Effect of recombinant PDGF-BB on bone formation in the presence of β-tricalcium phosphate and bovine bone mineral matrix: a pilot study in rat calvarial defects

Luvizuto, Eloá Rodrigues; Tangl, Stefan; Dobsak, Toni; Reich, Karoline Maria; Gruber, Reinhard; Sonoda, Celso Koogi; Okamoto, Roberta

doi:10.1186/s12903-016-0210-3

Cited by 18 publications

(10 citation statements)

References 18 publications

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“…The MPM kit consisted of four 9-mL tubes without anticoagulant, one 9-mL preparation tube, two sterile containers, 0.5 cc β-TCP bone graft, and a 6-mL injection syringe. Growth factors are susceptible to β-TCP granules and show satisfactory effects on tissue regeneration [54,55]. Xenogeneic bone graft materials resorb slowly and growth factors are not affinitive to xenografts.…”

Section: Discussionmentioning

confidence: 99%

Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

Çinar

Gültekin

Saglanmak

et al. 2020

IJERPH

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This randomized controlled clinical trial evaluated the effect of mineralized plasmatic matrix (MPM), comprised of synthetic graft and platelet concentrates, on new bone formation and volume stability over time in maxillary sinus lifting (MSL). Unilateral MSL was performed in 20 patients with either beta-tricalcium phosphate (β-TCP) or MPM grafts (10 sinuses each). Six months postsurgery, specimens were obtained with a trephine bur prior to implant placement in 39 cases. Volumetric changes in sinus augmentation were analyzed between 1 week (T-I) and 6 months (T-II) postsurgery. Histomorphometric and histological analyses of biopsy samples revealed mean new bone percentages of 35.40% ± 9.09% and 26.92% ± 7.26% and residual graft particle areas of 23.13% ± 6.16% and 32.25% ± 8.48% in the MPM and β-TCP groups, respectively (p < 0.05). The mean soft-tissue areas in the MPM and β-TCP groups were 41.48% ± 8.41% and 40.83% ± 8.86%, respectively (p > 0.05). Graft reductions between baseline and 6-months postprocedure in the β-TCP and MPM groups were 17.12% ± 13.55% and 14.41% ± 12.87%, respectively, with significant graft volume reduction observed in both groups (p < 0.05) while there is no significant difference between MPM and β-TCP groups (p > 0.05). Thus, MPM, representing growth factors in a fibrin network, increases new bone formation and has acceptable volume stability in MSL procedures

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Section: Discussionmentioning

confidence: 99%

Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

Çinar

Gültekin

Saglanmak

et al. 2020

IJERPH

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“… Xie et al (2014) found that the secreted PDGF-BB from preosteoclasts increased type H vessel numbers and bone formation during bone modeling remodeling. In contrast to the mentioned studies, Luvizuto et al (2016) reported that the supplementation of biomaterials with PDGF-BB had no remarkable effects on bone formation. Despite the beneficial effects, PDGF-BB has a short half-life within the blood; thus, local and sustained delivery of PDGF-BB is essential to achieve ideal outcomes.…”

Section: Importance Of Angiogenesis In Bone Development and Repairmentioning

confidence: 69%

Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis

Yang²,

Liu³

et al. 2023

Front. Pharmacol.

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Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/stem cells, scaffold, and growth factors/biochemical cues. Among the various biomaterial scaffolds, hydrogels are broadly used in bone tissue engineering owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, and osteoinductive properties. During bone tissue engineering, angiogenesis plays a central role in the failure or success of bone reconstruction via discarding wastes and providing oxygen, minerals, nutrients, and growth factors to the injured microenvironment. This review presents an overview of bone tissue engineering and its requirements, hydrogel structure and characterization, the applications of hydrogels in bone regeneration, and the promising roles of hydrogels in bone angiogenesis during bone tissue engineering.

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“…Moreover, collagen membranes releasing PDGF enhanced the regeneration of mandibular defects compared to conventional collagen membranes (Yamano, Haku, Yamanaka, Dai & Takayama, ). On the contrary, adding PDGF‐BB to TCP and DBBM did not impact on the regeneration of calvarial CSDs in rats (Luvizuto, Tangl, Dobsak, Reich & Gruber, ; Silva de Oliveira, Okamoto, Sonoda, Poi & Garcia Junior, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Effect of recombinant PDGF-BB on bone formation in the presence of β-tricalcium phosphate and bovine bone mineral matrix: a pilot study in rat calvarial defects

Cited by 18 publications

References 18 publications

Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis

The use of bioactive factors to enhance bone regeneration: A narrative review

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