Effect of PUVA Radiation on Anaphylactic Histamine Release from Rat Dermal Tissues

Tanii, Tsukasa; Kohno, Takeya; Mizuno, Nobuyuki; Furukawa, Masumi; Nagahama, K; Someda, Yukiko; Hamada, Takeshi; Morisaki, Noboru; Shibata, Teppei; Okada, T

doi:10.1159/000248469

Cited by 1 publication

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“…Female SKH/hrl hairless mice aged 7 to 10 weeks, obtained from Charles River Breeding Laboratories (Wilmington, MA, USA), were used. IN-B irradiation or PlNA treatment were performed as described previously (8)(9)(10)(11)20). In brief, IN-B irradiation (50 mJ/cm 2 ) was administered to n rf- ksay of ODe activity Mice were sacrificed at indicated times.…”

Section: Treatment Of Micementioning

confidence: 99%

Effects of Ultraviolet‐B and PUVA on Ornithine Decarboxylase Activity, DNA Synthesis, and Protein Kinase C Activity in Mouse Skin

Mizuno

Kono

Taniguchi

et al. 1993

The Journal of Dermatology

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Ultraviolet-B and PUVA share several biological events with phorbol ester tumor promoters. The effects of ultraviolet-B irradiation and topical PUVA treatment on ornithine decarboxylase activity, DNA synthesis, and protein kinase C activity, which are known to be induced or activated by phorbol ester tumor promoter, were investigated in hairless mouse skin. Ornithine decarboxylase activity was remarkably enhanced by ultraviolet-B and PUVA. Although PUVA did not affect DNA synthesis significantly, ultraviolet-B stimulated epidermal DNA synthesis approximately 5-fold over control values at 48 h. However, unexpectedly, neither cytosolic nor membrane-bound protein kinase C activity showed any change during the 2 h after either treatment. These results suggest that the protein kinase C system is not involved in the initial signal transduction system of ultraviolet-B or PUVA, unlike the case with phorbol ester tumor promoter.

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Section: Treatment Of Micementioning

confidence: 99%