Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials

Marx, Wolfgang; Kelly, Jaimon T; Marshall, Skye; Cutajar, Jennifer; Annois, Brigitte; Pipingas, Andrew; Tierney, Audrey C.; Itsiopoulos, Catherine

doi:10.1093/nutrit/nuy010

Cited by 59 publications

(43 citation statements)

References 39 publications

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“…However, results of resveratrol supplementation in human are inconsistent. A meta-analysis of randomized controlled trials suggests that resveratrol may be beneficial (Marx et al, 2018) or may have no significant impact on the selected measures of cognitive performance (Farzaei et al, 2018). Several neuroprotective properties of resveratrol have been suggested in the studies of its effects in the intracerebral hemorrhage (Bonsack et al, 2017), cerebral neurodamage (Nalagoni & Karnati, 2016), and central nervous system injuries such as stroke .…”

Section: Neuroprotectionmentioning

confidence: 99%

Health benefits of resveratrol administration

Aebisher²,

2019

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Resveratrol is a polyphenol which is abundant in grape skin and seeds. Sources of resveratrol in food also include wine, berries, and peanuts. This compound displays many properties including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, as well as aging. Due to the fact that resveratrol is generally well-tolerated, it is believed to be a promising compound in preventing many diseases such as diabetes and associated complications. Unfortunately, this compound exhibits low bioavailability and solubility. The aim of this review is to summarize recent information from in vitro and in vivo studies on animals and humans on the multiple effects of resveratrol on health and benefits of its intake.

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Section: Neuroprotectionmentioning

confidence: 99%

Health benefits of resveratrol administration

Aebisher²,

2019

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“…While no improvement in verbal memory was observed in elderly people after receiving RSV [46], the consumption of RSV enhances both cerebrovascular function and cognition in postmenopausal women [48]. In addition, meta-analysis [50] considers that RSV has no significant effect on memory improvement or cognitive performance. The possible reasons for these discrepancies could be due to variations in the protocol of RSV administration and the patient status.…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

“…Consumption of two of those capsules (150 mg) for 14 weeks enhances both cerebrovascular function and cognition in postmenopausal women aged 45-85 years [48]. In contrast, recent systematic reviews and meta-analysis, which included only clinical studies, RSV has no significant effect on memory improvement or cognitive performance as well as mood state [49,50]. A summary of the RSV preventive effects during elderly is shown in Figure 1.…”

Section: Resveratrol As a Possible Protective Agent Of Brain Aging: Ementioning

confidence: 99%

How efficient is resveratrol as an antioxidant of the Mediterranean diet, towards alterations during the aging process?

Silva

Sureda

Tur

et al. 2019

Free Radical Research

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Mediterranean diet (MD) is the most relevant nutritional aspect of the multisecular Mediterranean civilisation which includes wine as an element of health and wellbeing when consumed with moderation. Mediterranean meals provide food micronutrients which include polyphenols, especially resveratrol from grape and red wine. MD, also called Cretan diet, has been proven to prevent diseases including cardiovascular pathologies, cancer, and to prevent aging. Interestingly, the grape and more precisely in grape skin contains the highest concentration of RSV. In consequence, red wine is the most concentrated food source of RSV found in the human diet. This review topic deals to how efficient is RSV towards alterations during the aging process; obtained from recent data of clinical trials, preclinical studies, and cell culture approach; especially RSV protecting effect on brain aging of elderly; its role on the microglial cells playing a central role in the neuro-inflammation; and in its anti-inflammatory effects on ocular diseases.

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“…In contrast, Wightman et al [ 82 ] demonstrated a lack of any interpretable cognitive effects of 28 days’ supplementation with 500 mg resveratrol, although subjective fatigue was reduced. A recent meta-analysis reported beneficial effects of resveratrol on cognitive function [ 90 ]. However, only three studies out of the ten that were included in the analysis reported benefits, and two of these three studies administered resveratrol alongside other polyphenols (red wine and quercetin, respectively).…”

Section: Phenolicsmentioning

confidence: 99%

Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance

Kennedy

2019

Sports Med

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Subjective alertness and optimal cognitive function, including in terms of attention, spatial/working memory and executive function, are intrinsic to peak performance in many sports. Consumption of a number of plant-derived ‘secondary metabolite’ phytochemicals can modulate these psychological parameters, although there is a paucity of evidence collected in a sporting context. The structural groups into which these phytochemicals fall—phenolics, terpenes and alkaloids—vary in terms of the ecological roles they play for the plant, their toxicity and the extent to which they exert direct effects on brain function. The phenolics, including polyphenols, play protective roles in the plant, and represent a natural, benign component of the human diet. Increased consumption has been shown to improve cardiovascular function and is associated with long-term brain health. However, whilst short-term supplementation with polyphenols has been shown to consistently modulate cerebral blood-flow parameters, evidence of direct effects on cognitive function and alertness/arousal is currently comparatively weak. Terpenes play both attractant and deterrent roles in the plant, and typically occur less frequently in the diet. Single doses of volatile monoterpenes derived from edible herbs such as sage ( Salvia officinalis/lavandulaefolia ) and peppermint ( Mentha piperita ), diterpene-rich Ginkgo biloba extracts and triterpene-containing extracts from plants such as ginseng ( Panax ginseng/quinquefolius ) and Bacopa monnieri have all been shown to enhance relevant aspects of cognitive function and alertness. The alkaloids play toxic defensive roles in the plant, including via interference with herbivore brain function. Whilst most alkaloids are inappropriate in a sporting context due to toxicity and legal status, evidence suggests that single doses of nicotine and caffeine may be able to enhance relevant aspects of cognitive function and/or alertness. However, their benefits may be confounded by habituation and withdrawal effects in the longer term. The efficacy of volatile terpenes, triterpene-rich extracts and products combining low doses of caffeine with other phytochemicals deserves more research attention.

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Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials

Abstract: The results of this review indicate that resveratrol supplementation might improve select measures of cognitive performance; however, the current literature is inconsistent and limited.

Cited by 59 publications

References 39 publications

Health benefits of resveratrol administration

Health benefits of resveratrol administration

How efficient is resveratrol as an antioxidant of the Mediterranean diet, towards alterations during the aging process?

Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance

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