Effect of Remote Ischemic Preconditioning on Outcome of Elective Percutaneous Coronary Intervention

Rashed, Ahmed; Abdeldayem, Mohamed; Farag, Nabil; Rami, Raymond; El-Naggar, Wael; Sabet, Sameh; Elramly, Mohamed; El-Haddad, Mohamed A.; Torki, Ahmed; Mostafa, Amany A.

doi:10.1016/s0735-1097(11)61094-2

Cited by 2 publications

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“…Note that their study involved only 54 patients, with just 11 undergoing arm RIP, while the rest had coronary balloon occlusion as an RIPC stimulus [10] . In 2011, Rashed et al [13] assessed whether remote ischemic preconditioning reduces myonecrosis and inflammation in PCI patients using cardiac biomarkers (CK, CKMB, Cardiac troponin T) and CRP. The RIPC group had significantly lower post-procedural cardiac troponin T levels (0.020 vs. 0.047 ng/mL in the control group, p=0.047) and fewer postprocedural myocardial infarctions (6 vs. 12 patients in the control group).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Remote Ischemic Preconditioning on The Outcome of Elective Percutaneous Coronary Intervention

Rasheed,

Attia,

Ibrahim

et al. 2023

Benha Journal of Applied Sciences

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Background: Remote ischemic preconditioning (IPC) is a potential cardioprotective strategy in the context of elective percutaneous coronary intervention (PCI). This study aimed to assess its impact on post-procedural cardiac myonecrosis, as measured by cardiac troponin I (cTnI), and its association with major adverse cardiac events (MACE) at 6-month follow-up. The objective of this study was to investigate whether remote IPC, administered prior to elective PCI, reduces cTnI levels, ischemic symptoms, ECG evidence of ischemia, and the occurrence of MACE. Methods: This prospective study was conducted involving 200 patients with significant coronary artery stenosis who underwent elective PCI. Patients were divided into two groups: Group A received remote IPC through blood pressure cuff inflations and deflations, while Group B served as the control. Various parameters, including patient demographics, cardiac risk factors, ECG findings, lesion complexity, and MACE rate, were assessed. Results: Both groups exhibited similar baseline characteristics, with no significant differences in age, gender, cardiac risk factors, ECG findings, and lesion complexity. Remote IPC was associated with a significant reduction in cTnI levels at 24 hours post-PCI and a lower incidence of unstable angina and overall MACE. No significant differences were observed in other procedural outcomes or adverse events between the groups. Conclusions: This study suggests that remote IPC administered prior to elective PCI has the potential to mitigate post-procedural cardiac damage, as indicated by reduced cTnI levels, and may be associated with a lower incidence of MACE.

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Section: Discussionmentioning

confidence: 99%

The Effect of Remote Ischemic Preconditioning on The Outcome of Elective Percutaneous Coronary Intervention

Rasheed,

Attia,

Ibrahim

et al. 2023

Benha Journal of Applied Sciences

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“…Recent meta-analyses demonstrated that RIPC reduces biomarkers in patients undergoing CABG (92,135). The 2 follow-up studies with clinical outcomes were single-center trials, not powered to demonstrate definitive answers about clinical outcome (114,120). The consistency of the beneficial clinical outcome in the studies adds credibility to a clinically relevant benefit of RIC in relation to CABG and elective PCI.…”

Section: Effects Of Ric On the Heart: Elective Ischemia/reperfusionmentioning

confidence: 99%

Remote Ischemic Conditioning

Belaoussoff¹,

Ganske²,

Redington

2017

J Cardiovasc Pharmacol Ther

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Remote ischemic conditioning (RIC) is at a pivotal point in its evolution, both in terms of its adoption as a therapy and its viability commercially. The most usual way of inducing RIC, with a standard blood pressure cuff and a stopwatch, is time-consuming and potentially inaccurate and unsafe. Development of automated devices have facilitated large-scale randomized trials and will make clinical deployment of the technique more straightforward. Both the medical and commercial future of RIC will depend on the results of upcoming phase 3 pivotal trials.

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Effect of Remote Ischemic Preconditioning on Outcome of Elective Percutaneous Coronary Intervention

Cited by 2 publications

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The Effect of Remote Ischemic Preconditioning on The Outcome of Elective Percutaneous Coronary Intervention

The Effect of Remote Ischemic Preconditioning on The Outcome of Elective Percutaneous Coronary Intervention

Remote Ischemic Conditioning

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