Effect of ractopamine on whole body and splanchnic energy metabolism in Holstein steers

Koontz, A. F.; El‐Kadi, Samer W.; Harmon, D. L.; Vanzant, E.S.; Matthews, J. C.; Boling, J. A.; McLeod, K. R.

doi:10.4141/cjas09078

Cited by 12 publications

(4 citation statements)

References 29 publications

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“…In the present study, urine output was lesser in steers receiving ractopamine HCl, contributing to the lesser overall N excretion by ractopamine HCl-fed steers. It is unclear if others have noted similar effects of ractopamine HCl supplementation, as no studies completed with cattle supplemented ractopamine HCl report total urine output (Abney et al, 2007;Walker et al, 2007;Koontz et al, 2010). However, research in swine suggests a decrease in urine output can occur with ractopamine HCl supplementation (Ross et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Supplemental Zinc and Ractopamine Hydrochloride on Trace Mineral and Nitrogen Retention of Beef Steers

Carmichael

Genther-Schroeder

Blank

et al. 2018

Journal of Animal Science

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The study objective was to determine whether N retention was improved with supplemental Zn above NRC concentrations with or without ractopamine hydrochloride inclusion. Angus crossbred steers (n = 32, 485 ± 26 kg BW) with Genemax gain scores of 4 or 5 were utilized in a 2 × 2 factorial arrangement (8 steers/treatment). Steers were blocked by BW to a finishing diet with 1 of 2 mineral supplementation strategies (ZNTRT), no supplemental Zn (analyzed 32 mg Zn/kg DM; CON) or supranutritional Zn (CON + 60 ppm ZnSO4 + 60 ppm Zn-amino acid complex; analyzed 145 mg Zn/kg DM; SUPZN), fed 56 days in pens equipped with GrowSafe bunks and assigned to β-agonist (BA) supplementation strategies of 0 (NON) or 300 mg steer-1 d-1 ractopamine hydrochloride (RAC) fed the last 30 d before harvest. Initial 56-d ADG was not affected by ZNTRT (P = 0.66), but DMI was greater in CON vs. SUPZN (P < 0.01). On day 56 (day 1 of BA supplementation), steers (4 groups; 8 steers/group; 2 steers/treatment) were moved to metabolism crates and adapted for 10 d, followed by 5 d of total fecal and urine collection. Total retention of Zn, Mn, Fe, Cu, and N were calculated. Data were analyzed as a 2 × 2 factorial arrangement, with group as a fixed effect and the 3-way interaction of ZNTRT × BA × group as random. No interactions between ZNTRT and BA were noted for any data (P ≥ 0.19). Collection DMI did not differ among treatments (P ≥ 0.23); however, Zn intake was lesser in CON vs. SUPZN (P < 0.01). Fecal and urinary Zn excretion and Zn and Mn retention were lesser in CON vs. SUPZN (P ≤ 0.03); however, Zn retention was not different between NON and RAC (P = 0.43). Retention of Cu and Fe was unaffected by strategies (P ≥ 0.49). Urine output and urine N excretion were greater in NON vs. RAC (P ≤ 0.05). Nitrogen retention (as percent of N intake) was lesser (P = 0.05) in CON (40.0%) vs. SUPZN (44.3%) and lesser (P = 0.02) in NON (39.5%) vs. RAC (44.8%). Zinc and N retention were found to be positively correlated (r = 0.46, P < 0.01). Average daily gain and G:F across the 86-d trial were lesser in NON vs. RAC (P < 0.03). Overall, SUPZN appears to improve N retention, suggesting that increasing dietary Zn may be important for cattle growth beyond that induced by ractopamine hydrochloride.

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Section: Discussionmentioning

confidence: 99%

The Influence of Supplemental Zinc and Ractopamine Hydrochloride on Trace Mineral and Nitrogen Retention of Beef Steers

Carmichael

Genther-Schroeder

Blank

et al. 2018

Journal of Animal Science

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“…Steers were fed treatments for 7 d in individual pens before being transferred to metabolism stalls (1.52 m × 2.13 m) for the measurement of respiratory gas exchange using indirect calorimetry. The design of the head-box-style respiration chambers was previously described by Koontz, et al [29]. Each respiration chamber was fitted with a waterer, feeder, and air-conditioning unit to maintain consistent temperature (21 • C) and relative humidity (35%).…”

Section: Respiratory Gas Exchangementioning

confidence: 99%

Influence of Anti-Coccidial Compounds and Phytogenic Saponin Extracts on In Vitro and In Vivo Ruminal Fermentation and Methane Production of Cattle

