Effect of Regulator of G Protein Signaling Proteins on Bone

Yuan, Gongsheng; Yang, Shuying

doi:10.3389/fendo.2022.842421

Cited by 10 publications

(10 citation statements)

References 62 publications

(96 reference statements)

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“…Su Yin Lim et al found that CCL2-CCR2 signaling is a key process in cancer metastasis 43 . G protein-coupled receptor (GPCR) and regulators of G protein signaling (RGS) family proteins are involved in a variety of diseases such as cancer, arthritis, metabolic dysfunctions, and aging-related diseases [44][45][46][47][48][49][50][51][52][53][54][55][56] . Wendy Kleibeuker et al found that physiological changes of G protein-coupled receptor kinase 2 (GRK2) control CCL2-induced signaling 57 .…”

Section: Discussionmentioning

confidence: 99%

Identification of key molecules and biological processes in TCF21 treated tumor pericytes

Zhao

Zhang

Wang

2022

Preprint

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Colorectal cancer has become a major public health problem in the US. Transcription factor 21 (TCF21) is reported to be silenced in colorectal cancer tissues. However, the mechanism of TCF21 in tumor pericytes is still unclear. In our study, we aim to identify the key biological processes and signaling pathways by analyzing the RNA-seq data. The GSE200064 was produced by the Illumina NovaSeq 6000 (Homo sapiens). The KEGG and GO analyses showed that MAPK signaling pathway and complement/coagulation cascades are the major changed signaling pathways in the progression of tumor pericytes with overexpression of TCF21. Moreover, we identified several interactive molecules including VEGFA, MMP2, CCL2, COL3A1, COL1A2, CXCL12, ELN, PDGFRB, VWF, and APOE. These findings may benefit the study of colorectal cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Identification of key molecules and biological processes in TCF21 treated tumor pericytes

Zhao

Zhang

Wang

2022

Preprint

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“…Andre Luiz Prezotto Villa et al reported that the PPARG expression is related to cancer stages and clinical evolution 39 . G protein-coupled receptors are widely expressed in cells and their downstream signaling pathways are involved in a number of pathological processes [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] Our study identi ed the potential vital molecules and signaling pathways related to the LDHA-mediated PDAC. This study showed that TNF signaling pathway and Cellular senescence are the major processes during the LDHA treatment.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional landscapes and signaling pathways of LDHA inhibitor treated pancreatic ductal adenocarcinoma

Chang¹,

Qian

2022

Preprint

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Lactate dehydrogenase (LDHA) is a metabolism-related enzyme that is involved in the progression of several cancers such as pancreatic ductal adenocarcinoma (PDAC). However, the mechanism of LDHA regulates the PDAC is largely unknown. In this study, we analyzed the RNA-seq data of LDHA inhibitor-treated PDAC cells and identified the transcriptional landscapes of these cells. We used the gene enrichment assays including KEGG and GO to further analyzed the potential signaling pathways. In addition, we constructed the PPI network and Reactome map to further identified the biological processes. We found the TNF signaling pathway and Cellular senescence are the major signaling pathways that involve the LDHA inhibitor-treated PDAC cells. We identified the top ten interactive genes including FN1, CCND1, HDAC1, NFKBIA, PPARG, HSPA5, AURKB, CXCR4, RUNX2, and IRF1. Our study may provide novel mechanisms for the treatment of PDAC.

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“…Similarly, Z Huang et al found that CDK1 increases the interaction of SOX2 to further enhance the stemness of lung cancer cells 15 . G protein-coupled receptors are essential for cell functions and are involved in several diseases [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] . P M Cobelens et al found that hydrogen peroxide damages GRK2 (GPCRrelated protein) via calpain and cdk1-mediated signaling pathway 35 .…”

Section: Discussionmentioning

confidence: 99%

Differentially expressed gene profile and relevant pathways of the inhibition of LAMP5 on MLL-rearranged leukemias

Qian

Zhang

2022

Preprint

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LAMP5 is a lysosome-related protein, which showed increased expression levels in MLL-r leukemia. Recent findings showed that LAMP5 is involved in MLL-fusion protein but the specific mechanism is still unclear. In our study, we aim to identify the transcriptional landscapes of the LAMP5-shRNA-treated MLL-r leukemia cells. We used the gene enrichment analyses such as KEGG and GO to further analyze the potential signaling pathways. Moreover, we constructed the PPI network and Reactome map to further identify the biological processes. We found that Lysosome and Cell Cycle are the major signaling pathways involved in the LAMP5-shRNA treated MLL-r leukemia cells. We identified the top ten interactive genes including CDK1, TOP2A, PLK1, CCNA2, ASPM, BUB1, BUB1B, CCNB1, AURKA, and KIF11. Our study may provide novel mechanisms for the treatment of MLL-r leukemia by inhibiting LAMP5.

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Effect of Regulator of G Protein Signaling Proteins on Bone

Cited by 10 publications

References 62 publications

Identification of key molecules and biological processes in TCF21 treated tumor pericytes

Identification of key molecules and biological processes in TCF21 treated tumor pericytes

Transcriptional landscapes and signaling pathways of LDHA inhibitor treated pancreatic ductal adenocarcinoma

Differentially expressed gene profile and relevant pathways of the inhibition of LAMP5 on MLL-rearranged leukemias

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