Effect of reactive oxygen species and the activity of antioxidant systems on human semen; association with male infertility

Sanocka, Dorota; Miesel, Ralf; Jȩdrzejczak, Piotr; Chełmońska-Soyta, Anna; Kurpisz, Maciej

doi:10.1046/j.1365-2605.1997.00050.x

Cited by 60 publications

(54 citation statements)

References 33 publications

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“…They are categorized as enzymatic and nonenzymatic antioxidants ( Table 2) [67]. Enzymatic antioxidants contain superoxide dismutase (SOD), catalase, and glutathione peroxidase.…”

Section: Antioxidants In Human Semenmentioning

confidence: 99%

Reactive Oxygen Species and Sperm Cells

Takeshima¹,

Kuroda²,

Yumura³

2018

Reactive Oxygen Species (ROS) in Living Cells

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Many cases of male factor infertility are idiopathic, but 30-40% of cases may have excessive levels of reactive oxygen species (ROS) in their semen. The origins of endogenous ROS are leukocytes and immature spermatozoa, and external causes are various. On the contrary, seminal plasma contains various antioxidants. Low levels of ROS are essential for the fertilization process, but excessive levels of ROS lead to oxidative stress and can have harmful effects such as lipid peroxidation of a membrane, sperm deoxyribonucleic acid fragmentation, and apoptosis on the fertile capacity. In order to evaluate oxidative stress appropriately, ROS is measured by the chemiluminescence method with neat semen and quantification of 8-OH-2′-deoxyguanosine and malondialdehyde in seminal plasma. Antioxidant potential is often measured using total antioxidant capacity (TAC) assay. The oxidation-reduction potential measured by a MiOXSYS analyzer is a novel, easier, quicker, and less expensive technology to measure oxidative stress. In order to minimize oxidative stress and improve clinical outcomes, sperm-sorting methods, lifestyle modifications, shortening the ejaculatory abstinence, and treatments such as oral antioxidants, varicocelectomy, and testicular sperm extraction are taken into account. As a future prospect, proteomics, metabolomics, and genomics are still developing areas that have the potential to discover new findings and highly sensitive biomarkers.

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“…They are categorized as enzymatic and nonenzymatic antioxidants ( Table 2) [67]. Enzymatic antioxidants contain superoxide dismutase (SOD), catalase, and glutathione peroxidase.…”

Section: Antioxidants In Human Semenmentioning

confidence: 99%

Reactive Oxygen Species and Sperm Cells

Takeshima¹,

Kuroda²,

Yumura³

2018

Reactive Oxygen Species (ROS) in Living Cells

View full text Add to dashboard Cite

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“…Oxidative stress occurs due to the presence of hydroxyl radicals, superoxide anions and hydrogen peroxide present in either the ejaculate or the female reproductive tract fluids. In the event of sperm DNA damage, including that acquired from oxidative stress, pregnancy failure or pathologies can ensue due to embryonic loss [48,49]. To counteract the detrimental effects of these oxidative agents seminal plasma is rich in powerful antioxidant agents such as catalase and superoxide dismutase [50].…”

Section: Inseminationmentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

127

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The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre-and peri-implantation period of early pregnancy is critical for implantation success and optimal foetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of metabolic disorders such as obesity, hypertension and insulin resistance. It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.

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“…The endogenous free radical scavenging enzymes in the male reproductive tract include superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) [14,[30][31][32][33]. These same antioxidant enzymes (SOD, catalase and GPX) are found in semen [34]. Moreover, several nonenzymatic antioxidants (e.g.…”

Section: Semen Antioxidants and Sperm Dna Damagementioning

confidence: 99%

Antioxidants and sperm DNA damage: a clinical perspective

Zini

Gabriel

Baazeem

2009

J Assist Reprod Genet

178

110

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Purpose Infertile men possess substantially more sperm DNA damage than do fertile men, damage that may impact negatively on reproductive outcomes. In this era of assisted reproductive technologies there is mounting concern regarding the safety of utilizing DNA-damaged spermatozoa in this setting. Therefore, it is important to identify strategies that may reduce sperm DNA damage. The purpose of this review is to discuss the rationale for antioxidant therapy in men with sperm DNA damage and to evaluate the data on the efficacy of dietary and in vitro antioxidant preparations on sperm DNA damage. Methods We reviewed the literature on antioxidants and sperm DNA damage. Results To date, the data suggest that dietary antioxidants may be beneficial in reducing sperm DNA damage, particularly, in men with high levels of DNA fragmentation. However, the mechanism of action of dietary antioxidants has not been established and most of the clinical studies are small. A beneficial effect of in vitro antioxidant supplements in protecting sperm DNA from exogenous oxidants has been demonstrated, however, the effect of these antioxidants in protecting sperm from endogenous ROS, gentle sperm processing and cryopreservation has not been established.

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Effect of reactive oxygen species and the activity of antioxidant systems on human semen; association with male infertility

Cited by 60 publications

References 33 publications

Reactive Oxygen Species and Sperm Cells

Reactive Oxygen Species and Sperm Cells

Seminal fluid and reproduction: much more than previously thought

Antioxidants and sperm DNA damage: a clinical perspective

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