Effect of resveratrol and β-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells

.BETA.-Sitosterol Induces Anti-proliferation and Apoptosis in Human Leukemic U937 Cells through Activation of Caspase-3 and Induction of Bax/Bcl-2 Ratio

“…Awad et al 23,24) reported that b-sitosterol arrested human prostate and breast cancer cells in the G2/M phase of the cell cycle and induced apoptosis. These results suggest that the growth inhibitory and apoptosis inducing effects of b-sitosterol are the result of a block during this G2/M phase and that such cells do not enter the G1 phase.…”

“…[12][13][14] Previous studies have shown that b-sitosterol reduces carcinogen-induced cancer of the colon in rats, 15) and exhibits anti-inflammatory, 16,17) anti-angiogenic 18) and immune-modulating properties. 19,20) Several studies have indicated that b-sitosterol inhibits the growth of various cultured cancer cell lines that are associated with the activation of the sphingmyelin cycle, 21,22) cell cycle arrest 23,24) and the stimulation of apoptotic cell death. 25,26) Although b-sitosterol is one of the major phytosterols detected in the blood, the underlying mechanisms of its action are not completely understood in leukemic cells.…”

Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer

“…The inhibition of P450 by resveratrol can reduce the reactive activation of molecular oxygen. Resveratrol is able to prevent the increase in ROS following exposure to oxidative agents such as tobacco-smoke condensate (TAR), H 2 O 2 , phorbol esters, ultraviolet radiation [35][36][37], and to decrease and scavenge ROS [38,39]. It appears that resveratrol is an effective scavenger of hydroxyl, superoxide, and metal-induced radicals.…”

“…3). Indeed, resveratrol can block the G1/S transition of the cell cycle [39,64,[119][120][121][122]. Resveratrol is able to act at this point by decreasing the protein expression of cyclin D1, D2, E and the protein expression of cdk 2, 4, 6 and the activities of kinases examined in various cancer cell lines (Fig.…”

Sphaeranthus indicus Induces Apoptosis Through Mitochondrial-Dependent Pathway in HL-60 Cells and Exerts Cytotoxic Potential on Several Human Cancer Cell Lines

“…The anticancer activity in the plant extract were attributable primarily to β-sitosterol, which is a well-established steroidal compound having prominent activity against benign prostatic hyperplasia and prostatic cancer cell lines. 10,11 We screened S indicus, Ganoderma lucidum (a mushroom), and Urtica dioica for their cytotoxicity against human cancer cell lines and found S indicus to be the most effective in inhibiting the proliferation of prostate cancer cell lines, that is, PC-3 and DU-145. The petroleum ether, ethanolic, and aqueous extracts of the test drugs were screened for their in vitro cytotoxicity.…”