleagues 114 employed improved methods in their studies although the latter had a fairly small sample.…”

Electromagnetic Biostimulation of Living Cultures for Biotechnology, Biofuel and Bioenergy Applications

“…Influence Application Reference PEMF Chronic wound healing, and non-union fracture healing [172] Chronic wound healing [173] Treatment of osteonecrosis [174] Treatment of pressure ulcers in spinal-cord injuries [175] Treatment of osteoarthritis of the knee [176] Treatment of grade I & II ankle sprains [177] Treatment of venous leg ulceration [178] Agricultural Influence Application Reference SMF Treated water to stimulate germination in Pinus tropicalis seeds [179] Treated chickpea seeds increased germination, seedling and root length & size [180] Treated water increased plant height, branch number, and shoot dry weight [181] Treated wheat seeds increased germination, yields, and protein [182] Treated rice seeds and water increased rate and % of germination [183] Treated barley seeds and water increased length and weight [184] OMF Treated tomato seeds for increased growth, yields, and disease resistance [185] The electric field pulses, or electroporation, have been traditionally implemented in metabolic engineering for gene transformation. Direct electroporation of a cyanobacterium Synechococcus elongates, introduced the enzyme Clostridial hydrogenase, which may lead to the development of a variety of hydrogenases for hydrogen production, coupled to photosynthesis in cyanobacteria for bioenergy production [186].…”