Investigation of antioxidant properties of some 6-(α-aminobenzyl)thiazolo[3,2-b]-1,2,4-triazole-5-ol compounds

Abstract

Promising antiinflammatory activity together with low ulcerogenic properties of some Michael addition products of thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones which have been synthesized in our previous study, prompted us to investigate their antioxidant properties. Since compound Ib has both antioxidant and antiinflammatory activities beside the lowest ulcerogenic incidence, it was selected for investigation of its inhibitory effect on various cyclooxygenase ezymes. It was found that while it did not inhibit cyclooxygenase-1 (COX-1) enzyme, there was a small inhibitory effect (17%) on COX-2 enzyme. We concluded that the diminished harmful effects on the stomach of this novel antiinflammatory compound were related to its antioxidant properties since it is ineffective on COX-1 enzyme. In conclusion, the compounds having both antioxidant and antiinflammatory activities with a lack of COX-1 enzyme inhibitory effect may improve the gastrointestinal safety profile of such compounds.

Syntheses and Biological Activities of New Hybrid Molecules Containing Different Heterocyclic Moieties

“…Several classes of compounds have been reported as antiurease agents, such as hydroxamic acids , phosphoramidates , polyphenols , 1,2,4‐triazoles, 1,3,4‐oxadiazoles, and 1,3,4‐thiadiazoles . Furthermore, some Schiff base‐metal complexes have been found to possess urease inhibitory effects , along with other metal complexes .…”

Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus

“…In addition, some 1,2,4-triazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles have also been reported as the compounds possessing antiurease activity (Amtul et al ., 2004; Aktay et al ., 2009; Bekircan et al ., 2008). Recently, some complexes of Schiff bases with metal ions showed significant inhibitory activities against urease (Shi et al, 2007; You et al, 2010) along with other metal complexes (Cheng et al, 2009).…”

Pharmacological significance of triazole scaffold

“…The diminished harmful effects on the stomach of these novel anti-inflammatory compounds were related to their antioxidant properties since it is ineffective on COX-1 enzyme. In conclusion, the compounds having both antioxidant and anti-inflammatory activities with a lack of COX-1 enzyme inhibitory effect may improve the gastrointestinal safety profile of such compounds [83]. …”