Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits

Zou, Jiangang; Wang, Zhirong; Ya, Huang; Cao, Ke; Wu, Joseph M.

doi:10.3892/ijmm.11.3.317

Cited by 73 publications

(76 citation statements)

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“…The impairment of the NO pathway seen in inactive aging mice [38,65] has been shown to be prevented by EX or an antioxidant treatment [20,79]. Interestingly, EX permitted the maintenance of a better vascular function in cerebral arteries than CAT in all conditions, demonstrating that EX is more potent at protecting the cerebral circulation than a single antioxidant intervention.…”

Section: Adaptive Mechanismsmentioning

confidence: 99%

Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice

Leblond

Nguyen

Bolduc

et al. 2013

Pflugers Arch - Eur J Physiol

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We aimed to evaluate the lasting functional imprinting of exercise (EX) and catechin (CAT) on the vascular function of middle-age mice switched to a proatherogenic environment. C57BL/6J mice (n=10-15 in each group) fed a regular diet (RD) were exposed from the age of 1 to 9 months either to EX (voluntary running; 2.7± 0.2 km/day), to the polyphenol CAT (30 mg/kg/day in drinking water), or to physical inactivity (PI). At 9 months of age, EX and CAT were stopped and mice either remained on the RD or were fed a Western diet (WD) for an additional 3 months. At 12 months of age, mice from all groups fed a WD had similar body mass, systolic blood pressure, and plasma total cholesterol, glucose, insulin, and isoprostane. Compared to the RD, the WD induced an indomethacin-sensitive aortic endothelium-dependent and independent dysfunction in PI mice (p<0.05) that was prevented by both EX and CAT; this benefit was associated with a higher (p< 0.05) non-nitric oxide/non-prostacyclin endothelium-dependent relaxation. While EX, but not PI or CAT, prevented vascular dysfunction induced by the WD in cerebral arteries, it had no effect in femoral arteries. The profiles of activity of antioxidant enzymes and of proinflammatory gene expression in the aorta suggest a better adaptation of EX>CAT>PI mice to stress. In conclusion, our data suggest that a postnatal exposure to EX, but not to CAT, imprints an adaptive defense capacity in the vasculature against a deleterious change in lifestyle.Correspondence to: Eric Thorin.eric.thorin@umontreal.ca. Electronic supplementary material The online version of this article

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Section: Adaptive Mechanismsmentioning

confidence: 99%

Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice

Leblond

Nguyen

Bolduc

et al. 2013

Pflugers Arch - Eur J Physiol

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“…There is accumulating evidence that resveratrol can exert anti-oxidant effects in biological systems via multiple direct and indirect mechanisms, including effects on ROS and NO production, lipid peroxidation, endogenous antioxidant systems, all of which may contribute to the cardiovascular benefits of the compound [12,14,15,[54][55][56][57][58]. Resveratrol, in a relatively high concentration [59,60], was reported to elicit vasodilation both in large conduit arteries and in vessels of the microcirculation in animal models (Fig.…”

Section: Anti-oxidant Effects Of Resveratrolmentioning

confidence: 99%

Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen

Labinskyy¹,

Csiszár²,

Veress³

et al. 2006

CMC

Self Cite

132

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Epidemiological studies demonstrated that even in the absence of other risk factors (e.g. diabetes, hypertension, hyperhomocysteinemia, hypercholesterolemia), advanced age itself significantly increases cardiovascular morbidity by enhancing vascular oxidative stress and inflammation. Because the population in the Western world is rapidly aging, there is a substantial need for pharmacological interventions that delay the functional decline of the cardiovascular system. Resveratrol is an atoxic phytoestrogen found in more than 70 plants including grapevine and berries. Recent data suggest that nutritional intake of resveratrol and other polyphenol compounds may contribute to the "French paradox", the unexpectedly low cardiovascular morbidity in the Mediterranean population. There is increasing evidence that resveratrol exerts multifaceted antioxidant and/or anti-inflammatory effects in various disease models. Importantly, resveratrol was reported to slow aging and increase lifespan in simple organisms and has been suggested as a potential calorie restriction mimetic. Resveratrol has also been reported to activate NAD-dependent histone deacetylases (sirtuins), which may contribute to its anti-aging effects. This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds.

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“…53,[56][57][58] At pharmacological doses, resveratrol increases vascular nitric oxide (NO) levels and improves NO bioavailability in animal models. [59][60][61][62][63][64] NO in the vasculature is constitutively synthesized by endothelial NO synthase (eNOS) and plays a crucial role in maintaining cardiovascular homeostasis. 65,66) NO relaxes vascular smooth muscle cells, thereby upregulating blood flow, and it prevents thrombogenic and atherogenic processes by vasodilatory and anti-aggregatory effects.…”

Section: Link To Enosmentioning

confidence: 99%

Recent Advances in the Study on Resveratrol

Nakata

Takahashi

Inoue

2012

Biological & Pharmaceutical Bulletin

152

112

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Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.

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Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits

Cited by 73 publications

References 0 publications

Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice

Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice

Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen

Recent Advances in the Study on Resveratrol

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