Effect of Reaction Temperature on Shape Evolution of Palladium Nanoparticles and Their Cytotoxicity against A-549 Lung Cancer Cells

Abstract

Palladium nanoparticles (Pd NPs) of different shapes and sizes have been synthesized by reducing potassium tetrachloropalladinate(II) by l-ascorbic acid (AA) in an aqueous solution phase in the presence of an amphiphilic nonionic surfactant poly ethylene glycol (PEG) via a sonochemical method. Materials have been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray soectrscopy (EDX), Fourier transform infrared (FTIR), surface-enhanced Raman spectroscopy (SERS), particle distribution, and zeta potential studies. Truncated octahedron/fivefold twinned pentagonal rods are formed at room temperature (RT) (25 °C) while hexagonal/trigonal plates are formed at 65 °C. XRD results show evolution of anisotropically grown, phase-pure, and well crystalline face-centered cubic Pd NPs at both temperatures. FTIR and SERS studies revealed adsorption of ascorbic acid (AA) and PEG at NP’s surface. Particle’s size distribution graph indicates formation of particles having wide size distribution while the zeta potential particle surface is negatively charged and stable. The truncated octahedron/fivefold twinned pentagonal rod-shaped Pd NPs, formed at RT, while thermally stable and kinetically controlled hexagonal/trigonal plate-like Pd NPs, evolved at higher temperature 65 °C. The obtained Pd NPs have a high surface area and narrow pore size distribution. To predict protein reactivity of the Pd cluster, docking has been done with DNA and lung cancer-effective proteins. The cytotoxicity of the Pd NPs has been screened on human lung cancer cells A-549 at 37 °C. The biological adaptability exhibited by Pd NPs has opened a pathway in biochemical applications.

One-Pot Surface Modification of β-Cu2O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

“…The FESEM images of cuprous oxide nanoparticles (β-Cu 2 O NPs) of cuprite phase show that the size and morphology are in good agreement to represent their importance that affects the interaction of biological cell membranes and thus represent their biological action as recently reported by Abbas et al with palladium nanoparticles with A-549 lung carcinoma cell lines. 84 This observation suggested that the grafted compound is coated on β-Cu 2 O NPs to keep them adjacently close to each other (Figure 7a−d). Large particles have a lower specific surface area than smaller particles, leading to a high energy of the latter.…”

“…Moradi et al proposed the fabrication of copper oxide catalyst on biochar nanoparticles for the synthesis of tetrazoles as antimicrobial agents . Abbas et al have proposed the effect of reaction temperature and shape evolution of palladium nanoparticles and their cytotoxicity against A-549 lung cancer cells . Shi et al proposed the effect of surface chemistry on the generation of reactive oxygen species by copper nanoparticles .…”

“…54 Abbas et al have proposed the effect of reaction temperature and shape evolution of palladium nanoparticles and their cytotoxicity against A-549 lung cancer cells. 55 Shi et al proposed the effect of surface chemistry on the generation of reactive oxygen species by copper nanoparticles. 56 The study of ROS-generating capacity of uniform copper nanoparticles with different capping ligands leads to a better understanding of the relationship between the physicochemical properties and toxicological potential of nanoparticles as reflected by ROS generation in an acellular assay.…”

Targeting the ACE2 receptor using nanomedicine: Novel approach to lung cancer therapy

“…Increased anticancer effects with increased concentration Selenium [33] A549 Delivery of paclitaxel Inhibition of cell growth, invasion, migration Palladium [41] A549 Chemically synthesized nanoparticles Dose-dependent cytotoxicity Silver [42] A549 Bio-synthesised AgNPs from of Pinus roxburghii needles Induced apoptosis and increased intracellular ROS in cells…”

Solanum Nigrum Leaf Extract Capped Copper Oxide Nanoparticles and its Tetrahedral L2Cu(ɳ2-BH4) Complex for Effective Degradation of Congo Red

“…5 inset). The higher Loading [MathJax]/jax/output/CommonHTML/fonts/TeX/fontdata.js surface area of SN@CuO NPs indicates the presence of large number of catalytic sites and is thus expected to show high catalytic properties (Abbas et al 2019).…”