Effect of repeated oral administration of butachlor and lead alone and in combination on haematobiochemical parameters in wistar rats

Abstract

The experiment was carried out to evaluate the rising concern over additive effect of one chemical with another chemical which have raised a lot of health concern in general population. In the experiment, adult wistar rats of either sex were divided into 4 groups and study was conducted for a period of 28 days. Group I served as control and was provided with water only for drinking purposes. Animals of group II were administered butachlor @262 mg/kg B.W/P.O. Group III recieved administered lead acetate @265 ppm orally while animals of group IV received combination of butachlor @262 mg/kg and lead acetate @265 ppm. Group IV animals showed significant (P<0.05) decrease in levels of Hemoglobin, Packed cell volume, Total erythrocyte count, Lymphocytes, Monocytes levels while significant (P<0.05) increase was observed in Neutrophil, Eosinophils, Basophil, Erythrocyte sedimentation rate. Elevated levels of blood biochemical indices like phosphatases (ACP & ALP), aminotransferases (AST & ALT), Creatinine, BUN was also observed in group IV.