Effect of Radioactive Iodine Therapy on Parotid Gland Function

Maier, H.; Bihl, H.

doi:10.3109/00016488709107290

Cited by 33 publications

(24 citation statements)

References 14 publications

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“…In 1 prospective study, parotid saliva composition alterations that correspond to an acute sialoadenitis were found 1 wk after radioiodine treatment (14), whereas 2 cross-sectional studies on 2. Displayed are changes in stimulated whole saliva flow rate for each of the 67 study subjects, ordered by basal flow rate.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study

et al. 2016

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Complaints of a dry mouth (xerostomia) and sialoadenitis are frequent side effects of radioiodine treatment in differentiated thyroid cancer (DTC) patients. However, detailed prospective data on alterations in salivary gland functioning after radioiodine treatment ( 131 I) are scarce. Therefore, the primary aim of this study was to prospectively assess the effect of high-activity radioiodine treatment on stimulated whole saliva flow rate. Secondary aims were to study unstimulated whole and stimulated glandular (i.e., parotid and submandibular) saliva flow rate and composition alterations, development of xerostomia, characteristics of patients at risk for salivary gland dysfunction, and whether radioiodine uptake in salivary glands on diagnostic scans correlates to flow rate alterations. Methods: In a multicenter prospective study, whole and glandular saliva were collected both before and 5 mo after radioiodine treatment. Furthermore, patients completed the validated xerostomia inventory. Alterations in salivary flow rate, composition, and xerostomia inventory score were analyzed. Salivary gland radioiodine uptake on diagnostic scans was correlated with saliva flow rate changes after radioiodine treatment. Results: Sixtyseven patients (mean age ± SD, 48 ± 17 y; 63% women, 84% underwent ablation therapy) completed both study visits. Stimulated whole saliva flow rate decreased after ablation therapy (from 0.92 [interquartile range, 0.74-1.25] to 0.80 [interquartile range, 0.58-1.18] mL/min, P 5 0.003), as well as unstimulated wholeand stimulated glandular flow rates (P , 0.05). The concentration of salivary electrolytes was similar at both study visits, whereas the output of proteins, especially amylase (P , 0.05), was decreased. The subjective feeling of dry mouth increased (P 5 0.001). Alterations in saliva flow rate were not associated with semiquantitatively assessed radioiodine uptake in salivary glands on diagnostic scans. For the small cohort of patients undergoing repeated radioiodine therapy, we could not demonstrate alterations in salivary parameters. Conclusion: We prospectively showed that salivary gland function is affected after high-activity radioiodine ablation therapy in patients with DTC. Therefore, more emphasis should be placed on salivary gland dysfunction during follow-up for DTC patients receiving high-activity radioiodine treatment.

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Section: Discussionmentioning

confidence: 99%

“…Detailed, prospective data on salivary gland function by measurement of whole or glandular saliva flow rates (sialometry) including analysis of saliva composition (sialochemistry) are scarce for DTC patients (14). When such data are available, these may provide us with detailed knowledge on the effects of radioiodine treatment on salivary gland function.…”

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confidence: 99%

Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study

et al. 2016

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“…Maier and Bihl (1987) hypothesized that injury of the acinar and ductal cells is secondary to damage of the vasculature of the gland following radiation damage to the dividing endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

Sialadenitis following radioiodine therapy – a new diagnostic and treatment modality

Nahlieli

Nazarian

2006

Oral Diseases

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“…Die Bedeutung der PHI in der Pathogenese der entzündlichen und der strahleninduzierten Parotitis wurde mehrfach belegt [7,8,10]. Lysozym (Ly) ist die Hauptkomponente der bakteriziden Wirkung des Speichels.…”

Section: Klinisch-sialochemischeunclassified

Quantitative Untersuchungen an den Enzymen Lysozym und Phosphohexoseisomerase im Mischspeichel beim oralen Plattenepithelkarzinom

Meyer¹,

Zechel²

2001

HNO

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In the mixed saliva of the OPC patients, the PHI concentration was significantly diminished according to the Mann-Whitney-Wilcoxon test compared to the control group (p = 0.022). The lysozyme concentration, however, significantly increased (p = 0.011). These results prove serious sialochemical alterations in mixed saliva of OPC patients. They extend our former studies on kallikrein in glandular mixed saliva, but at present only have a descriptive character. Further pathobiochemical investigations on this subject should be carried out.

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Effect of Radioactive Iodine Therapy on Parotid Gland Function

Cited by 33 publications

References 14 publications

Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study

Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study

Sialadenitis following radioiodine therapy – a new diagnostic and treatment modality

Quantitative Untersuchungen an den Enzymen Lysozym und Phosphohexoseisomerase im Mischspeichel beim oralen Plattenepithelkarzinom

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