Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats

Morales, Ana Isabel; Vicente-Sánchez, C.; Jerkić, Mirjana; Santiago, José M.; Sánchez-González, Penélope; Pérez‐Barriocanal, Fernando; López‐Novoa, José M.

doi:10.1016/j.taap.2005.09.006

Cited by 115 publications

(83 citation statements)

References 46 publications

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“…Chronic administration of Cd to rats was associated with increased MT expression in kidney, and administration of quercetin had a marked protective effect on Cd-induced nephrotoxicity (Morales et al, 2006a). However, the present result showed no significant change of MT content after co-treatment with CAPE.…”

Section: Discussioncontrasting

confidence: 76%

Protective effect of caffeic acid phenethyl ester against cadmium-induced renal damage in mice

Gong

Chen

et al. 2012

J. Toxicol. Sci.

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-Cadmium (Cd) is classified as an environmental pollutant and human carcinogen. Caffeic acid phenethyl ester (CAPE), a biological active component of honeybee propolis extracts, has been used as a folk medicine with no harmful effects on normal cells. Here we investigated the beneficial effect of CAPE on Cd-induced renal damage in mice. Since renal damage induced by Cd (II) is related to oxidative stress, lipid peroxidation (LPO), protein carbonyl (PCO), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were evaluated. Moreover, the concentrations of Cd and zinc (Zn) in the kidney were analyzed. The intoxication of Cd (II) leads to the enhanced production of LPO and PCO, and the decrease of SOD activity and GSH level, probably due to the serious oxidative stress. However, the activities of CAT in the Cd (II)-induced group showed an elevated tendency, probably relating to an adaptive-response to the oxidative damage. The co-administration of CAPE can attenuate the oxidative stress caused by the intoxication of Cd and restore the altered antioxidant defense system. Based on our data, it is proposed that CAPE may involve in the protection of renal damage induced by Cd (II) owing to its antioxidant capacity and anti-inflammatory effect.

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Section: Discussioncontrasting

confidence: 76%

Protective effect of caffeic acid phenethyl ester against cadmium-induced renal damage in mice

Gong

Chen

et al. 2012

J. Toxicol. Sci.

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“…Renal I/R activates NOS and increases the expression of NOS proteins (22,23). In spite of all the studies carried out, the role of NO in I/R remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Effects of quercetin on apoptosis, NF-κB and NOS gene expression in renal ischemia/reperfusion injury

Kinaci

Erkasap

Küçük

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to investigate the effects of quercetin on nitric oxide synthase (NOS), nuclear factor-κB (NF-κB) and apoptosis in renal ischemia/reperfusion (I/R) injury in rats. A total of 42 Sprague-Dawley rats were divided into three groups. The control, I/R and I/R+quercetin (I/R+Q) groups were treated with quercetin (50 mg/kg intraperitoneal) 1 h prior to the induction of ischemia. Tissue malondialdehyde (MDA) and glutathione (GSH) levels were determined by high-performance liquid chromatography (HPLC). p53, endothelial NOS (eNOS) and NF-κB expression were assessed immunohistochemically, and apoptosis assesment was performed using terminal deoxy nucleotidyl transferase dUTP nick end-labeling (TUNEL) assay. The mRNA levels of inducible NOS (iNOS) in renal tissue were determined by realtime polymerase chain reaction (RT-PCR). MDA levels were significantly decreased in the quercetin group compared to the I/R group. However, GSH levels were significantly increased with quercetin treatment in the I/R group. Histological results, the number of apoptotic and p53-positive cells, NF-κB and eNOS expression levels were significantly decreased in the quercetin treatment group compared to the I/R group. iNOS gene expression increased in the I/R group, but no significant difference was found between the I/R and quercetin treatment groups. Therefore, quercetin not only has antioxidant and antiapoptotic activities, but also has an inhibitory effect on eNOS and NF-κB for renal tissue protection during I/R injury in rats. Therefore, quercetin may be a promising renoprotective therapeutic agent.

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“…Quercetin inhibits oxidative stress and increased gene expression of antioxidant enzymes in rotenone-exposed rats [17]. A d m i n i s t r a t i o n o f q u e r c e t i n i n c r e a s e d metallothionein expression and prevented cadmium-induced nephrotoxicity by inhibiting cadmium-induced overexpression of inducible nitric oxide synthase and cyclooxygenase-2 in Wistar rats [18]. Consequently, our results were similar to those of in vitro and in vivo studies, suggesting quercetin attenuated the oxidative damage caused by oxidative chemicals.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Protects Spermatogonial Cells from 2,4-D-Induced Oxidative Damage in Embryonic Chickens

Zhang

Taya

2007

J. Reprod. Dev.

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Abstract. Quercetin, an antioxidant flavonoid, is considered beneficial to human and animal health. In this study, the protective effects of quercetin in relation to oxidative damage of testicular cells were studied by analysis of the intracellular antioxidant system after treatment of embryonic chickens with hypoxanthine-xanthine oxidase (HX-XO) or 2,4-dichlorophenoxyacetic acid (2,4-D). Testicular cells from Day 18 embryos were challenged with quercetin alone or in combinations with HX-XO or 2,4-D for 48 h in culture. The results showed that quercetin manifested no deleterious effects on spermatogonial cells at concentrations up to 1.0 µg/ml. Exposure to HX-XO or 2,4-D (50 µg/ml) induced condensed nuclei and vacuolated cytoplasm and a decrease in testicular cell viability and spermatogonial cell number. Membrane integrity was damaged by elevated lactate dehydrogenase leakage. Exposure to HX-XO or 2,4-D also elicited lipid peroxidation by elevation of thiobarbituric acid reactive substances and decreased glutathione content and superoxide dismutase activity. However, simultaneous supplementation with quercetin restored these parameters to the levels in the controls. Consequently, HX-XO and 2,4-D induced oxidative stress in spermatogonial cells; however, dietary quercetin may attenuate the negative effects of environmental toxicants and restore the antioxidant system in testicular cells.

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Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats

Cited by 115 publications

References 46 publications

Protective effect of caffeic acid phenethyl ester against cadmium-induced renal damage in mice

Protective effect of caffeic acid phenethyl ester against cadmium-induced renal damage in mice

Effects of quercetin on apoptosis, NF-κB and NOS gene expression in renal ischemia/reperfusion injury

Quercetin Protects Spermatogonial Cells from 2,4-D-Induced Oxidative Damage in Embryonic Chickens

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