Trotta

Kreikemeier²,

Foote³

et al. 2023

Animals

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Four experiments were conducted to evaluate sources of anti-coccidial compounds and phytogenic saponin extracts on in vitro and in vivo ruminal fermentation and CH4 production at multiple inclusion levels. In experiment 1, eight steers were fed either a finishing diet or a finishing diet supplemented with 0.5 mg/kg BW decoquinate (DCQ) and 3.33 mg/kg BW Yucca schidigera extract (YSE), and respiratory gas exchange was measured. In experiment 2, four ruminally-cannulated steers were fed the same treatments as experiment 1, and ruminal fermentation was evaluated. Anti-coccidial sources (experiment 3; monensin, DCQ, amprolium) and saponin sources (experiment 4; YSE, Quillaja saponaria extract) and levels were evaluated for effects on in vitro ruminal fermentation and CH4 production. DCQ + YSE supplementation did not influence (p ≥ 0.24) in vivo respiratory gas consumption/production, in situ DM degradation, or liquid passage kinetics. Ruminal propionate proportion tended to increase (p = 0.09) with DCQ + YSE. Monensin decreased (p ≤ 0.04) in vitro acetate:propionate and CH4 production; saponin supplementation linearly increased (p < 0.01) propionate proportion but did not influence (p ≥ 0.38) in vitro CH4 production. Saponins and non-antibiotic anti-coccidials did not influence in vitro or in vivo CH4 production with finishing diets.

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“…The observed improvement in feed efficiency (G:F) with RAC supplementation was likely because of its function as a repartitioning agent ( Moloney et al, 1991 ). Koontz et al (2010) found that RAC does not change whole-body energy balance yet reduces splanchnic energy use, and therefore increases energy availability for use by peripheral tissues. The reductions in KPH and marbling score and increases in LMA in this study are carcass indicators for effects of repartitioning of energy from adipose tissue by RAC.…”

Section: Discussionmentioning

confidence: 92%

Effects of ractopamine hydrochloride supplementation on feeding behavior, growth performance, and carcass characteristics of finishing steers1,2

Trotta

Carlin

Swanson

2019

Translational Animal Science

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Ractopamine hydrochloride (RAC) is a β-adrenergic agonist that functions as a repartitioning agent to improve muscling in feedlot cattle. Many studies have investigated the effects of RAC on growth performance and carcass characteristics; however, there is minimal information about the influence of RAC on feeding behavior. Sixty-nine steers (body weight [BW] = 364 ± 3.9 kg) predominately of Angus and Simmental breeding were subjected to a 126-d (n = 46) or 154-d (n = 23) feeding period and randomly assigned to one of two treatment groups: supplementation to provide 0 (CON; n = 34) or 267 ± 4.9 mg/d of RAC (n = 35). Ractopamine was provided as Optaflexx 45 at 0.024% of the diet (dry matter [DM] basis; Elanco Animal Health, Greenfield, IN). Dietary treatments were fed the final 42 d in the feed yard (treatment period). Feeding behavior and growth performance were measured using radio frequency identification tags and the Insentec feeding system. Following the final day of treatment, steers were slaughtered and carcass measurements were recorded. Data were analyzed using MIXED models in SAS. There were no differences in BW, average daily gain (ADG), DM intake (DMI), gain:feed ratio (G:F), or feeding behavior during the pretreatment period (P > 0.44). Ractopamine supplementation increased G:F during the treatment period (P = 0.02) and during the total period (P = 0.03) and tended to increase ADG during the treatment and total period (P ≤ 0.08). DMI was not affected during the treatment or total period (P > 0.67). Eating time per visit, per meal, and per day were decreased (P < 0.02) in steers supplemented with RAC during the treatment period. DMI per minute was increased (P = 0.02) in steers supplemented with RAC. Hot carcass weight, dressing percentage, and 12th rib fat were not influenced by RAC supplementation. Ractopamine supplementation decreased marbling (P = 0.008) and kidney, pelvic, and heart percentage (P = 0.04) and increased longissimus muscle area (P = 0.01). These data demonstrate that RAC supplementation for 42 d improves feed efficiency, increases the rate of DMI without altering DMI, and increases muscling in finishing cattle.

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Effect of ractopamine on whole body and splanchnic energy metabolism in Holstein steers

Cited by 12 publications

References 29 publications

The Influence of Supplemental Zinc and Ractopamine Hydrochloride on Trace Mineral and Nitrogen Retention of Beef Steers

The Influence of Supplemental Zinc and Ractopamine Hydrochloride on Trace Mineral and Nitrogen Retention of Beef Steers

Influence of Anti-Coccidial Compounds and Phytogenic Saponin Extracts on In Vitro and In Vivo Ruminal Fermentation and Methane Production of Cattle

Effects of ractopamine hydrochloride supplementation on feeding behavior, growth performance, and carcass characteristics of finishing steers1,2

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