Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model

Abstract

These experiments confirm that SOD, diltiazem, and dexamethasone can decrease adhesion formation. The absence of effect from the other antiinflammatory drugs and anti-TNF-alpha is surprising.

Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: In vitro and in vivo characterization

“…Figure 1: Hypothetic subdivision of the abdominal cavity [41] . Tables Table 1: Qualitative adhesion scoring system [40] Category Score Extent -No adhesion -1-25% of the peritoneal cavity involved -26-50% of the peritoneal cavity involved -51-75% of the peritoneal cavity involved -76-100% of the peritoneal cavity involved …”

“…In addition, adhesions were qualified and quantified in a blinded manner using three scoring systems. Qualitative adhesion scoring was based on extent, type and tenacity of adhesions, as described by with some modifications [40], [41] as displayed in Table 1. Adhesions were assessed according to the quantitative scoring system reported in Egea et al (1995) with some modifications [41], [42] as displayed in Table 2.…”

“…Adhesions were qualified and quantified using standard scoring systems. The qualitative adhesion scoring (Table 1) was based on extent, type and tenacity of adhesions, as described by [40], [41] with some modifications.…”

Antitumor Effect of Natural Product Molecules against Lung Cancer

“…In recent lung cancer therapies, targeting ROS signaling was thought to be a striking method [33]. Notably, smoke-oxidative stress results in DNA damage and restrains survival signaling, which make proliferation out of control during the transfer of lung epithelial cells [34][35][36]. Few studies have shown that some herbal extracts and their components can eliminate active oxygen in lung cancer cells.…”

Investigation of antioxidant properties of some 6-(α-aminobenzyl)thiazolo[3,2-b]-1,2,4-triazole-5-ol compounds

“…Many NSAIDs are known to act either by inhibiting the production of free radicals or by scavenging them [1,4]. Since COX enzymes are believed to involve oxygen radical intermediates (5), treatments with some NSAIDs at therapeutic doses significantly diminish free oxygen radical dependent injuries at the inflammation site by inhibiting COX enzymes (5,6).…”