Effect of Restoration of Euthyroidism on Peripheral Blood Cells and Erythropoietin in Women with Subclinical Hypothyroidism

Abstract

Overall, we observed subtle alterations of the leuco-lympho-monocytic distribution of the peripheral blood cells upon restoration of euthyroidism in patients with SCH. Hemoglobin and Hematocrit remained unchanged; however, the increasing level of erythropoietin during L-T4 treatment suggests an already stimulated, yet compensated erythropoietic system in mild thyroid failure.

Characteristics of anemia in subclinical and overt hypothyroid patients

“…There was normocytic anemia in overt hypothyroid patients, subclinical hypothyroid patients and normal subject respectively 34%, 26%, 16.5% (p=0.02). levothyroxine treatment in women with subclinical hypothyroidism [3]. Also in our study, similar with the literature the most frequent anemia type was anemia of chronic disease and ratio was higher in overt hypothyroid group according to the control group (p=0.007).…”

Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study

“…[14,[20][21][22] To the best of our knowledge, this is the first study to report the prevalence of thyroiditis-induced anemia in non-pregnant females during the childbearing age in Saudi Arabia. The present study showed thyroid abnormalities in 19.6% of the study population and the most common thyroid disorders were subclinical hypothyroidism followed by overt hypothyroidism.…”

“…[8,16] It has been suggested that thyroid hormone deficiency may lead to bone marrow repression and/or decrease in erythropoietin production due to the reduction of O 2 requirements. [20] Hypochromic microcytic anemia is less frequently associated with hypothyroidism and it is mainly due to iron deficiency. [20][21][22] The results of the present study are in agreement with the previous reports as normocytic normochromic anemia and microcytic hypochromic anemia were the only two types of anemia detected.…”

“…[20] Hypochromic microcytic anemia is less frequently associated with hypothyroidism and it is mainly due to iron deficiency. [20][21][22] The results of the present study are in agreement with the previous reports as normocytic normochromic anemia and microcytic hypochromic anemia were the only two types of anemia detected. The frequency of both types was significantly higher in hypothyroidism compared to normal thyroid group.…”

“…[8,15,16] Furthermore, it has been found that all hematological parameters return to normal when a euthyroid state is achieved. [14,[20][21][22][23] Females are more prone to the development of thyroid disorders and/or anemia, especially during the reproductive age and pregnancy. [2,3,6,7,12] Little is known about the incidence of thyroid disorders and their associated types of anemia in Saudi Arabia.…”