1983
DOI: 10.3109/03639048309044678
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Effect of Re-Conpression on the Properties of Tablets Prepared by Dry Granulation

Abstract: The e f f e c t o f re-compression on t h e t a b l e t i n g p r o p e r t i e s o f some d i r e c t compression e x c i p i e n t s ( d i r e c t l y compressible s t a r c h , d i c a l c i u m phosphate d i h y d r a t e and m i c r o c r y s t a l l i n e c e l l u l o s e ) and t h e i r f o r m u l a t i o n s was examined. Re-compression g e n e r a l l y reduced t h e t a b l e t s t r e n g t h and t h i s r e d u c t i o n was more s i g n i f i c a n t when t h e i n i t i a l compaction was c a r… Show more

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Cited by 102 publications
(45 citation statements)
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“…High E/P y ratio is related to the large plastic zone and significant degree of material surrounding the indenter, which could consequently be displaced upward along the plastic flow. A certain percent of pharmaceutical materials possess strain-hardening properties (72)(73)(74). In such cases, the material becomes harder with subsequent plastic deformations, which constrains its upward flow.…”
Section: Pile-up and Sink-inmentioning
confidence: 99%
“…High E/P y ratio is related to the large plastic zone and significant degree of material surrounding the indenter, which could consequently be displaced upward along the plastic flow. A certain percent of pharmaceutical materials possess strain-hardening properties (72)(73)(74). In such cases, the material becomes harder with subsequent plastic deformations, which constrains its upward flow.…”
Section: Pile-up and Sink-inmentioning
confidence: 99%
“…EXCG present higher intrinsic plastic deformation (3) than SDEG (10), mostly related to the excipients on the formulation. Besides, EXCG is a product of wet granulation and SDEG of dry granulation, and, in general terms, dry granulation products lose their plastic deformation capacity during this technological process (34). This explains the situation showed in Fig.…”
Section: Tablets Produced In Rtmmentioning
confidence: 55%
“…Jahrhunderts unternahm H I T E [1,2] Versuche zur Konservierung von Milch und Fleisch und anderen Lebensmitteln mittels Hochdruck. Seit diesem Zeitpunkt ist bekannt, dass höherer hydrostatischer Druck Einfluss auf Mikroorganismen und andere biologische Zellen und Zellkompartimente ausübt, was zu einer ausgedehnten Forschung auf dem Gebiet der Hochdrucktechnik in Bezug auf Mikroorganismen und biologische Zellen führte [3,4].…”
Section: Hpds-hochdruckzelle Zurunclassified