Effect of Radical Surgery for Advanced Adenocarcinoma of Esophagogastric Junction on Perioperative Cellular Cell Immunity

Li, Shoumiao; Gong, Yan-xin; Zhang, Zhizhong; Zhang, Wei; Liu, Zhiqiang; Li, Bao-zhong

doi:10.1080/08941939.2019.1606963

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Clinical Research Status Of Gastric Cancer Immunotherapy Bio...1

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2022

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“…High expression of LAG3 was found in patients who did not respond to chemotherapy [ 92 ]. Increased LAG3 expression was also observed in patients undergoing gastric cancer surgery [ 93 , 94 ].…”

Section: Clinical Research Status Of Gastric Cancer Immunotherapy Bio...mentioning

confidence: 99%

Advances in molecular biomarkers research and clinical application progress for gastric cancer immunotherapy

Cai

Deng

et al. 2022

Biomark Res

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Gastric cancer is characterized by high morbidity and mortality worldwide. Early-stage gastric cancer is mainly treated with surgery, while for advanced gastric cancer, the current treatment options remain insufficient. In the 2022 NCCN Guidelines for Gastric Cancer, immunotherapy is listed as a first-line option for certain conditions. Immunotherapy for gastric cancer mainly targets the PD-1 molecule and achieves therapeutic effects by activating T cells. In addition, therapeutic strategies targeting other molecules, such as CTLA4, LAG3, Tim3, TIGIT, and OX40, have also been developed to improve the treatment efficacy of gastric cancer immunotherapy. This review summarizes the molecular biomarkers of gastric cancer immunotherapy and their clinical trials.

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Section: Clinical Research Status Of Gastric Cancer Immunotherapy Bio...mentioning

confidence: 99%

Advances in molecular biomarkers research and clinical application progress for gastric cancer immunotherapy

Cai

Deng

et al. 2022

Biomark Res

View full text Add to dashboard Cite

show abstract

Effect of Radical Surgery for Advanced Adenocarcinoma of Esophagogastric Junction on Perioperative Cellular Cell Immunity

Cited by 1 publication

References 32 publications

Advances in molecular biomarkers research and clinical application progress for gastric cancer immunotherapy

Advances in molecular biomarkers research and clinical application progress for gastric cancer immunotherapy

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