The experiment was carried out to evaluate the rising concern over additive effect of one chemical with another chemical which have raised a lot of health concern in general population. In the experiment, adult wistar rats of either sex were divided into 4 groups and study was conducted for a period of 28 days. Group I served as control and was provided with water only for drinking purposes. Animals of group II were administered butachlor@262mg/kg B.W/P.O. Group III recieved administered lead acetate@265ppm orally while animals of group IV received combination of butachlor@262mg/kg and lead acetate@265ppm. Oxidative stress was revealed by significant increase in lipid peroxidation and decrease in blood glutathione, glutathione peroxidase and transferase, catalase and superoxide dismutase in blood and tissues respectively. Histopathologically, liver and and kidney exhibited structural alterations as compared to control. The study concluded butachlor and lead produced more deleterious systemic effect in combination than alone (additive toxic effect).

The experiment was carried out to evaluate the rising concern over additive effect of one chemical with another chemical which have raised a lot of health concern in general population. In the experiment, adult wistar rats of either sex were divided into 4 groups and study was conducted for a period of 28 days. Group I served as control and was provided with water only for drinking purposes. Animals of group II were administered butachlor @262 mg/kg B.W/P.O. Group III recieved administered lead acetate @265 ppm orally while animals of group IV received combination of butachlor @262 mg/kg and lead acetate @265 ppm. Group IV animals showed significant (P<0.05) decrease in levels of Hemoglobin, Packed cell volume, Total erythrocyte count, Lymphocytes, Monocytes levels while significant (P<0.05) increase was observed in Neutrophil, Eosinophils, Basophil, Erythrocyte sedimentation rate. Elevated levels of blood biochemical indices like phosphatases (ACP & ALP), aminotransferases (AST & ALT), Creatinine, BUN was also observed in group IV.