Effect of Reducing Pigmentation by Collagen Peptide Intake: A Randomized, Double-Blind, Placebo-Controlled Study

Abstract

Introduction:We examined the effect of 5.0 g/day of collagen peptide (CP) or collagen peptide fermented with Aspergillus sojae (FCP) on skin pigmentation in healthy participants. Methods: In this randomized, double-blind, placebo-controlled study, 44 men and women aged 25-63 years were placed into three groups by stratified random allocation and treated with CP, FCP, or placebo (PL) at 5.0 g/day for 3 months. Their skin condition was measured monthly from baseline to 3 months of intake. Results: No adverse events were identified in any group. The CP group showed a significant reduction in pigmented patches and redness after 1 and 3 months of intake, respectively. In the FCP group, pigmented macules were significantly reduced after 1 month, and pigmented patches after 2 months. Both the allages analysis and the hierarchical analysis below 55 years old yielded similar results. Conclusion: Intake of 5.0 g/day of FCP for 3 months is safe. CP and FCP intake is useful for suppressing pigmentation. In addition, CP intake may be useful for reducing redness. These results suggest a new beneficial effect on the skin of CP supplementation. Trial Registration: UMIN clinical trials registry system, UMIN000040736.

Ceftriaxone-Loaded Polymeric Microneedles, Dressings, and Microfibers for Wound Treatment

“…For the lower layer, collagen was a significant factor as it significantly decreased erythema ( p -value < 0.05). Himeno et al [ 17 ] showed that collagen can reduce irritation because it decreases inflammation and also has a skin-remodeling function. PEG had a significant quadratic effect that increased the breaking strength because PEG, together with Kollicoat ® Protect, reduces the intermolecular forces of the polymer, increasing its mobility and allowing the polymer chains to move more freely, giving it greater flexibility and strength [ 18 ].…”

“…Application of these formulations decreases erythema compared with the control wound. This is due to the components of the formulations, such as D-panthenol and collagen, which have been shown to reduce inflammation and improve the healing process [ 17 , 22 ].…”

Efek Nutrasetikal Kolagen Terhadap Kesehatan Kulit

“…Kemerahan dan pigmentasi pada kulit disebabkan oleh paparan sinar matahari. Berdasarkan studi Himeno et al (2022) kolagen peptida memiliki efek yang lebih baik dalam mengurangi kemerahan kulit dan pigmentasi lebih cepat dibanding kolagen peptida yang difermentasi (FCP), sedangkan pada Ito et al (2018) kolagen peptida dapat menurunkan kemerahan pada kulit [1], [15]. Namun dikarenakan studi yang dilakukan memiliki ukuran sampel yang kecil disamping banyak faktor yang dapat berkontribusi terhadap kemerahan kulit seperti faktor metabolisme dan usia atau faktor luar seperti gaya hidup (paparan UV, suhu dingin, penggunaan tabir surya, sauna, dan obat-obatan antihipertensi) maka studi lanjutan diperlukan.…”

“…Kolagen memiliki komposisi asam amino yang unik. Gabungan molekul kolagen ini membentuk kolagen fibril dengan berikatan silang (tripel heliks) dengan konfigurasi (Gli-X-Y)n dengan X dan Y biasanya prolin dan hidroksiprolin [14], [15]. Selanjutnya kolagen fibril ini bergabung untuk membentuk serat kolagen [1], [12].…”

“…Penuaan kulit seperti organ tubuh lainnya memang tidak dapat dihindari. Penelitian-penelitian yang dilakukan dilakukan dengan tujuan menemukan cara mengurangi dan meminimalkan efek buruk yang disebabkan oleh penuaan kulit [2], [3], [15], [16]. Penurunan kolagen akibat usia dapat dikurangi dengan pemberian suplemen kolagen per oral karena memberikan efek sistemik yang lebih baik [12], [18].…”