Effect of Pyridoxine Deficiency on Cholcsterol and Polyenoic Fatty Acids in Chicks

Abstract

Summary. The influence of pyridoxine deficiency on chicks fed fat‐free and 10% peanut oil‐diets with and without 1 % cholesterol was studied. Cholesterol: The pyridoxine‐deficient diets caused significantly higher plasma cholesterol than the diets with added pyridoxine. The aorta vliolcsterol showed changes in the same direction. Liver chiolesterol was not, significantly affectd. The pyridoxine‐deficient diets caused lower cholesterol content in the heart than did the supplemented diets. Polyevie fatty acids: With a fat‐free, pyrudixine‐deficient diet a marked content of tetraenoic acid was found in heart and liver, whereas the tritenoic acid was proportionally decreased. Feeding of 10% peanut oil without pyridoxine caused less deposition of tetraenoic in heart and especially in the liver than feeding of 10 % peanut oil with pyridoxine. Addition of 1% cholesterol to the diets resulted in a decrease in the amount of tetraenoic acid in heart and liver.

Vitamin B6 and Cholesterol Metabolism in the Chick

“…Simple correlation coefficient for liver lipids versus liver cholesterol is given in Table 6. Several reports have appeared to date in support of this finding in work with monkeys (Greenberg and Rinehart, 1951), dogs (Mushett and Emerson, 1956), chicks (Dam et al 1958), and rats (Goswami and Sahu, 1961). The exact nature of this interrelationship is not yet understood.…”

A Combination of Zinc and Pyridoxine Supplementation to the Diet of Laying Hens Improves Performance and Egg Quality

“…Effects of pyridoxine (deficiency or supplements) on blood lipid parameters are not consistent in the literature. Many researchers [46][47][48] reported that serum cholesterol was elevated in chicks fed vitamin B-6-deficient diets. Similarly, Harripersad and Burger [49] reported lower total cholesterol concentrations in Wistar rats fed 60 μg pyridoxine/day (normal dose) compared with that of rats fed 20 μg pyridoxine/day (deficient dose).…”

Influence of vitamin B6 deficiency on selected aspects of metabolism in the chick

“…They sug gested that the hypercholesterolemia is probably due to in creased mobilization of cholesterol from the liver. Dam et al (1958) studied the effect of vitamin B A de-1 " 0 ficiency on cholesterol content of plasma, liver, heart and aorta of chicks fed fat-free diets or diets containing 10 per cent peanut oil, with or without one percent dietary choles terol. Plasma cholesterol was significantly higher in the chicks fed vitamin B^-deficient diets than in chicks receiving diets with added pyridoxine.…”