Effect of quinoa (Chenopodium quinoa) on Lipid Profile in Rats Exposed to twoSynthetic Food colors

Abstract

Increasing scientific evidence suggests potential adverse effects on children's health from synthetic chemicals used as food additives. Synthetic food colors are food additives are widely used as colorants in food. This study was conducted to investigate the effectiveness of quinoa powder as nutraceuticals on lipids profile for young experimental rats exposed to chronic administration of synthetic food colores (azo dyes),chocolate brown (CH) or sunset yellow (SY). Seventy healthy young male albino rats "Sprague Dawley" strain weighing (90 ± 10g), were used and divided randomly into two main groups; the first main group (n=10 rats) was kept as (-ve) control group and fed on basal diet. The second main group (n =60 rats) were divided into 6 sub-groups (equal groups) and fed on basal diet as follow: The first three subgroups were fed on chocolate brown oral dose (0.3 mg/kg b.wt.) one was kept as a (+ve) control group, while the other two subgroups were fed on quinoa as powder mixed with the basal diet (5%, 10% respectively) as replacement from starch. The other three subgroups were fed on SY oral dose (2.5 mg/kg b.wt.) one was kept as a(+ve) control group, while the other two subgroups were fed quinoa as powder mixed with the basal diet (5%,10%respectively) as replacement from starch. At the end of the experiment (56 days), feed intake (FI), body weight gains (BWG%), feed efficiency ratio (FER)were finally calculated. Rats were sacrificed and relative weights of livers, kidneys, hearts, spleens were calculated, blood samples were collected for biochemical analysis: T.C, T.G, LDL-C,VLDL-C and HDL-C. Moreover, histopathological changes of hearts were examined. The results indicated that chronic administration of synthetic food colors CH or SY recorded significant changes for all above biochemical parameters. While the treatment with quinoa powder revealed significant improvement in all of them. Histopathological examination supported these findings. It could be concluded that quinoa was effective in treatment dysfunction induced by azo dyes. This effect may be due to high content of phenolic compounds in quinoa. Key wards:azo dyes, chocolate brown, sunset yellow, quinoa, lipids profile.

Ameliorative effect of herbal extracts on lipid profile in albino rats, Rattus norvegicus exposed to metanil yellow

“…Altered lipid profile in blood serum observed in rats fed with common azo dye during this study also agree with other studies (Saxena and Sharma, 2015;El-Desoky et al, 2017;Reza et al,2019). Sharma et al (2009) and Bahnasy and Ragheb (2020) reported changes in lipid profile of rats fed with other food colours also viz., sunset yellow and chocolate brown. Significantly greater concentration of TC and TG has also been reported in rats when administered to fast green orally (Turley 2004;Ashour and Abdelaz, 2009).…”

“…Other researchers also studied that plant extracts could be effective means for reducing toxicity caused by food colours. Bahnasy and Ragheb (2020) studied ameliorative effect of Chenopodium quinoa for toxicity caused by chocolate brown and sunset yellow and observed significant decrease in TC, TG and LDL and significant increase in HDL treated with its extract along with food colour. Yanam et al, (2020) also reported that quinoa could ameliorate the hyperlipidaemic condition induced by high fat diet.…”