Effect of resveratrol release kinetic from electrospun nanofibers on osteoblast and osteoclast differentiation

Riccitiello, Francesco; Luise, Adriana De; Conte, Romana; DAniello, Sharon; Vittoria, Vittoria; Salle, Anna Di; Calarco, Anna; Peluso, Gianfranco

doi:10.1016/j.eurpolymj.2017.12.035

Cited by 40 publications

(30 citation statements)

References 57 publications

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“…Thus, based on the evidence above, we concluded that resveratrol promoted osteoblastic differentiation and suppressed osteoclastic differentiation in postmenopausal osteoporosis rats. The results were consistent with the reported regulatory effects of resveratrol on osteoblasts and osteoclasts [39,40]. Ma et al found that resveratrol rescued the suppression of osteoblast differentiation caused by LPS [39].…”

Section: Discussionsupporting

confidence: 88%

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Resveratrol promotes osteoblastic differentiation in a rat model of postmenopausal osteoporosis by regulating autophagy

et al. 2020

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Objective: Resveratrol is a natural polyphenolic compound that ameliorates postmenopausal osteoporosis by activating the estrogen receptor. Research has shown that resveratrol exhibits some type of estrogen receptor agonist activity, reducing the risk of breast cancer. However, its mechanism of action remains largely unknown. This study aims to investigate the effect of resveratrol on osteoblastic and osteoclastic differentiation and its potential role in the regulation of autophagy. Methods: Sprague Dawley (SD) rats underwent ovariectomies (OVX) and were administered resveratrol (at 10, 20 or 40 mg/kg/d) for 8 weeks. The calcium content and the bone mineral density (BMD) were measured in the lumbar vertebrae (L3) and the right distal femur-tibia bone region. The osteoblasts and osteoclasts were isolated from rat lumbar vertebrae by enzyme digestion and bone marrow induction, respectively. The cells were then cultured with resveratrol in combination with bafilomycin or leupeptin to inhibit or activate autophagy, respectively. Western blotting was used to assess the differentiation markers and autophagy-related genes in the osteoblasts and osteoclasts. Results: Compared to the sham group, the bone calcium content and BMD were significantly decreased in the OVX group (p < 0.05), while resveratrol attenuated these in a dose-dependent manner. In the osteoblasts, vascular endothelial growth factor (VEGF), and alpha-1 type I collagen (COL1A1) were markedly decreased, and in osteoclasts, the receptor activator of nuclear factor-κB ligand (RANKL) was increased in the OVX group, while resveratrol reversed this pattern in a dose-dependent manner. The inhibition of autophagy in osteoblasts and its activation in osteoclasts was observed in the OVX group. However, with resveratrol, this was reversed in a dosedependent manner. Conclusion: Overall, resveratrol promotes osteoblastic differentiation and suppresses osteoclastic differentiation in a rat model with postmenopausal osteoporosis by regulating autophagy.

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Section: Discussionsupporting

confidence: 88%

“…Ma et al found that resveratrol rescued the suppression of osteoblast differentiation caused by LPS [39]. In addition, PCL and poly (lactic) acid (PLA) loading resveratrol inhibited osteoclast differentiation [40].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol promotes osteoblastic differentiation in a rat model of postmenopausal osteoporosis by regulating autophagy

et al. 2020

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“…Similarly, Riccitiello et al used RSV (a drug used to influence bone osteogenesis by decreasing RANKL mediated osteoclastogenesis) to prepare electrospun nanofibers. The fiber showed sustained release of resveratrol (RSV) and dental pulp stem cells (DPSCs) and expressed less RANKL while osteoclast precursors were unable differentiate into mature osteoclasts . Collectively, the approaches using functionalized biomaterials for regulating osteoclastogenesis have still been limited to several molecules, however, the role of various biological factors regulating the osteoclast activity has become clearer.…”

Section: Biomaterials For Modulation Of Osteoclastogenesismentioning

confidence: 99%

Current Advances in Immunomodulatory Biomaterials for Bone Regeneration

Lee

Byun

Perikamana

et al. 2018

Adv Healthcare Materials

342

267

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Biomaterials with suitable surface modification strategies are contributing significantly to the rapid development of the field of bone tissue engineering. Despite these encouraging results, utilization of biomaterials is poorly translated to human clinical trials potentially due to lack of knowledge about the interaction between biomaterials and the body defense mechanism, the “immune system”. The highly complex immune system involves the coordinated action of many immune cells that can produce various inflammatory and anti‐inflammatory cytokines. Besides, bone fracture healing initiates with acute inflammation and may later transform to a regenerative or degenerative phase mainly due to the cross‐talk between immune cells and other cells in the bone regeneration process. Among various immune cells, macrophages possess a significant role in the immune defense, where their polarization state plays a key role in the wound healing process. Growing evidence shows that the macrophage polarization state is highly sensitive to the biomaterial's physiochemical properties, and advances in biomaterial research now allow well controlled surface properties. This review provides an overview of biomaterial‐mediated modulation of the immune response for regulating key bone regeneration events, such as osteogenesis, osteoclastogenesis, and inflammation, and it discusses how these strategies can be utilized for future bone tissue engineering applications.

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“…Regenerative medicine aims to improve or repair the physiological function of tissues or organs through processes of replacement, engineering or regeneration. Dental treatments often require the replacement or repair of tissues that could be obtained by tissue engineering: we have discussed the main techniques to perform regenerative dentistry, involving stem cells, biomaterials and growth factors in combination or used alone [17][18][19][20]. Novel technologies and protocols have been demonstrated to be useful in bone and periodontal tissue regeneration.…”

Section: Conclusion and Future Insightsmentioning

confidence: 99%

Management of Endodontic and Periodontal Lesions: the Role of Regenerative Dentistry and Biomaterials

et al. 2020

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Regenerative dentistry represents a novel interdisciplinary approach involving biomaterials, several molecules and mesenchymal stem cells (MSCs), preferably derived from oral tissues. The pivotal role of MSCs depends on the fact that they can differentiate into different cell lineages and have the strategic role to release bioactive substances that stimulate the renewal and regeneration of damaged tissues. The role of regenerative dentistry is promising in all the branches of dentistry: the most intriguing application is related to the management of endodontic and periodontal defects, overcoming the surgical approach and the implantology as a consequence of a poorly efficient therapeutic plan.

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Effect of resveratrol release kinetic from electrospun nanofibers on osteoblast and osteoclast differentiation

Cited by 40 publications

References 57 publications

Resveratrol promotes osteoblastic differentiation in a rat model of postmenopausal osteoporosis by regulating autophagy

Resveratrol promotes osteoblastic differentiation in a rat model of postmenopausal osteoporosis by regulating autophagy

Current Advances in Immunomodulatory Biomaterials for Bone Regeneration

Management of Endodontic and Periodontal Lesions: the Role of Regenerative Dentistry and Biomaterials

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