1999
DOI: 10.1016/s0099-2399(99)80355-0
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Effect of retinoic acid on osteopontin expression in rat clonal dental pulp cells

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Cited by 7 publications
(6 citation statements)
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“…These findings are supported by previous studies, which have shown that RA causes an increase in OPN synthesis in rat dental pulp cell line (Ohishi et al 1999), whereas the ALP activities of human dental pulp cells are promoted by RA (San Miguel et al 1999). Significant upregulation of SHED osteogenic gene expressions and ALP activity by RA treatment can be seen after only 7 days of treatment, whereas the matrix mineralization of the RA group can be easily detected after 21 days of treatment.…”
Section: Discussionsupporting
confidence: 86%
“…These findings are supported by previous studies, which have shown that RA causes an increase in OPN synthesis in rat dental pulp cell line (Ohishi et al 1999), whereas the ALP activities of human dental pulp cells are promoted by RA (San Miguel et al 1999). Significant upregulation of SHED osteogenic gene expressions and ALP activity by RA treatment can be seen after only 7 days of treatment, whereas the matrix mineralization of the RA group can be easily detected after 21 days of treatment.…”
Section: Discussionsupporting
confidence: 86%
“…Retinoic acid is a major regulator of chondrocytic maturation and matrix mineralization (20,21) and high intake of retinoids can lead to vascular calcification (22). Furthermore, in man retinoid treatment has been shown to lead to tendon and ligament calcification (23).…”
Section: ˾ Retinoic Acidmentioning
confidence: 99%
“…Compared with the osteogenic properties of the small molecules mentioned above, the effects on dental pulp cells or odontoblasts have not been extensively studied. Osteopontin expression in dental pulp cells of rats is increased by retinoic acid , and total flavonoids from Drynaria fortunei were reported to increase ALP activity and calcified nodule formation . However, the effects of purified flavonoids on dental pulp‐cell differentiation have not yet been examined.…”
mentioning
confidence: 99%