Effect of Red Wine on Adipocytokine Expression and Vascular Alterations in Fructose-Fed Rats

Vazquez-Prieto, Marcela Alejandra; Renna, Nicolás Federico; Diez, Emiliano; Cacciamani, Valeria; Lembo, Carina; Miatello, Roberto

doi:10.1038/ajh.2010.214

Cited by 24 publications

(30 citation statements)

References 40 publications

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“…Several studies have shown that adipose tissue contributes to the modulation of changes in a variety of bioactive adipocytokines, such as adiponectin, leptin, visfatin, and resistin, leading to vascular injury and target organ damage [38, 39]. In the current study, the high-fructose diet significantly reduced serum adiponectin levels and increased serum leptin, resistin, and visfatin levels by increasing adipose Ang II expression.…”

Section: Discussionsupporting

confidence: 48%

Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats

et al. 2017

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Renin–angiotensin system in visceral fat plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats. However, the effects of renin inhibition on visceral adiposity in metabolic syndrome are not fully investigated. We investigated the effects of renin inhibition on visceral adiposity in fructose-fed rats. Male Wistar–Kyoto rats were divided into 4 groups for 8-week experiments: Group Con (standard chow diet), Group Fru (high-fructose diet; 60% fructose), Group FruA (high-fructose diet and concurrent aliskiren treatment; 100 mg/kg body weight [BW] per day), and Group FruB (high-fructose diet and subsequent, i.e. 4 weeks after initiating high-fructose feeding, aliskiren treatment; 100 mg/kg BW per day). The high-fructose diet induced metabolic syndrome, increased visceral fat weights and adipocyte sizes, and augmented angiotensin II (Ang II), NADPH oxidase (NOX) isoforms expressions, oxidative stress, and dysregulated production of adipocytokines from visceral adipose tissues. Concurrent and subsequent aliskiren administration ameliorated metabolic syndrome, dysregulated adipocytokines, and visceral adiposity in high fructose-fed hypertensive rats, and was associated with reducing Ang II levels, NOX isoforms expressions and oxidative stress in visceral fat tissues. Therefore, this study demonstrates renin inhibition could improve metabolic syndrome, and reduce Ang II levels and oxidative stress in visceral fat tissue in fructose-fed rats, and suggests that visceral adipose Ang II plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats.

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Section: Discussionsupporting

confidence: 48%

Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats

et al. 2017

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“…While promoting the expression of adiponectin, a fat-derived adipokine that exerts powerful anti-inflammatory effects, ethanol or wine ingestion also reduced the release of inflammatory cytokines and pro-inflammatory mediators from human adipose tissue under basal conditions and following exposure to lipopolysaccharides [13,212,213]. …”

Section: Ethanol Exerts Anti-inflammatory Effects In I/r: Cellularmentioning

confidence: 99%

Moderate ethanol ingestion and cardiovascular protection: From epidemiologic associations to cellular mechanisms

Krenz¹,

Korthuis²

2012

Journal of Molecular and Cellular Cardiology

141

148

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While ethanol intake at high levels (3-4 or more drinks), either in acute (occasional binge drinking) or chronic (daily) settings, increases the risk for myocardial infarction and ischemic stroke, an inverse relationship between regular consumption of alcoholic beverages at light to moderate levels (1-2 drinks per day) and cardiovascular risk has been consistently noted in a large number of epidemiologic studies. Although initially attributed to polyphenolic antioxidants in red wine, subsequent work has established that the ethanol component contributes to the beneficial effects associated with moderate intake of alcoholic beverages regardless of type (red versus white wine, beer, spirits). Concerns have been raised with regard to interpretation of epidemiologic evidence for this association including heterogeneity of the reference groups examined in many studies, different lifestyles of moderate drinkers versus abstainers, and favorable risk profiles in moderate drinkers. However, better controlled epidemiologic studies and especially work conducted in animal models and cell culture systems have substantiated this association and clearly established a cause and effect relationship between alcohol consumption and reductions in tissue injury induced by ischemia/reperfusion (I/R), respectively. The aims of this review are to summarize the epidemiologic evidence supporting the effectiveness of ethanol ingestion in reducing the likelihood of adverse cardiovascular events such as myocardial infarction and ischemic stroke, even in patients with co-existing risk factors, to discuss the ideal quantities, drinking patterns, and types of alcoholic beverages that confer protective effects in the cardiovascular system, and to review the findings of recent experimental studies directed at uncovering the mechanisms that underlie the cardiovascular protective effects of antecedent ethanol ingestion. Mechanistic interrogation of the signaling pathways invoked by antecedent ethanol ingestion may point the way towards development of new therapeutic approaches that mimic the powerful protective effects of socially relevant alcohol intake to limit I/R injury, but minimize the negative psychosocial impact and pathologic outcomes that also accompany consumption of ethanol.

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“…The mass of abdominal fat expressed as a percentage of the body weight has been previously used as a measure of body composition in rats (16). No statistically significant change was observed in this percentage due to PTU (11.3±1%) or T 4 (9.1±0.6%) treatments compared with controls (11.5±0.7%), although the HyperT rats had a tendency to show lower values.…”

Section: Induction Of Hypothyroidism and Hyperthyroidismmentioning

confidence: 72%

Experimental hypothyroidism increases apoptosis in dimethylbenzanthracene-induced mammary tumors

et al. 2013

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Abstract. Epidemiological and in vitro data have not provided conclusive evidence concerning the involvement of thyroid hormones (THs) on mammary carcinogenesis. We used an in vivo model to assess the relationship between THs, adipose tissue and breast cancer development. Female Sprague-Dawley rats were treated with a dose of 7,12-dimethylbenz(a)anthracene (15 mg/rat) at 55 days of age and were then divided into four experimental groups: hypothyroid rats (HypoT, 0.01% 6-N-propyl-2-thiouracil in drinking water), untreated control (EUT); hyperthyroid rats (HyperT, 0.25 mg/kg/day T 4 s.c.) and vehicle-treated control rats. The latency of tumor appearance and the incidence and progression of tumors were determined. At sacrifice, blood samples were collected for hormone determinations and samples of tumor and mammary glands were obtained for immunohistological studies. HypoT rats had retarded growth and an increase in mammary fat. The latency was longer (p<0.0001), the incidence rate was lower (p<0.05) and tumor growth was slower in HypoT rats compared to EUT and HyperT rats. Mitotic index and PCNA immunostaining were similar in all groups. HypoT rats showed increased apoptosis (p<0.05) as evaluated by the apoptotic index and TUNEL staining. No differences in serum prolactin and progesterone were observed. However, circulating estradiol (E 2 ) was significantly lower in HypoT and HyperT rats. Serum leptin levels were reduced in HypoT rats even though the abdominal fat mass was similar in all groups. To note, the leptin level was higher in HypoT rats that developed mammary tumors than the level in non-tumoral HypoT rats. In conclusion, hypothyroidism altered animal growth, breast morphology, body composition, leptin secretion and serum E 2 enhancing apoptosis and, consequently, retarding mammary carcinogenesis in rats.

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Effect of Red Wine on Adipocytokine Expression and Vascular Alterations in Fructose-Fed Rats

Abstract: In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines and attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that nonalcohol components of RW are responsible for the beneficial effects.

Cited by 24 publications

References 40 publications

Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats

Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats

Moderate ethanol ingestion and cardiovascular protection: From epidemiologic associations to cellular mechanisms

Experimental hypothyroidism increases apoptosis in dimethylbenzanthracene-induced mammary tumors

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