Effect of Resistance, Endurance, and Concurrent Training on TNF-α, IL-6, and CRP

Libardi, Cleiton Augusto; Souza, Giovana; Cavaglieri, Cláudia Regina; Madruga, Vera Aparecida; Chacon-Mikahil, Mara Patrícia Traina

doi:10.1249/mss.0b013e318229d2e9

Cited by 151 publications

(131 citation statements)

References 22 publications

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“…Recently, Bateman et al (22) and Slentz et al (23) found significant changes in body mass and waist circumference after 8 months of training in obese individuals. In contrast, however, others did not find an effect of combined training on these anthropometric variables (37 ns -not significant concerning the impact of combined training on body composition are more consistent. In line with our findings, a decrease in fat mass and an increase in lean body mass after 12 weeks and 8 months of exercise, respectively, were previously reported (23,24).…”

Section: Discussionmentioning

confidence: 78%

Effects of Supervised vs Non-Supervised Combined Aerobic and Resistance Exercise Programme on Cardiometabolic Risk Factors

Stefanov

Vekova²,

Bonova³

et al. 2013

Cent Eur J Public Health

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SUMMARYObjective: We examined the effect of a 6-month combined aerobic and resistance training programme on cardiometabolic risk factors in nondiabetic subjects and compared its effectiveness when executed under strict professional supervision or without direct supervision.Methods: Eighty-five sedentary, non-diabetic subjects (27 men and 58 women), mean age 47.5±0.6 years, mean body mass index (BMI, 33.8±0.6 kg/m 2 ) participated in a combined exercise programme assigned to supervised (S, n=31), non-supervised (NS, n=24) or control group (C, n=30). Cardiometabolic risk parameters were assessed at baseline and after the 6-month training.Results: In both the S and NS group there was a significant decrease in BMI (−1.6±0.3, p<0.001 and −1.0±0.3 kg/m 2 , p=0.004), waist circumference (−10.1±1.1 cm, p<0.001 and −7.8±0.8 cm, p<0.001), fat mass (−1.8±0.4%, p<0.001 and −2.1±0.6%, p=0.003), and a significant increase in fat-free mass (+1.7±0.4%, p<0.001 and +2.0±0.7%, p=0.008), and aerobic capacity (+6.9±1.1, p<0.001 and +6.9±0.8 ml/kg per min, p=0.008). Fasting glucose did not change in S and NS, but increased in C (p=0.048). In the S group a significant decrease in fasting insulin (p<0.001), homeostasis model assessment of insulin resistance (p<0.001), highly sensitive C-reactive protein (p=0.004), leucocytes count (p=0.04), systolic high (p<0.001) and diastolic (p=0.009) blood pressure was found. Comparable significant decreases in total and low-density lipoprotein cholesterol were observed in all study groups.Conclusions: A 6-month combined exercise programme led to substantial improvement of various cardiometabolic risk factors. This programme was effective even when executed without direct supervision, although the effects were more pronounced in the supervised group. Our findings suggest that non-supervised exercise programmes may be a valuable, cost-effective tool to translate the current physical activity guidelines in a real-life setting.

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Section: Discussionmentioning

confidence: 78%

Effects of Supervised vs Non-Supervised Combined Aerobic and Resistance Exercise Programme on Cardiometabolic Risk Factors

Stefanov

Vekova²,

Bonova³

et al. 2013

Cent Eur J Public Health

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“…A positive effect of resistance training on circulating IL-6 after a single exercise was noted in previously sedentary elderly women and middle-aged men [82,83]. contrarily, no effect of resistance, endurance or concurrent training on IL-6 response to a single exercise session was noted following 16 weeks of training in a group of middle-aged men [84]. Moreover, 12 weeks of aerobic training (five days a week at 50 % of VO 2 max) did not change plasma IL-6 concentrations in obese women despite the decrease in body fat and improvement in insulin sensitivity [85].…”

Section: Il-6 Response To Trainingmentioning

confidence: 88%

Interleukin-6 as an adipokine and myokine: the regulatory role of cytokine in adipose tissue and skeletal muscle metabolism

Lutosławska

2018

Hum Mov.

