To further reveal the interaction between crossflow and jet, single oblique jet impingement in crossflow is studied. The influences of Reynolds number (Re = 3750–15,000), oblique angle (θ = 50°–90°), jet intake mode (jet normal to inlet plane and jet along hole axis), crossflow ratio (CR = 0.1–0.3) and temperature ratio (TR = 1.0–1.2) are considered. For both jet intake modes, with the decrease of θ, the peak value of Nusselt number increases and its location shifts upstream. The Nusselt number for case of jet normal to inlet plane is higher than that of jet along hole axis with wider lateral coverage range. The CR affects the convection heat transfer between crossflow and target surface, and it also affects the interaction between crossflow and jet. Synthetically, the best heat transfer appears at CR = 0.2. The Nusselt number decreases sharply when TR goes from 1.0 to 1.1, while the decline trend slows down when TR goes from 1.1 to 1.2.