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Purpose. Interleukin-6 (IL-6) belongs to the IL-6-type cytokine family, which, besides IL-6, comprises of IL-11, leukemia inhibitory factor (LIF), oncostatin M (OsM), ciliary neurotrophic factor (cNTF), cardiotrophin-1 (cT) and cardiotrophin-like cytokine (cLc). The metabolic effects of IL-6 differ markedly depending on the nature of the target cell with positive action on nerve cells' differentiation and hematopoesis, but negative in the etiology of autoimmune disease such as rheumatoid arthritis. In a target cell, IL-6 can simultaneously generate functionally distinct or sometimes contradictory signals depending on the in vivo environment, and the final physiological effect is a consequence of the orchestration of the diverse signals. Thus, its physiological effects are characterized by pleiotropy and redundancy. At present, it has been well documented that in obese individuals, IL-6, as an adipokine secreted into circulation by adipose tissue in proportion to body fat content and an elevated level of the cytokine in the plasma, adversely affects insulin signaling and glucose disposal in skeletal muscles and liver. Moreover, several lines of evidence indicated that IL-6 is a myokine synthesized in skeletal muscle and secreted into the bloodstream in response to exercise. In this way muscular work has a potential to stimulate adipose tissue lipolysis and provides an energy to working muscle. Furthermore, muscle-originated IL-6 acts locally, positively affecting intramuscular fat utilization. It has also been postulated that IL-6 is inevitable for satellite cell stimulation and muscle hypertrophy and repair.

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“…The test was considered maximum if at least two of the following criteria were met: a) exhaustion or inability to maintain the required speed; b) HR at or above 200 bpm, and c) respiratory exchange ratio (RER) equal to or greater than one. Maximum oxygen consumption (VO 2max) was calculated as described above 22 .…”

Section: Cardiorespiratory Fitnessmentioning

confidence: 99%

“…In the treatment of obese adolescents, combined exercises has been used with excellent metabolic 20 and inflammatory responses 14 and seems to more effective in improving the visceral fat than aerobic training alone 21 , and induce the same effects in fitness that isolated aerobic and resistance training do 22 . Nevertheless, the impact that the Glu27 allele may have on inflammatory parameters in response to combined training have not been assessed.…”

Section: Introductionmentioning

confidence: 99%

ADRB2 Gln27Glu polymorphism influenced changes in leptin but not body composition or metabolic and other inflammatory parameters after twelve weeks of combined training in overweight adolescents

Leite

Silva

Jesus

et al. 2018

Motriz: rev. educ. fis.

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-Aim:To compare the anthropometric, metabolic, and inflammatory parameters of overweight adolescents after 12-weeks of resistance and aerobic training (CT), taking into account the Gln27Glu polymorphism of the β2 adrenergic receptor (ADRB2) gene. Methods: Forty-seven adolescents (15.05±1.07y) were assigned to one of four groups, according to the presence or absence of the Glu27 allele: CT (CarrierT n=11; NoncarrierT n=11) or control (CarrierC n=13; NoncarrierC n=12). Body composition, abdominal fat, maturation, fitness, metabolic and lipid profile, inflammatory markers were assessed. The CT consisted of six resistance exercises, followed by 30 min of walking/ running at 50-80% VO 2max , totaling 60 min/session, three times a week. A mixed-model factorial ANOVA was used to compare variables at baseline and after 12-weeks. Results: TC was effective in reducing total fat mass (NoncarrierT ES=.45, CarrierT ES=.27) and subcutaneous abdominal fat (NoncarrierT ES=.48, CarrierT ES=.46) and increasing lean mass (NoncarrierT ES=.58, CarrierT ES=.60) and fitness. CarrierT group showed a reduction in leptin (ES=.49). Conclusion:The responses of body composition and physical fitness to TC were not influenced by the presence of the Gln27Glu polymorphism. However, only the Glu27 allele carriers showed reductions in leptin after 12-weeks. Besides, a lack of intervention caused obesogenic effects, especially in Glu27carriers.

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Effect of Resistance, Endurance, and Concurrent Training on TNF-α, IL-6, and CRP

Cited by 151 publications

References 22 publications

Effects of Supervised vs Non-Supervised Combined Aerobic and Resistance Exercise Programme on Cardiometabolic Risk Factors

Effects of Supervised vs Non-Supervised Combined Aerobic and Resistance Exercise Programme on Cardiometabolic Risk Factors

Interleukin-6 as an adipokine and myokine: the regulatory role of cytokine in adipose tissue and skeletal muscle metabolism

ADRB2 Gln27Glu polymorphism influenced changes in leptin but not body composition or metabolic and other inflammatory parameters after twelve weeks of combined training in overweight adolescents

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